UniProt:Q9CR24 Nudt8

chain
  • chain:1-210
checksum 2E153033C466A6FE
comment
  • FUNCTION Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products (PubMed:31004344). Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA (PubMed:31004344). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673).CATALYTIC ACTIVITY an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY acetyl-CoA + H2O = S-acetyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY hexanoyl-CoA + H2O = hexanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY propanoyl-CoA + H2O = propanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY malonyl-CoA + H2O = malonyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY succinyl-CoA + H2O = succinyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY a 5'-end CoA-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + (R)-4'-phosphopantetheine + 2 H(+)COFACTOR Monomer.SUBCELLULAR LOCATION Expressed at the highest levels in the kidneys, heart, brown adipose tissue and liver (at protein level) (PubMed:31004344). Expressed at lower levels in the brain, skeletal muscle, and white adipose tissue (at protein level) (PubMed:31004344).SIMILARITY Belongs to the Nudix hydrolase family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 240766
description
  • recommendedName: Mitochondrial coenzyme A diphosphatase NUDT8 ecNumber: 3.6.1.- ecNumber evidence="3"3.6.1.77 alternativeName: Nucleoside diphosphate-linked moiety X motif 8 shortName: Nudix motif 8
displayName UniProt:Q9CR24 Nudt8
geneName
  • Nudt8
identifier Q9CR24
isSequenceChanged false
keyword
  • Hydrolase
  • Magnesium
  • Manganese
  • Metal-binding
  • Mitochondrion
  • Reference proteome
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • Nudt8
otherIdentifier
  • 10460285
  • 10460291
  • 105812_at
  • 1450111_a_at
  • 1450707_at
  • 17356061
  • 17356070
  • 4349099
  • 4411468
  • 4485644
  • 4517052
  • 4692046
  • 4705557
  • 4709071
  • 4829437
  • 4844871
  • 4891644
  • 4949643
  • 4949831
  • 5030963
  • 5066831
  • 5078054
  • 5184628
  • 5217217
  • 5218468
  • 5226266
  • 5263714
  • 5307788
  • 5344168
  • 5413251
  • 5433217
  • 5494075
  • 5556857
  • 5558210
  • 5588501
  • 5596113
  • 5607013
  • 5615294
  • 66387
  • A_51_P490388
  • A_52_P475439
  • GE40804
  • GO:0000287
  • GO:0003674
  • GO:0005739
  • GO:0005759
  • GO:0006629
  • GO:0006790
  • GO:0008150
  • GO:0010945
  • GO:0015938
  • GO:0016787
  • GO:0030145
  • GO:0036114
  • GO:0044580
  • GO:0046356
  • GO:0046872
  • GO:0055086
  • GO:1901289
  • GO:1902859
  • GO:2001294
  • ILMN_2617305
  • ILMN_2704429
  • mMC009382
  • mMC012104
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NUDT8_MOUSE
  • Q3TDQ2
sequenceLength 210
species [Species:48892] Mus musculus
stId uniprot:Q9CR24
url http://purl.uniprot.org/uniprot/Q9CR24
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