Reactome | UniProt:Q9C0C6 CIPC

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UniProt:Q9C0C6 CIPC Show undefined attributes

chain	chain:1-399
checksum	A02AE8F6543781D9
comment	FUNCTION Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiological relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock.SUBUNIT Interacts with CLOCK. Forms a ternary complex with the CLOCK-BMAL1 heterodimer. Interacts with CAD and HSPA5 (PubMed:26657846).INTERACTION Predominantly localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S boundary, partially translocated to the cytosol.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12348063] RefSeq:NP_219494.2 [DatabaseIdentifier:12294101] Pharos - Targets:Q9C0C6 [DatabaseIdentifier:12256425] PRO:Q9C0C6 [DatabaseIdentifier:12133936] OpenTargets:ENSG00000198894 [DatabaseIdentifier:11849240] HPA:ENSG00000198894-CIPC [DatabaseIdentifier:11796272] GeneCards:CIPC [DatabaseIdentifier:11680931] ENSEMBL:ENST00000361786 [DatabaseIdentifier:11558232] ENSEMBL:ENSP00000355319 [DatabaseIdentifier:11463617] ENSEMBL:ENSG00000198894
databaseName	UniProt
dbId	233772
description	recommendedName: CLOCK-interacting pacemaker alternativeName: CLOCK-interacting circadian protein
displayName	UniProt:Q9C0C6 CIPC
geneName	CIPC KIAA1737
identifier	Q9C0C6
isSequenceChanged	false
keyword	Biological rhythms Coiled coil Cytoplasm Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	CIPC
otherIdentifier	11720196_at 16786858 225623_PM_at 225623_at 3545312 3545313 3545314 3545315 3545318 3545319 3545320 3545321 65543_at 7975926 85457 A_14_P106212 A_14_P107257 A_14_P138157 A_23_P372925 GE85518 GO:0005515 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006355 GO:0042754 GO:0045892 GO:0048511 HMNXSV003004542 Hs.22452.0.S1_3p_at ILMN_1788347 ILMN_2097858 PH_hs_0001962 TC14002201.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9911267] CIPC [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12733142] UCSC:Q9C0C6 CIPC [ReferenceDNASequence:12118148] OMIM:616995 CIPC [ReferenceDNASequence:12041864] NCBI Gene:85457 CIPC [ReferenceDNASequence:11957771] Monarch:85457 CIPC [ReferenceDNASequence:11870179] KEGG:hsa:85457 CIPC [ReferenceDNASequence:11827979] HGNC:20365 CIPC [ReferenceDNASequence:11435659] dbSNP Gene:85457 CIPC [ReferenceDNASequence:11425467] CTD Gene:85457 CIPC [ReferenceDNASequence:11398791] COSMIC - genes:CIPC CIPC [ReferenceDNASequence:11327982] BioGPS Gene:85457 CIPC [ReferenceDNASequence:ensembl:ENSG00000198894] ENSEMBL:ENSG00000198894 CIPC
referenceTranscript	[ReferenceRNASequence:12529922] RefSeq:NM_033426.2 CIPC
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CIPC_HUMAN B2RCI1 Q8N389 Q8NDZ1
sequenceLength	399
species	[Species:48887] Homo sapiens
stId	uniprot:Q9C0C6
url	http://purl.uniprot.org/uniprot/Q9C0C6

Referrals

(interactor)	[UndirectedInteraction:11304811] UniProt:Q92905 <-> UniProt:Q9C0C6 (IntAct) [UndirectedInteraction:11215209] UniProt:O43639 <-> UniProt:Q9C0C6 (IntAct) [UndirectedInteraction:11161899] UniProt:O15516 <-> UniProt:Q9C0C6 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-9911267] CIPC [nucleoplasm]