UniProt:Q9HCU9 BRMS1

chain
  • chain:1-246
checksum 89FB59FB96ECD4DB
comment
  • FUNCTION Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.SUBUNIT Homohexamer (Potential). Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3.INTERACTION Predominantly nuclear.TISSUE SPECIFICITY Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.DOMAIN Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers.PTM Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.SIMILARITY Belongs to the BRMS1 family.
crossReference
databaseName UniProt
dbId 50970
description
  • recommendedName: Breast cancer metastasis-suppressor 1
displayName UniProt:Q9HCU9 BRMS1
geneName
  • BRMS1
identifier Q9HCU9
isSequenceChanged false
keyword
  • 3D-structure
  • Apoptosis
  • Coiled coil
  • Cytoplasm
  • Isopeptide bond
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
  • Tumor suppressor
  • Ubl conjugation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • BRMS1
otherIdentifier
  • 11732098_x_at
  • 11744290_a_at
  • 11744291_x_at
  • 11754127_a_at
  • 11754128_x_at
  • 11763771_at
  • 16740752
  • 215631_PM_s_at
  • 215631_s_at
  • 25855
  • 3378208
  • 3378209
  • 3378211
  • 3378212
  • 3378213
  • 3378214
  • 3378215
  • 3378216
  • 3378217
  • 3378218
  • 3378219
  • 3378220
  • 3378221
  • 3378222
  • 3378223
  • 3378224
  • 3378225
  • 3378226
  • 3378227
  • 37101_at
  • 37102_at
  • 7949603
  • A_23_P75500
  • A_33_P3367017
  • GE56225
  • GO:0000122
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0006355
  • GO:0006915
  • GO:0010468
  • GO:0030336
  • GO:0030512
  • GO:0032088
  • GO:0042826
  • GO:0042981
  • GO:0045892
  • GO:0051059
  • GO:0070822
  • GO:0090312
  • GO:1902455
  • GO:1902459
  • GO:2000210
  • HMNXSV003011442
  • Hs.306186.0.S1_3p_s_at
  • ILMN_1719165
  • ILMN_2398432
  • TC11001964.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BRMS1_HUMAN
  • Q6IAI2
sequenceLength 246
species [Species:48887] Homo sapiens
stId uniprot:Q9HCU9
url http://purl.uniprot.org/uniprot/Q9HCU9
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