Reactome | UniProt:Q9ERZ3 Chrm3

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UniProt:Q9ERZ3 Chrm3 Show undefined attributes

chain	chain:1-589
checksum	AB782149EBEE7804
comment	FUNCTION The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.SUBUNIT Homodimer; the dimers can form tetramers (By similarity). Interacts with NALCN (PubMed:19575010). Interacts with TMEM147 (By similarity).SUBCELLULAR LOCATION Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane.TISSUE SPECIFICITY Expressed in cerebral cortex, submandibular gland, hypothalamus, pancreas, liver, and ileum.SIMILARITY Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.
crossReference	[DatabaseIdentifier:12818837] ZINC - World Drugs:ACM3_MOUSE [DatabaseIdentifier:12815890] ZINC target:Q9ERZ3 [DatabaseIdentifier:12812518] ZINC - Substances:ACM3_MOUSE [DatabaseIdentifier:12810849] ZINC - Predictions - Purchasable:ACM3_MOUSE [DatabaseIdentifier:12807241] ZINC - Investigational:ACM3_MOUSE [DatabaseIdentifier:12806150] ZINC - FDA approved:ACM3_MOUSE [DatabaseIdentifier:12389693] RefSeq:NP_150372.1 [DatabaseIdentifier:12389694] RefSeq:NP_001415298.1 [DatabaseIdentifier:12389695] RefSeq:NP_001415299.1 [DatabaseIdentifier:12275506] PRO:Q9ERZ3 [DatabaseIdentifier:11934706] MGI:88398 [DatabaseIdentifier:11810598] GlyGen:Q9ERZ3 [DatabaseIdentifier:11706480] ENSEMBL:ENSMUST00000187510 [DatabaseIdentifier:11706481] ENSEMBL:ENSMUST00000063093 [DatabaseIdentifier:11583781] ENSEMBL:ENSMUSP00000140131 [DatabaseIdentifier:11583782] ENSEMBL:ENSMUSP00000055579 [DatabaseIdentifier:11482287] ENSEMBL:ENSMUSG00000046159
databaseName	UniProt
dbId	84510
description	recommendedName: Muscarinic acetylcholine receptor M3 alternativeName: Mm3 mAChR
displayName	UniProt:Q9ERZ3 Chrm3
geneName	Chrm3 Chrm-3
identifier	Q9ERZ3
isSequenceChanged	false
keyword	Cell membrane Disulfide bond Endoplasmic reticulum G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Synapse Transducer Transmembrane Transmembrane helix
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	Chrm3
otherIdentifier	10407591 12671 1422258_at 17290447 4398463 4631597 4717370 4752738 5136171 5347976 5364228 5389026 5493622 A_51_P247853 A_52_P92072 A_55_P1955681 GE41848 GO:0003012 GO:0004930 GO:0005515 GO:0005783 GO:0005789 GO:0005886 GO:0006939 GO:0006940 GO:0007165 GO:0007186 GO:0007187 GO:0007197 GO:0007207 GO:0007213 GO:0007268 GO:0007271 GO:0009925 GO:0016020 GO:0016323 GO:0016907 GO:0019722 GO:0022600 GO:0030054 GO:0030425 GO:0032024 GO:0042166 GO:0045202 GO:0045211 GO:0045987 GO:0046541 GO:0095500 GO:1990806 ILMN_1235355 ILMN_2655907 mMC011603
physicalEntity	[EntityWithAccessionedSequence:R-MMU-426550] Muscarinic acetylcholine receptor M3 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-399994] Chrm3 [plasma membrane] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12694119] UCSC:Q9ERZ3 Chrm3 [ReferenceDNASequence:12061623] NCBI Gene:12671 Chrm3 [ReferenceDNASequence:11977530] Monarch:12671 Chrm3 [ReferenceDNASequence:11887748] KEGG:mmu:12671 Chrm3 [ReferenceDNASequence:11347741] BioGPS Gene:12671 Chrm3
referenceTranscript	[ReferenceRNASequence:12571470] RefSeq:NM_033269.5 Chrm3 [ReferenceRNASequence:12571469] RefSeq:NM_001428369.1 Chrm3 [ReferenceRNASequence:12571468] RefSeq:NM_001428370.1 Chrm3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ACM3_MOUSE Q64055
sequenceLength	589
species	[Species:48892] Mus musculus
stId	uniprot:Q9ERZ3
url	http://purl.uniprot.org/uniprot/Q9ERZ3

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