Reactome | UniProt:Q9EQ14 Il23a

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UniProt:Q9EQ14 Il23a Show undefined attributes

chain	signal peptide:1-21 chain:22-196
checksum	DAF4A318A2DD3B7C
comment	FUNCTION Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383, PubMed:11390512, PubMed:16670770). Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (By similarity). This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A (PubMed:19900478). In turn, participates in the early and effective intracellular bacterial clearance (PubMed:16157683). Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:16648837).SUBUNIT Heterodimer with IL12B; disulfide-linked (PubMed:11114383). The heterodimer is known as interleukin IL-23 (PubMed:11114383). Interacts with IL23R; this interaction enables recruitment of IL12RB1 (By similarity).INTERACTION Secreted upon association with IL12B.TISSUE SPECIFICITY Secreted by activated dendritic cells (at protein level). Detected in various tissues with higher expression in polarized Th1 cells and activated macrophages.INDUCTION Up-regulated in trigeminal glanglia after herpes simplex virus type 1 infection, in the lung of mice infected with mycobacteria or Klebsiella pneumoniae. Up-regulated in microglia by combined LPS and IFNG stimulation. Up-regulated by FASLG.DISRUPTION PHENOTYPE Mice have no overt phenotype but display compromised humoral and delayed-type hypersensitivity responses. They also have impaired secretion of IL17 and IL17F, higher susceptibility to Klebsiella pneumoniae and Citrobacter rodentium infection, do not develop experimentally-induced autoimmune encephalitis a mouse model of multiple sclerosis, collagen-induced arthritis a rodent model of rheumatoid arthritis and also spontaneous colitis induced by IL10 deficiency a rodent model of inflammatory bowel disease. Transgenic mice expressing Il23a ubiquitously display multiorgan inflammation and infertility, express acute phase genes, have impaired growth and dye prematurely.SIMILARITY Belongs to the IL-6 superfamily.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12380200] RefSeq:NP_112542.1 [DatabaseIdentifier:12270692] PRO:Q9EQ14 [DatabaseIdentifier:11930882] MGI:1932410 [DatabaseIdentifier:11700311] ENSEMBL:ENSMUST00000026449 [DatabaseIdentifier:11577612] ENSEMBL:ENSMUSP00000026449 [DatabaseIdentifier:11477833] ENSEMBL:ENSMUSG00000025383
databaseName	UniProt
dbId	232650
description	recommendedName: Interleukin-23 subunit alpha shortName: IL-23 subunit alpha shortName: IL-23-A alternativeName: Interleukin-23 subunit p19 shortName: IL-23p19
displayName	UniProt:Q9EQ14 Il23a
geneName	Il23a
identifier	Q9EQ14
isSequenceChanged	false
keyword	Antiviral defense Cytokine Disulfide bond Immunity Inflammatory response Innate immunity Reference proteome Secreted Signal Tissue remodeling
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	Il23a
otherIdentifier	10373358 1419529_at 17246091 4579596 4967547 5005936 5007019 5235887 5271998 5464474 5498435 83430 A_52_P649817 GE125734 GO:0001916 GO:0002230 GO:0002376 GO:0002827 GO:0005125 GO:0005515 GO:0005576 GO:0005615 GO:0006355 GO:0006954 GO:0006955 GO:0007259 GO:0010468 GO:0010557 GO:0032693 GO:0032725 GO:0032729 GO:0032733 GO:0032735 GO:0032740 GO:0032760 GO:0032819 GO:0042098 GO:0042102 GO:0042104 GO:0043382 GO:0045087 GO:0045519 GO:0045672 GO:0045944 GO:0046635 GO:0048018 GO:0048771 GO:0050829 GO:0051135 GO:0051142 GO:0051607 GO:0070743 GO:0080090 GO:0090023 GO:0097696 GO:0098542 GO:0098772 GO:1902107 GO:2000318 GO:2000330 ILMN_2671320 ILMN_2799748 mMC013096
physicalEntity	[EntityWithAccessionedSequence:R-MMU-8950224] Il23a [endoplasmic reticulum lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-8950470] Il23a [extracellular region] - Mus musculus [EntityWithAccessionedSequence:R-MMU-447245] Il23a [extracellular region] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12690812] UCSC:Q9EQ14 Il23a [ReferenceDNASequence:12057180] NCBI Gene:83430 Il23a [ReferenceDNASequence:11973087] Monarch:83430 Il23a [ReferenceDNASequence:11883789] KEGG:mmu:83430 Il23a [ReferenceDNASequence:11343298] BioGPS Gene:83430 Il23a
referenceTranscript	[ReferenceRNASequence:12562004] RefSeq:NM_031252.2 Il23a
schemaClass	ReferenceGeneProduct
secondaryIdentifier	IL23A_MOUSE
sequenceLength	196
species	[Species:48892] Mus musculus
stId	uniprot:Q9EQ14
url	http://purl.uniprot.org/uniprot/Q9EQ14

Referrals

(interactor)	[UndirectedInteraction:11301081] UniProt:Q9EQ14 <-> UniProt:P43432 (IntAct) [UndirectedInteraction:11293541] UniProt:P29460 <-> UniProt:Q9EQ14 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-MMU-8950224] Il23a [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-MMU-8950470] Il23a [extracellular region] [EntityWithAccessionedSequence:R-MMU-447245] Il23a [extracellular region]

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