UniProt:Q9GZV9 FGF23

chain
  • signal peptide:1-24
  • chain:25-251
  • chain:25-179
  • chain:180-251
checksum 6093BD0CC50C2489
comment
  • FUNCTION Regulator of phosphate homeostasis (PubMed:11062477). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (PubMed:11409890). Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (PubMed:15040831). Negatively regulates osteoblast differentiation and matrix mineralization (PubMed:18282132).SUBUNIT Interacts with FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:16597617). Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).INTERACTION Secretion is dependent on O-glycosylation.TISSUE SPECIFICITY Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts).PTM Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases.PTM O-glycosylated at Thr-171 and Thr-178 by GALNT3 and glycosylation of Thr-178 requires previous glycosylation at Thr171. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23.PTM Phosphorylation at Ser-180 mediated by FAM20C slows down glycosylation at Thr-178 notably.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the heparin-binding growth factors family.
crossReference
databaseName UniProt
dbId 54808
description
  • recommendedName: Fibroblast growth factor 23 shortName: FGF-23 alternativeName: Phosphatonin alternativeName: Tumor-derived hypophosphatemia-inducing factor component recommendedName: Fibroblast growth factor 23 N-terminal peptide /component component recommendedName: Fibroblast growth factor 23 C-terminal peptide /component
displayName UniProt:Q9GZV9 FGF23
geneName
  • FGF23
  • HYPF
  • UNQ3027/PRO9828
identifier Q9GZV9
isSequenceChanged false
keyword
  • 3D-structure
  • Differentiation
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Growth factor
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Secreted
  • Signal
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • FGF23
otherIdentifier
  • 11738379_at
  • 11738380_at
  • 11738381_at
  • 16760148
  • 221166_PM_at
  • 221166_at
  • 3441169
  • 3441170
  • 3441171
  • 3441172
  • 3441173
  • 3441174
  • 3441175
  • 7960397
  • 8074
  • A_23_P117095
  • GE82551
  • GO:0000165
  • GO:0005104
  • GO:0005105
  • GO:0005515
  • GO:0005576
  • GO:0005615
  • GO:0005737
  • GO:0005788
  • GO:0005796
  • GO:0006355
  • GO:0006629
  • GO:0006766
  • GO:0008083
  • GO:0008284
  • GO:0008543
  • GO:0010966
  • GO:0010980
  • GO:0022008
  • GO:0030154
  • GO:0030334
  • GO:0030500
  • GO:0030502
  • GO:0030643
  • GO:0032026
  • GO:0042359
  • GO:0042369
  • GO:0043410
  • GO:0044320
  • GO:0045668
  • GO:0045893
  • GO:0046888
  • GO:0048018
  • GO:0055062
  • GO:0055074
  • GO:0070371
  • GO:0070374
  • GO:0071305
  • GO:0071354
  • GO:0071374
  • GO:0090080
  • GO:0098772
  • GO:1904383
  • HMNXSV003016648
  • ILMN_1696488
  • ILMN_1869676
  • ILMN_2071316
  • PH_hs_0014821
  • TC12001120.hg
  • g10190673_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • FGF23_HUMAN
  • Q4V758
sequenceLength 251
species [Species:48887] Homo sapiens
stId uniprot:Q9GZV9
url http://purl.uniprot.org/uniprot/Q9GZV9
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