UniProt:Q9H2P0 ADNP

chain
  • chain:1-1102
checksum 4132E3EF814AF43B
comment
  • FUNCTION May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity).SUBUNIT Interacts (via N-terminal region) with beta-catenin/CTNNB1 (via the central armadillo domains); interaction is direct and stabilizes CTNNB1 by modulating its phosphorylation by glycogen synthase kinase-3 beta GSK3B.INTERACTION Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS When isolated from the sequence, neuroprotective peptide (NAP) provides neuroprotection against the amyloid-beta peptide.
crossReference
databaseName UniProt
dbId 49732
description
  • recommendedName: Activity-dependent neuroprotector homeobox protein alternativeName: Activity-dependent neuroprotective protein
displayName UniProt:Q9H2P0 ADNP
geneName
  • ADNP
  • ADNP1
  • KIAA0784
identifier Q9H2P0
isSequenceChanged false
keyword
  • Acetylation
  • Autism spectrum disorder
  • Chromosome
  • DNA-binding
  • Homeobox
  • Intellectual disability
  • Isopeptide bond
  • Metal-binding
  • Methylation
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
  • Ubl conjugation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • ADNP
otherIdentifier
  • 11715983_a_at
  • 11715984_s_at
  • 11740587_a_at
  • 16920277
  • 201773_PM_at
  • 201773_at
  • 226426_PM_at
  • 226426_at
  • 23394
  • 34394_at
  • 3909355
  • 3909356
  • 3909357
  • 3909358
  • 3909359
  • 3909360
  • 3909364
  • 3909366
  • 3909367
  • 3909368
  • 3909369
  • 3909370
  • 3909371
  • 3909373
  • 3909389
  • 3909393
  • 3909394
  • 44667_at
  • 8067011
  • A_23_P254179
  • A_24_P134319
  • GE53487
  • GO:0000785
  • GO:0000977
  • GO:0000981
  • GO:0003677
  • GO:0003682
  • GO:0005507
  • GO:0005515
  • GO:0005615
  • GO:0005634
  • GO:0005694
  • GO:0006355
  • GO:0006357
  • GO:0007614
  • GO:0008013
  • GO:0008092
  • GO:0008270
  • GO:0009743
  • GO:0010468
  • GO:0010629
  • GO:0010976
  • GO:0019934
  • GO:0022414
  • GO:0030182
  • GO:0030424
  • GO:0030425
  • GO:0033484
  • GO:0042277
  • GO:0043025
  • GO:0043524
  • GO:0044849
  • GO:0045773
  • GO:0046872
  • GO:0048487
  • GO:0050805
  • GO:0050877
  • GO:0051402
  • GO:0051965
  • GO:0090263
  • GO:0090575
  • HMNXSV003016457
  • Hs.31539.0.A1_3p_at
  • ILMN_1657993
  • ILMN_1666019
  • PH_hs_0026205
  • TC20000939.hg
  • g12229216_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ADNP_HUMAN
  • E1P5Y2
  • O94881
  • Q5BKU2
  • Q9UG34
sequenceLength 1102
species [Species:48887] Homo sapiens
stId uniprot:Q9H2P0
url http://purl.uniprot.org/uniprot/Q9H2P0
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