Reactome | UniProt:Q9HCE9 ANO8

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UniProt:Q9HCE9 ANO8 Show undefined attributes

chain	initiator methionine:1 chain:2-1232
checksum	1802BC3544A9234C
comment	FUNCTION Does not exhibit calcium-activated chloride channel (CaCC) activity.SUBCELLULAR LOCATION Shows predominantly an intracellular localization with a weak expression in the cell membrane.ALTERNATIVE PRODUCTS Expressed in embryonic stem cells, fetal brain and neural tissues.MISCELLANEOUS The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.SIMILARITY Belongs to the anoctamin family.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12399854] RefSeq:NP_066010.1 [DatabaseIdentifier:12280987] Pharos - Targets:Q9HCE9 [DatabaseIdentifier:12238239] PRO:Q9HCE9 [DatabaseIdentifier:12120653] OpenTargets:ENSG00000074855 [DatabaseIdentifier:11836182] HPA:ENSG00000074855-ANO8 [DatabaseIdentifier:11830549] HMDB Protein:HMDBP07446 [DatabaseIdentifier:11783073] GeneCards:ANO8 [DatabaseIdentifier:11713115] ENSEMBL:ENST00000159087 [DatabaseIdentifier:11590416] ENSEMBL:ENSP00000159087 [DatabaseIdentifier:11486399] ENSEMBL:ENSG00000074855
databaseName	UniProt
dbId	251605
description	recommendedName: Anoctamin-8 alternativeName: Transmembrane protein 16H
displayName	UniProt:Q9HCE9 ANO8
geneName	ANO8 KIAA1623 TMEM16H
identifier	Q9HCE9
isSequenceChanged	false
keyword	Acetylation Alternative splicing Cell membrane Membrane Methylation Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	ANO8
otherIdentifier	11756319_a_at 1563549_PM_a_at 1563549_a_at 16870174 3854377 3854378 3854379 3854382 3854384 3854385 3854386 3854387 3854388 3854389 3854390 3854391 3854392 3854393 3854394 3854395 3854396 3854397 3854398 3854399 3854400 3854401 3854402 3854403 3854405 3854406 3854407 3854408 3854409 3854410 57719 8035278 A_32_P73452 GE85196 GO:0005229 GO:0005254 GO:0005788 GO:0005886 GO:0016020 GO:0034220 GO:0055085 GO:1902476 HMNXSV003024952 Hs2.421680.1.S1_3p_a_at ILMN_1709124 PH_hs_0019747 TC19001273.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2684888] ANO8 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8956909] p-ANO8 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8956742] ANO8 [endoplasmic reticulum lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12696307] UCSC:Q9HCE9 ANO8 [ReferenceDNASequence:12106439] OMIM:610216 ANO8 [ReferenceDNASequence:12065561] NCBI Gene:57719 ANO8 [ReferenceDNASequence:11981468] Monarch:57719 ANO8 [ReferenceDNASequence:11891427] KEGG:hsa:57719 ANO8 [ReferenceDNASequence:11814685] HGNC:29329 ANO8 [ReferenceDNASequence:11429797] dbSNP Gene:57719 ANO8 [ReferenceDNASequence:11406653] CTD Gene:57719 ANO8 [ReferenceDNASequence:11393799] COSMIC - genes:ANO8 ANO8 [ReferenceDNASequence:11351679] BioGPS Gene:57719 ANO8 [ReferenceDNASequence:ensembl:ENSG00000074855] ENSEMBL:ENSG00000074855 ANO8
referenceTranscript	[ReferenceRNASequence:12581565] RefSeq:NM_020959.3 ANO8
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ANO8_HUMAN A6NIJ0
sequenceLength	1232
species	[Species:48887] Homo sapiens
stId	uniprot:Q9HCE9
url	http://purl.uniprot.org/uniprot/Q9HCE9

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2684888] ANO8 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-8956909] p-ANO8 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-8956742] ANO8 [endoplasmic reticulum lumen]
(referenceSequence)	[ModifiedResidue:8957084] phosphorylated residue at unknown position