UniProt:Q9H0T7 RAB17

chain
  • chain:1-212
checksum 40E8CE5F445E5CF2
comment
  • FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB17 is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration (PubMed:22328529).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs).INTERACTION May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine.ALTERNATIVE PRODUCTS Expressed in melanocytes (at protein level).INDUCTION Up-regulated by forskolin probably through the transcription factor MITF.DOMAIN Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.SIMILARITY Belongs to the small GTPase superfamily. Rab family.
crossReference
databaseName UniProt
dbId 62742
description
  • recommendedName: Ras-related protein Rab-17 ecNumber evidence="2"3.6.5.2
displayName UniProt:Q9H0T7 RAB17
geneName
  • RAB17
identifier Q9H0T7
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell projection
  • Endosome
  • GTP-binding
  • Hydrolase
  • Lipoprotein
  • Magnesium
  • Membrane
  • Metal-binding
  • Nucleotide-binding
  • Phosphoprotein
  • Prenylation
  • Protein transport
  • Proteomics identification
  • Reference proteome
  • Transport
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • RAB17
otherIdentifier
  • 11731817_s_at
  • 16909891
  • 218931_PM_at
  • 218931_at
  • 2605482
  • 2605483
  • 2605484
  • 2605485
  • 2605486
  • 2605487
  • 2605488
  • 2605489
  • 2605490
  • 2605491
  • 2605492
  • 2605493
  • 2605494
  • 2605495
  • 2605498
  • 2605499
  • 2605501
  • 2605502
  • 2605508
  • 52119_at
  • 64284
  • 8059955
  • A_23_P5778
  • A_33_P3232011
  • GE62376
  • GO:0000166
  • GO:0002415
  • GO:0003924
  • GO:0005515
  • GO:0005525
  • GO:0005768
  • GO:0005769
  • GO:0005886
  • GO:0006886
  • GO:0007018
  • GO:0012505
  • GO:0015031
  • GO:0016020
  • GO:0016323
  • GO:0016324
  • GO:0016787
  • GO:0019003
  • GO:0030139
  • GO:0030425
  • GO:0031410
  • GO:0032401
  • GO:0032402
  • GO:0032456
  • GO:0032839
  • GO:0042470
  • GO:0042995
  • GO:0043025
  • GO:0044782
  • GO:0045056
  • GO:0046847
  • GO:0046872
  • GO:0050773
  • GO:0051489
  • GO:0051963
  • GO:0055037
  • GO:0055038
  • GO:0060271
  • GO:0070062
  • GO:0098794
  • GO:0098937
  • GO:0098978
  • GO:0120031
  • HMNXSV003026637
  • ILMN_2052373
  • PH_hs_0003215
  • TC02002908.hg
  • TC02004874.hg
  • g11967980_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RAB17_HUMAN
  • Q53QV6
  • Q6IA73
  • Q6PJZ0
  • Q9BVU1
  • Q9H9U9
sequenceLength 212
species [Species:48887] Homo sapiens
stId uniprot:Q9H0T7
url http://purl.uniprot.org/uniprot/Q9H0T7
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