UniProt:Q9H2H9 SLC38A1

chain
  • chain:1-487
checksum 5CBC96880D7BDE03
comment
  • FUNCTION Symporter that cotransports short-chain neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062).CATALYTIC ACTIVITY L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out)CATALYTIC ACTIVITY L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out)CATALYTIC ACTIVITY L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out)CATALYTIC ACTIVITY L-histidine(in) + Na(+)(in) = L-histidine(out) + Na(+)(out)CATALYTIC ACTIVITY L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)CATALYTIC ACTIVITY L-cysteine(in) + Na(+)(in) = L-cysteine(out) + Na(+)(out)CATALYTIC ACTIVITY L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out)CATALYTIC ACTIVITY glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out)CATALYTIC ACTIVITY L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out)CATALYTIC ACTIVITY L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)ACTIVITY REGULATION Inhibited by alpha-(methylamino)isobutyric acid (MeAIB). Inhibited by lithium, potassium, choline ions, N-methylglucamine. The pH dependence has an allosteric effect on the transport.BIOPHYSICOCHEMICAL PROPERTIES Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain.TISSUE SPECIFICITY Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis (PubMed:10891391, PubMed:12388062, PubMed:15054072, PubMed:16148032). Highly expressed in cytotrophoblast cells from term placenta (PubMed:20599747).INDUCTION Down-regulated by bacterial lipopolysaccharides (LPS) in glial cells (PubMed:12388062). Down-regulated upon hypoxia (PubMed:16583402).PTM N-glycosylation plays an important role in the L-glutamine transport.SIMILARITY Belongs to the amino acid/polyamine transporter 2 family.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:212600] Mahajan, SS, 2008-02-12 19:05:29
crossReference
databaseName UniProt
dbId 212603
description
  • recommendedName: fullName evidence="13"Sodium-coupled neutral amino acid symporter 1 alternativeName: Amino acid transporter A1 alternativeName: N-system amino acid transporter 2 alternativeName: Solute carrier family 38 member 1 alternativeName: System A amino acid transporter 1 alternativeName: System N amino acid transporter 1
displayName UniProt:Q9H2H9 SLC38A1
geneName
  • SLC38A1
  • ATA1
  • NAT2
  • SAT1
  • SNAT1
identifier Q9H2H9
isSequenceChanged false
keyword
  • Amino-acid transport
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Ion transport
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Sodium
  • Sodium transport
  • Symport
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • SLC38A1
otherIdentifier
  • 11717100_a_at
  • 11717101_a_at
  • 11717102_a_at
  • 11717103_s_at
  • 11754821_s_at
  • 16763512
  • 218237_PM_s_at
  • 218237_s_at
  • 224579_PM_at
  • 224579_at
  • 224580_PM_at
  • 224580_at
  • 242367_PM_at
  • 242367_at
  • 3452232
  • 3452233
  • 3452234
  • 3452235
  • 3452236
  • 3452237
  • 3452238
  • 3452239
  • 3452245
  • 3452246
  • 3452247
  • 3452248
  • 3452249
  • 3452250
  • 3452251
  • 3452252
  • 3452253
  • 3452256
  • 3452261
  • 3452262
  • 3452263
  • 3452264
  • 3452266
  • 3452267
  • 3452268
  • 3452269
  • 3452270
  • 3452272
  • 3452279
  • 3452280
  • 3452281
  • 3452287
  • 3452288
  • 3452289
  • 3452290
  • 3452291
  • 3452294
  • 3452296
  • 3452297
  • 3452298
  • 3452299
  • 3452300
  • 3452301
  • 3452302
  • 3452303
  • 3452304
  • 3452305
  • 3452306
  • 3452307
  • 3452308
  • 3452309
  • 3452310
  • 45262_at
  • 46977_at
  • 61808_at
  • 65936_at
  • 78166_at
  • 7962516
  • 81539
  • A_23_P363399
  • A_24_P261734
  • A_33_P3288871
  • GE62003
  • GE86336
  • GE880769
  • GO:0001504
  • GO:0003013
  • GO:0003333
  • GO:0005283
  • GO:0005295
  • GO:0005298
  • GO:0005515
  • GO:0005886
  • GO:0006520
  • GO:0006811
  • GO:0006814
  • GO:0006865
  • GO:0006868
  • GO:0007565
  • GO:0009449
  • GO:0015171
  • GO:0015175
  • GO:0015179
  • GO:0015186
  • GO:0015293
  • GO:0015375
  • GO:0015655
  • GO:0015804
  • GO:0015816
  • GO:0016020
  • GO:0016323
  • GO:0022414
  • GO:0030424
  • GO:0032228
  • GO:0032328
  • GO:0035725
  • GO:0043025
  • GO:0043090
  • GO:0048167
  • GO:0055085
  • GO:0070062
  • GO:0098591
  • GO:0150104
  • GO:1902475
  • GO:1903803
  • HMNXSV003000506
  • HMNXSV003028475
  • HMNXSV003047745
  • Hs.132246.0.A1_3p_at
  • Hs.193063.0.S1_3p_at
  • Hs.193063.0.S2_3p_at
  • ILMN_1769911
  • ILMN_2266948
  • PH_hs_0022481
  • PH_hs_0037464
  • TC12001426.hg
  • TC12002850.hg
  • g13492978_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • S38A1_HUMAN
  • Q8NC61
  • Q8NCF8
  • Q96JX2
  • Q9H2Q2
sequenceLength 487
species [Species:48887] Homo sapiens
stId uniprot:Q9H2H9
url http://purl.uniprot.org/uniprot/Q9H2H9

Referrals

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