UniProt:Q9H3Z4 DNAJC5

chain
  • chain:1-198
checksum A3F89270EBAD8A25
comment
  • FUNCTION Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).SUBUNIT Oligomers (PubMed:27452402). Homodimer (By similarity). Interacts with the chaperone complex consisting of HSC70 and SGTA (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895). Interacts with SYT1, SYT5 and SYT7, and with SYT9, forming a complex with SNAP25 (By similarity).INTERACTION The association with membranes is regulated by palmitoylation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).ALTERNATIVE PRODUCTS Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.PTM Ser-10 phosphorylation induces an order-to-disorder transition triggering the interaction with Lys-58 (PubMed:27452402). This conformational switch modulates DNAJC5's cellular functions by reducing binding to syntaxin and synaptogamin without altering HSC70 interactions (PubMed:27452402).PTM Palmitoylated. Could be palmitoylated by DHHC3, DHHC7, DHHC15 and DHHC17. Palmitoylation occurs probably in the cysteine-rich domain and regulates DNAJC5 membrane attachment.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Upon phosphorylation, Ser-10 interacts with Lys-58, a highly conserved residue in DnaJ proteins that is also a ubiquitination site in DNAJC5.
crossReference
databaseName UniProt
dbId 53700
description
  • recommendedName: fullName evidence="17"DnaJ homolog subfamily C member 5 alternativeName: fullName evidence="17"Ceroid-lipofuscinosis neuronal protein 4 alternativeName: fullName evidence="16"Cysteine string protein shortName evidence="16"CSP
displayName UniProt:Q9H3Z4 DNAJC5
geneName
  • DNAJC5
  • CLN4
identifier Q9H3Z4
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cell membrane
  • Chaperone
  • Cytoplasm
  • Cytoplasmic vesicle
  • Disease variant
  • Lipoprotein
  • Membrane
  • Neurodegeneration
  • Neuronal ceroid lipofuscinosis
  • Palmitate
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • DNAJC5
otherIdentifier
  • 11724521_a_at
  • 11724522_a_at
  • 11758906_at
  • 11764090_s_at
  • 16916146
  • 16916156
  • 16916158
  • 16916161
  • 224611_PM_s_at
  • 224611_s_at
  • 224612_PM_s_at
  • 224612_s_at
  • 224613_PM_s_at
  • 224613_s_at
  • 244601_PM_at
  • 244601_at
  • 35728_at
  • 3893794
  • 3893797
  • 3893799
  • 3893800
  • 3893801
  • 3893802
  • 3893803
  • 3893804
  • 3893805
  • 3893806
  • 3893807
  • 3893808
  • 3893809
  • 3893810
  • 3893811
  • 3893812
  • 3893813
  • 45317_at
  • 57109_at
  • 63699_at
  • 80331
  • 8064208
  • 82410_at
  • A_14_P134736
  • A_24_P205316
  • A_33_P3363153
  • A_33_P3419733
  • GE61045
  • GE86838
  • GO:0005515
  • GO:0005737
  • GO:0005739
  • GO:0005765
  • GO:0005829
  • GO:0005886
  • GO:0006457
  • GO:0006887
  • GO:0008021
  • GO:0016020
  • GO:0016079
  • GO:0016192
  • GO:0030672
  • GO:0031410
  • GO:0031594
  • GO:0035577
  • GO:0035579
  • GO:0042470
  • GO:0042584
  • GO:0043008
  • GO:0043524
  • GO:0045055
  • GO:0051402
  • GO:0061202
  • GO:0098693
  • GO:0098793
  • HMNXSV003002732
  • HMNXSV003038941
  • Hs.165563.0.S1_3p_a_at
  • Hs.165563.0.S2_3p_a_at
  • Hs.165563.0.S3_3p_a_at
  • ILMN_1789642
  • PH_hs_0035632
  • TC20000528.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DNJC5_HUMAN
  • A8K0M0
  • B3KY68
  • E1P5G8
  • Q9H3Z5
  • Q9H7H2
sequenceLength 198
species [Species:48887] Homo sapiens
stId uniprot:Q9H3Z4
url http://purl.uniprot.org/uniprot/Q9H3Z4
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