Reactome | UniProt:Q9HAJ7 SAP30L

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UniProt:Q9HAJ7 SAP30L Show undefined attributes

chain	chain:1-183
checksum	EB19E448C6A1FA45
comment	FUNCTION Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676).FUNCTION Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3.FUNCTION Functions as a transcription repressor; its activity is marginally lower than that of isoform 1.SUBUNIT Interacts with components of the histone deacetylase complex SIN3A, HDAC1 and HDAC2 (PubMed:16820529). Binds histones and nucleosomes (PubMed:19015240). Interacts with FEZ1 (PubMed:16484223).INTERACTION Detected in brain and ovary, and at lower levels in heart, small intestine, lung, kidney, skeletal muscle, stomach and spleen (at protein level) (PubMed:18070604). Ubiquitous; expressed in all tissues tested with highest levels in testis (PubMed:14680513).INDUCTION Up-regulated by TGFB1.DOMAIN The zinc-finger domain mediates direct interaction with DNA and phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) (PubMed:26609676). In vitro oxydation causes reversible disulfide bond formation between Cys residues in the zinc-finger domain and reversible loss of zinc ion binding (PubMed:26609676).SIMILARITY Belongs to the SAP30 family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12479301] RefSeq:NP_001124535.1 [DatabaseIdentifier:12479302] RefSeq:NP_001124534.1 [DatabaseIdentifier:12479303] RefSeq:NP_078908.1 [DatabaseIdentifier:12292589] Pharos - Targets:Q9HAJ7 [DatabaseIdentifier:12275666] PRO:Q9HAJ7 [DatabaseIdentifier:12224696] PDB:2N1U [DatabaseIdentifier:12132418] OpenTargets:ENSG00000164576 [DatabaseIdentifier:11847735] HPA:ENSG00000164576-SAP30L [DatabaseIdentifier:11810704] GlyGen:Q9HAJ7 [DatabaseIdentifier:11794766] GeneCards:SAP30L [DatabaseIdentifier:11768339] ENSEMBL:ENST00000440364 [DatabaseIdentifier:11768337] ENSEMBL:ENST00000426761 [DatabaseIdentifier:11768338] ENSEMBL:ENST00000297109 [DatabaseIdentifier:11645640] ENSEMBL:ENSP00000390927 [DatabaseIdentifier:11645638] ENSEMBL:ENSP00000297109 [DatabaseIdentifier:11645639] ENSEMBL:ENSP00000416393 [DatabaseIdentifier:11524456] ENSEMBL:ENSG00000164576
databaseName	UniProt
dbId	248926
description	recommendedName: Histone deacetylase complex subunit SAP30L alternativeName: HCV non-structural protein 4A-transactivated protein 2 alternativeName: Sin3 corepressor complex subunit SAP30L alternativeName: Sin3-associated protein p30-like
displayName	UniProt:Q9HAJ7 SAP30L
geneName	SAP30L NS4ATP2
identifier	Q9HAJ7
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Disulfide bond DNA-binding Isopeptide bond Lipid-binding Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SAP30L
otherIdentifier	11720376_a_at 11720377_s_at 11720378_a_at 11737711_a_at 16991374 219129_PM_s_at 219129_s_at 225509_PM_at 225509_at 232135_PM_at 232135_at 2836664 2836666 2836667 2836668 2836669 2836670 2836671 2836676 2836677 2836678 2836679 2836680 2836681 2836682 2836683 2836685 2836686 2836687 2836688 2836690 44153_at 56307_at 71085_at 79685 8109428 A_14_P100133 A_23_P368101 A_24_P191971 GE57027 GE80569 GO:0000118 GO:0000122 GO:0001650 GO:0003677 GO:0003712 GO:0005515 GO:0005634 GO:0005654 GO:0005730 GO:0006355 GO:0008270 GO:0008289 GO:0010314 GO:0030336 GO:0030512 GO:0031491 GO:0032266 GO:0042393 GO:0044378 GO:0046872 GO:0070273 GO:0070822 GO:1902455 GO:1902459 HMNXSV003003002 Hs.20552.0.S1_3p_at Hs.22350.0.S1_3p_at Hs.22350.0.S1_3p_x_at ILMN_1757781 ILMN_1843932 PH_hs_0022342 PH_hs_0039869 TC05000852.hg TC05000853.hg TC05002703.hg g13375861_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-351698] SAP30L [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12717944] UCSC:Q9HAJ7 SAP30L [ReferenceDNASequence:12116777] OMIM:610398 SAP30L [ReferenceDNASequence:12102172] NCBI Gene:79685 SAP30L [ReferenceDNASequence:12018079] Monarch:79685 SAP30L [ReferenceDNASequence:11924659] KEGG:hsa:79685 SAP30L [ReferenceDNASequence:11826462] HGNC:25663 SAP30L [ReferenceDNASequence:11433301] dbSNP Gene:79685 SAP30L [ReferenceDNASequence:11423592] CTD Gene:79685 SAP30L [ReferenceDNASequence:11396776] COSMIC - genes:SAP30L SAP30L [ReferenceDNASequence:11388290] BioGPS Gene:79685 SAP30L [ReferenceDNASequence:ensembl:ENSG00000164576] ENSEMBL:ENSG00000164576 SAP30L
referenceTranscript	[ReferenceRNASequence:12660806] RefSeq:NM_024632.6 SAP30L [ReferenceRNASequence:12660804] RefSeq:NM_001131063.2 SAP30L [ReferenceRNASequence:12660805] RefSeq:NM_001131062.2 SAP30L
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SP30L_HUMAN E9PAU7 E9PAY2
sequenceLength	183
species	[Species:48887] Homo sapiens
stId	uniprot:Q9HAJ7
url	http://purl.uniprot.org/uniprot/Q9HAJ7

Referrals

(interactor)	[UndirectedInteraction:11274987] UniProt:Q13547 <-> UniProt:Q9HAJ7 (IntAct) [UndirectedInteraction:11240957] UniProt:Q9H160 <-> UniProt:Q9HAJ7 (IntAct) [UndirectedInteraction:11232537] UniProt:Q09028 <-> UniProt:Q9HAJ7 (IntAct) [UndirectedInteraction:11190269] UniProt:Q92769 <-> UniProt:Q9HAJ7 (IntAct) [UndirectedInteraction:11141271] UniProt:Q16576 <-> UniProt:Q9HAJ7 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-351698] SAP30L [nucleoplasm]