UniProt:Q9HC84 MUC5B

chain
  • signal peptide:1-25
  • chain:26-5762
checksum 1FEC7CDCD0ADA81C
comment
  • FUNCTION Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.SUBUNIT Homomultimer; disulfide-linked (PubMed:31570524). The N- and C-terminus mediate their assembly into higher order structures to form filaments (By similarity). The CTCK domains of two polypeptides associate in the endoplasmic reticulum to generate intermolecularly disulfide-bonded dimers (PubMed:31570524). These dimers progress to the Golgi apparatus, which is a more acidic environment than the endoplasmic reticulum (By similarity). Under acidic conditions, the N-termini form non-covalent intermolecular interactions that juxtapose assemblies from different CTCK-linked dimers to produce long, disulfide-linked polymers that remain highly compact until secretion (By similarity).SUBCELLULAR LOCATION Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas.INDUCTION Regulated by all-trans-retinoic acid (ATRA) in a cell-type specific manner.DOMAIN The CTCK domain mediates interchain disulfide bonds with another molecule of MUC5B.DOMAIN The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.PTM Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc(2)Hex(1)HexNac1-ol.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741).SEQUENCE CAUTION Truncated N-terminus.
crossReference
databaseName UniProt
dbId 59699
description
  • recommendedName: Mucin-5B shortName: MUC-5B alternativeName: Cervical mucin alternativeName: High molecular weight salivary mucin MG1 alternativeName: Mucin-5 subtype B, tracheobronchial alternativeName: Sublingual gland mucin
displayName UniProt:Q9HC84 MUC5B
geneName
  • MUC5B
  • MUC5
identifier Q9HC84
isSequenceChanged false
keyword
  • 3D-structure
  • Copper
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Metal-binding
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • MUC5B
otherIdentifier
  • 11744063_a_at
  • 11744064_at
  • 11748931_a_at
  • 16720601
  • 213432_PM_at
  • 213432_at
  • 222268_3p_x_at
  • 222268_PM_x_at
  • 222268_x_at
  • 3316713
  • 3316714
  • 3316715
  • 3316717
  • 3316718
  • 3316719
  • 3316720
  • 3316721
  • 3316722
  • 3316723
  • 3316724
  • 3316725
  • 3316726
  • 3316727
  • 3316728
  • 3316729
  • 3316730
  • 3316731
  • 3316733
  • 3316734
  • 3316735
  • 3316736
  • 3316737
  • 3316738
  • 3316741
  • 3316742
  • 3316743
  • 3316744
  • 3316745
  • 3316746
  • 3316747
  • 3316748
  • 3316749
  • 3316750
  • 3316751
  • 3316752
  • 3316753
  • 3316754
  • 3316755
  • 3316756
  • 3316757
  • 3316758
  • 3316759
  • 3316760
  • 3316761
  • 3316762
  • 3316763
  • 3316764
  • 3316765
  • 3316766
  • 3316767
  • 3316768
  • 3316769
  • 3316770
  • 3316771
  • 3316772
  • 3316773
  • 3316774
  • 3316775
  • 3316776
  • 3316777
  • 3316778
  • 3316779
  • 3316780
  • 3316781
  • 3316783
  • 3316784
  • 3316785
  • 3316786
  • 3316787
  • 3316788
  • 3316789
  • 3316790
  • 3316791
  • 3316792
  • 3316793
  • 3316794
  • 3316795
  • 3316796
  • 3316797
  • 3316798
  • 3316799
  • 3316800
  • 3316801
  • 3316802
  • 3316804
  • 3316805
  • 3316806
  • 3316807
  • 3316808
  • 41365_at
  • 60740_at
  • 694_at
  • 727897
  • 7937612
  • A_23_P305863
  • A_24_P102650
  • A_24_P324141
  • A_24_P916789
  • GE564339
  • GE60272
  • GO:0005198
  • GO:0005201
  • GO:0005515
  • GO:0005576
  • GO:0005615
  • GO:0005796
  • GO:0005886
  • GO:0030312
  • GO:0031012
  • GO:0046872
  • GO:0070062
  • HMNXSV003052173
  • Hs.102482.1.A1_3p_at
  • Hs.321110.0.S1_3p_at
  • Hs.321110.0.S1_3p_x_at
  • ILMN_1693983
  • PH_hs_0040975
  • TC11002495.hg
  • TC11002497.hg
  • TC11002498.hg
  • TC11002499.hg
  • TC11003510.hg
  • U78551_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MUC5B_HUMAN
  • O00447
  • O00573
  • O14985
  • O15494
  • O95291
  • O95451
  • Q14881
  • Q7M4S5
  • Q99552
  • Q9UE28
sequenceLength 5762
species [Species:48887] Homo sapiens
stId uniprot:Q9HC84
url http://purl.uniprot.org/uniprot/Q9HC84

Referrals

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(referenceSequence)
(interactor)
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