UniProt:Q9ER74 Sall1

chain
  • chain:1-1322
checksum DF4FEF7FEA0B9F5C
comment
  • FUNCTION Transcriptional repressor involved in organogenesis (PubMed:11688560, PubMed:11836251). Plays an essential role in ureteric bud invasion during kidney development (PubMed:11688560).SUBUNIT May associate with NuRD histone deacetylase complex (HDAC) (PubMed:11836251). Interacts with components of HDAC complex including HDAC1, HDAC2, RBBP4, RBPP7, MTA1 and MTA2 (PubMed:11836251). Interacts with CCNQ (By similarity). Interacts with NSD2 (via PHD-type zinc fingers 1, 2 and 3) (PubMed:19483677).SUBCELLULAR LOCATION Expressed in the metanephric mesenchyme surrounding ureteric bud.DEVELOPMENTAL STAGE Expressed in embryonic heart (at protein level) (PubMed:19483677). At 11.5 dpc expressed in limb buds, ventromedial parts of otic vesicles, endocardium, and weakly in the spinal cord and the brain (PubMed:11688560). At 14.5 dpc expressed in limb buds, anorectal region, developing olfactory bulb, nose and eye. At 10.5 dpc, expressed in the nephrogenic primordium (PubMed:11688560). At 11.5 dpc, expressed in mesonephric tubules and Wolffian ducts, and in the metanephric mesenchyme surrounding the ureteric bud (PubMed:11688560). At 14.5 dpc, expressed in the mesenchyme around the ureteric buds and weakly in comma-shaped bodies of metanephric tubules, but not in glomeruli, in the cortical regions of the developing kidney (PubMed:11688560).DISRUPTION PHENOTYPE Death at P1 stage (PubMed:11688560). Newborns have either no kidneys or ureters, only one kidney or ureter, or two small kidneys (PubMed:11688560). The remnant kidneys have disorganized cortical structure, shrunken glomeruli, necrotic proximal tubules and multiple cysts (PubMed:11688560). At day 11.5, embryos have an incomplete ureteric bud outgrowth, fail to form tubules in the mesenchyme and show apoptosis of the mesenchyme (PubMed:11688560).SIMILARITY Belongs to the sal C2H2-type zinc-finger protein family.
crossReference
databaseName UniProt
dbId 101116
description
  • recommendedName: Sal-like protein 1 alternativeName: Zinc finger protein Spalt-3 shortName: Sal-3 shortName: mSal-3
displayName UniProt:Q9ER74 Sall1
geneName
  • Sall1
  • Sal3
identifier Q9ER74
isSequenceChanged false
keyword
  • DNA-binding
  • Isopeptide bond
  • Metal-binding
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Repressor
  • Transcription
  • Transcription regulation
  • Ubl conjugation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • Sall1
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SALL1_MOUSE
  • Q920R5
sequenceLength 1322
species [Species:48892] Mus musculus
stId uniprot:Q9ER74
url http://purl.uniprot.org/uniprot/Q9ER74
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