UniProt:Q9DBG5 Plin3

chain
  • initiator methionine:1
  • chain:2-437
checksum F7CDD3A754A5C04D
comment
  • FUNCTION Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.SUBUNIT Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain).INTERACTION Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails.PTM Phosphorylation at Tyr-255 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.SIMILARITY Belongs to the perilipin family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 236440
description
  • recommendedName: Perilipin-3 alternativeName: fullName evidence="3"Cargo selection protein TIP47 alternativeName: Mannose-6-phosphate receptor-binding protein 1
displayName UniProt:Q9DBG5 Plin3
geneName
  • Plin3
  • M6prbp1
  • Tip47
identifier Q9DBG5
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Coiled coil
  • Cytoplasm
  • Endosome
  • Isopeptide bond
  • Lipid droplet
  • Membrane
  • Phosphoprotein
  • Reference proteome
  • Transport
  • Ubl conjugation
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • Plin3
otherIdentifier
  • 10452030
  • 1416424_at
  • 17346216
  • 4316807
  • 4492052
  • 4496761
  • 4525127
  • 4525464
  • 4528624
  • 4594302
  • 4598628
  • 4647299
  • 4938712
  • 5118422
  • 5208110
  • 5242287
  • 5259403
  • 5299863
  • 5410223
  • 5508291
  • 5572402
  • 66905
  • A_51_P223404
  • GE40967
  • GO:0005515
  • GO:0005737
  • GO:0005768
  • GO:0005811
  • GO:0005829
  • GO:0010008
  • GO:0010890
  • GO:0016020
  • GO:0019915
  • GO:0042149
  • GO:0043226
  • GO:1905691
  • ILMN_1245528
  • mMC009278
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PLIN3_MOUSE
  • Q3TK05
  • Q8BKV9
  • Q9CZK1
sequenceLength 437
species [Species:48892] Mus musculus
stId uniprot:Q9DBG5
url http://purl.uniprot.org/uniprot/Q9DBG5
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