UniProt:Q9H6S0 YTHDC2

chain
  • chain:1-1430
checksum A0C3B45771A3DE16
comment
  • FUNCTION 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT Interacts with MEIOC; binds transcripts that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally (By similarity). Interacts (via ANK repeats) with XRN1 (PubMed:29033321, PubMed:29970596). Interacts with ZCCHC4 (PubMed:31799605). Associates with the small ribosomal subunit (PubMed:29970596). Interacts with RBM46 (By similarity).INTERACTION Expressed in testis (PubMed:29087293). Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (PubMed:29087293).DOMAIN The YTH domain mediates RNA-binding. It recognizes and binds N6-methyladenosine (m6A)-containing RNAs.SIMILARITY Belongs to the DEAD box helicase family. DEAH subfamily.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 257083
description
  • recommendedName: fullName evidence="16"3'-5' RNA helicase YTHDC2 ecNumber evidence="11"3.6.4.13 alternativeName: fullName evidence="15"YTH domain-containing protein 2 shortName evidence="15"hYTHDC2
displayName UniProt:Q9H6S0 YTHDC2
geneName
  • YTHDC2
identifier Q9H6S0
isSequenceChanged false
keyword
  • 3D-structure
  • ANK repeat
  • ATP-binding
  • Cytoplasm
  • Differentiation
  • Helicase
  • Hydrolase
  • Meiosis
  • Nucleotide-binding
  • Oogenesis
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • RNA-binding
  • Spermatogenesis
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • YTHDC2
otherIdentifier
  • 11722148_a_at
  • 11722149_a_at
  • 1568680_PM_s_at
  • 1568680_s_at
  • 16988087
  • 205835_PM_s_at
  • 205835_s_at
  • 205836_PM_s_at
  • 205836_s_at
  • 213077_PM_at
  • 213077_at
  • 2824490
  • 2824491
  • 2824492
  • 2824493
  • 2824494
  • 2824495
  • 2824496
  • 2824497
  • 2824499
  • 2824501
  • 2824503
  • 2824504
  • 2824505
  • 2824506
  • 2824507
  • 2824510
  • 2824511
  • 2824512
  • 2824513
  • 2824515
  • 2824516
  • 2824517
  • 2824518
  • 2824520
  • 2824522
  • 2824523
  • 2824524
  • 2824525
  • 2824526
  • 2824527
  • 2824528
  • 2824531
  • 2824532
  • 2824533
  • 2824534
  • 2824535
  • 2824537
  • 2824538
  • 2824539
  • 2824540
  • 2824541
  • 2824542
  • 2824543
  • 2824544
  • 2824545
  • 2824546
  • 2824547
  • 2824548
  • 2824549
  • 2824550
  • 2824551
  • 41398_at
  • 64848
  • 78857_at
  • 8107375
  • A_14_P131432
  • A_23_P41732
  • A_24_P178106
  • A_33_P3420747
  • GE55651
  • GO:0000166
  • GO:0003676
  • GO:0003723
  • GO:0003724
  • GO:0003824
  • GO:0004386
  • GO:0005515
  • GO:0005524
  • GO:0005737
  • GO:0005783
  • GO:0007283
  • GO:0007286
  • GO:0008186
  • GO:0016787
  • GO:0016887
  • GO:0022414
  • GO:0030154
  • GO:0034458
  • GO:0034612
  • GO:0035770
  • GO:0043226
  • GO:0044829
  • GO:0048471
  • GO:0048477
  • GO:0048599
  • GO:0048856
  • GO:0051321
  • GO:0051729
  • GO:0060090
  • GO:0070063
  • GO:0070555
  • GO:0140098
  • GO:0140657
  • GO:1990247
  • HMNXSV003038932
  • HMNXSV003040089
  • Hs.104916.0.S1_3p_a_at
  • Hs.104916.1.S1_3p_at
  • Hs2.382774.1.S1_3p_s_at
  • ILMN_1725760
  • TC05000538.hg
  • g12383069_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • YTDC2_HUMAN
  • B2RP66
sequenceLength 1430
species [Species:48887] Homo sapiens
stId uniprot:Q9H6S0
url http://purl.uniprot.org/uniprot/Q9H6S0

Referrals

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