UniProt:Q9H0R5 GBP3

chain
  • chain:1-595
checksum 410A9BED9ABD2DDF
comment
  • FUNCTION Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:22106366). Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Exhibits antiviral activity against influenza virus (PubMed:22106366).FUNCTION Shows the most prominent antiviral activity in epithelial cells.CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)SUBUNIT Heterodimer with other family members, including GBP1, GBP2 and GBP5 (PubMed:21151871). Dimerization regulates subcellular location.INTERACTION Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus.ALTERNATIVE PRODUCTS Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Unlikely isoform. Aberrant splice sites.
created [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
crossReference
databaseName UniProt
dbId 394351
description
  • recommendedName: Guanylate-binding protein 3 ecNumber evidence="2"3.6.5.- alternativeName: GTP-binding protein 3 shortName: GBP-3 alternativeName: Guanine nucleotide-binding protein 3
displayName UniProt:Q9H0R5 GBP3
geneName
  • GBP3
identifier Q9H0R5
isSequenceChanged false
keyword
  • Alternative splicing
  • Antiviral defense
  • Coiled coil
  • Cytoplasm
  • Golgi apparatus
  • GTP-binding
  • Hydrolase
  • Immunity
  • Innate immunity
  • Membrane
  • Nucleotide-binding
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • GBP3
otherIdentifier
  • 11741911_a_at
  • 16689312
  • 16689330
  • 223434_PM_at
  • 223434_at
  • 2345791
  • 2345796
  • 2345852
  • 2345857
  • 2421846
  • 2421847
  • 2421848
  • 2421849
  • 2421850
  • 2421851
  • 2421854
  • 2421856
  • 2421857
  • 2421858
  • 2421859
  • 2421860
  • 2421861
  • 2421862
  • 2421863
  • 2421864
  • 2421865
  • 2421867
  • 2421868
  • 2421869
  • 2421870
  • 2421871
  • 2421873
  • 2421874
  • 2421895
  • 2421897
  • 2421910
  • 2421941
  • 2635
  • 47533_at
  • 7917503
  • 7917514
  • A_23_P51487
  • A_24_P370702
  • GE88470
  • GO:0000139
  • GO:0000166
  • GO:0002376
  • GO:0003924
  • GO:0005515
  • GO:0005525
  • GO:0005737
  • GO:0005794
  • GO:0005829
  • GO:0016020
  • GO:0016787
  • GO:0031410
  • GO:0042742
  • GO:0042802
  • GO:0042803
  • GO:0045087
  • GO:0048471
  • GO:0051607
  • GO:0051715
  • GO:0071222
  • GO:0071346
  • GO:0071347
  • GO:0071356
  • GO:0098542
  • GO:0140639
  • HMNXSV003014026
  • HMNXSV003027931
  • ILMN_1725314
  • PH_hs_0005115
  • TC01002845.hg
  • TC01002846.hg
  • g12052883_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GBP3_HUMAN
  • A2A317
  • A6NF86
  • B2RTW0
  • F8UW81
  • Q05D54
  • Q5T8L8
  • Q5T8L9
  • Q6P3V3
  • Q9NV33
sequenceLength 595
species [Species:48887] Homo sapiens
stId uniprot:Q9H0R5
url http://purl.uniprot.org/uniprot/Q9H0R5
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