UniProt:Q9HB55 CYP3A43

chain
  • chain:1-503
checksum 2C585B9DC573F634
comment
  • FUNCTION Exhibits low testosterone 6-beta-hydroxylase activity.CATALYTIC ACTIVITY an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)COFACTOR Additional isoforms seem to exist.TISSUE SPECIFICITY Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.INDUCTION By rifampicin.POLYMORPHISM At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional.MISCELLANEOUS Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the cytochrome P450 family.ONLINE INFORMATION CYP3A43 alleles
created [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference
databaseName UniProt
dbId 414382
description
  • recommendedName: Cytochrome P450 3A43 ecNumber: 1.14.14.1
displayName UniProt:Q9HB55 CYP3A43
geneName
  • CYP3A43
identifier Q9HB55
isSequenceChanged false
keyword
  • Alternative splicing
  • Endoplasmic reticulum
  • Heme
  • Iron
  • Membrane
  • Metal-binding
  • Microsome
  • Monooxygenase
  • Oxidoreductase
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • CYP3A43
otherIdentifier
  • 11731990_a_at
  • 17049032
  • 207773_PM_x_at
  • 207773_x_at
  • 211440_PM_x_at
  • 211440_x_at
  • 211441_PM_x_at
  • 211441_x_at
  • 211442_PM_x_at
  • 211442_x_at
  • 3015050
  • 3015051
  • 3015052
  • 3015056
  • 3015057
  • 3015058
  • 3015059
  • 3015060
  • 3015061
  • 3015062
  • 3015063
  • 3015064
  • 3015065
  • 3015066
  • 3015067
  • 3015069
  • 3015070
  • 3015071
  • 3015072
  • 3015074
  • 3015076
  • 3015077
  • 3015078
  • 64816
  • 8134655
  • A_14_P138673
  • A_23_P215828
  • A_23_P71258
  • GE62605
  • GO:0002933
  • GO:0004497
  • GO:0005506
  • GO:0005783
  • GO:0005789
  • GO:0006629
  • GO:0008202
  • GO:0008210
  • GO:0008401
  • GO:0009822
  • GO:0016020
  • GO:0016491
  • GO:0016705
  • GO:0016712
  • GO:0019825
  • GO:0020037
  • GO:0042178
  • GO:0042573
  • GO:0046222
  • GO:0046872
  • GO:0050649
  • GO:0070989
  • GO:0101020
  • GO:1903604
  • HMNXSV003017213
  • ILMN_1673591
  • ILMN_2377288
  • PH_hs_0015727
  • TC07000601.hg
  • g11225241_3p_a_at
  • g11225241_3p_x_at
  • g11225243_3p_a_at
  • g11225243_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CP343_HUMAN
  • Q495Y1
  • Q75MK2
  • Q75MK3
  • Q9HB52
  • Q9HB53
  • Q9HB54
  • Q9HB57
sequenceLength 503
species [Species:48887] Homo sapiens
stId uniprot:Q9HB55
url http://purl.uniprot.org/uniprot/Q9HB55
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