UniProt:Q9H8H3 TMT1A

chain
  • signal peptide:1-29
  • chain:30-244
checksum 6967783BAB2348BE
comment
  • FUNCTION Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed:37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed:34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed:34226523, PubMed:34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed:19773358).FUNCTION (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation.CATALYTIC ACTIVITY a thiol + S-adenosyl-L-methionine = a methyl thioether + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)ACTIVITY REGULATION Inhibited by 2,3-dichloro-alpha-methylbenzylamine (DCMB).BIOPHYSICOCHEMICAL PROPERTIES (Microbial infection) Interacts with HCV non-structural protein 4B/NS4B (via C-terminal region); this interaction may promote the recruitment of NS4B in the proximity of lipid droplet.SUBUNIT Self-associates (PubMed:18477614). Interacts with SNRNP200; this interaction may promote the odontogenic differentiation (PubMed:34790668).INTERACTION Inserted in the ER membrane and migrates from the inserted site to lipid droplet.TISSUE SPECIFICITY Expressed in the liver.INDUCTION Silenced by miR-6807-5p.PTM Methylated at lysine residues most likely by EZH2.MISCELLANEOUS Selectively methylates drugs containing thiol-moieties such as 7alpha-thiospironolactone and mertansine.SIMILARITY Belongs to the methyltransferase superfamily.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 237172
description
  • recommendedName: Thiol S-methyltransferase TMT1A ecNumber evidence="7"2.1.1.9 alternativeName: fullName evidence="10"Methyltransferase-like protein 7A alternativeName: N6-adenosine-methyltransferase TMT1A ecNumber evidence="6"2.1.1.348 alternativeName: fullName evidence="8"Protein AAM-B alternativeName: fullName evidence="12"Thiol methyltransferase 1A
displayName UniProt:Q9H8H3 TMT1A
geneName
  • TMT1A
  • METTL7A
  • PRO0066
  • UNQ1902/PRO4348
identifier Q9H8H3
isSequenceChanged false
keyword
  • Cytoplasm
  • Endoplasmic reticulum
  • Host-virus interaction
  • Lipid droplet
  • Membrane
  • Methylation
  • Methyltransferase
  • Microsome
  • Proteomics identification
  • Reference proteome
  • Signal
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • TMT1A
otherIdentifier
  • 11719375_x_at
  • 11745465_x_at
  • 11757815_s_at
  • 16751190
  • 207761_PM_s_at
  • 207761_s_at
  • 209703_3p_x_at
  • 209703_PM_x_at
  • 209703_x_at
  • 211424_PM_x_at
  • 25840
  • 3414740
  • 3414741
  • 3414742
  • 3414745
  • 3414746
  • 3414747
  • 3414748
  • 3414749
  • 3414750
  • 3414751
  • 3414752
  • 3414753
  • 3414755
  • 3414756
  • 3414757
  • 3455178
  • 38717_at
  • 7955441
  • A_23_P415021
  • A_24_P941773
  • GE56263
  • GE87721
  • GO:0001649
  • GO:0001734
  • GO:0003824
  • GO:0005515
  • GO:0005576
  • GO:0005737
  • GO:0005783
  • GO:0005811
  • GO:0005829
  • GO:0008168
  • GO:0008173
  • GO:0008757
  • GO:0016020
  • GO:0016740
  • GO:0018708
  • GO:0030154
  • GO:0032259
  • GO:0042476
  • GO:0043226
  • GO:0140098
  • GO:0180035
  • GO:1904724
  • HMNXSV003025099
  • ILMN_1656285
  • PH_hs_0014995
  • TC12000399.hg
  • g13325369_3p_x_at
  • g13378140_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TMT1A_HUMAN
  • Q9H7R3
  • Q9UHZ7
  • Q9Y422
sequenceLength 244
species [Species:48887] Homo sapiens
stId uniprot:Q9H8H3
url http://purl.uniprot.org/uniprot/Q9H8H3
Cite Us!