UniProt:Q9C005 DPY30

chain
  • chain:1-99
checksum 5356AC515B9C2ADB
comment
  • FUNCTION As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.SUBUNIT Homodimer. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity). Interacts with ASH2L; the interaction is direct. Interacts with ARFGEF1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.INTERACTION Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs (By similarity).SIMILARITY Belongs to the dpy-30 family.
crossReference
databaseName UniProt
dbId 53818
description
  • recommendedName: Protein dpy-30 homolog alternativeName: Dpy-30-like protein shortName: Dpy-30L
displayName UniProt:Q9C005 DPY30
geneName
  • DPY30
identifier Q9C005
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Chromatin regulator
  • Golgi apparatus
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • DPY30
otherIdentifier
  • 11744777_s_at
  • 11755170_s_at
  • 11757820_a_at
  • 11762957_x_at
  • 1555522_PM_s_at
  • 1555522_s_at
  • 16896279
  • 219065_PM_s_at
  • 219065_s_at
  • 224129_PM_s_at
  • 224129_s_at
  • 2547334
  • 2547335
  • 2547336
  • 2547337
  • 2547339
  • 2547343
  • 2547350
  • 2547356
  • 2547357
  • 2547359
  • 2547360
  • 2547380
  • 2547387
  • 2547388
  • 2547389
  • 2547390
  • 2547391
  • 2547392
  • 2547393
  • 2547395
  • 2547399
  • 2547400
  • 2547402
  • 2547403
  • 2547404
  • 2547405
  • 2547415
  • 2547417
  • 2926735
  • 2926736
  • 3449951
  • 3449952
  • 3919822
  • 3919823
  • 50305_at
  • 8051372
  • 8051387
  • 8068410
  • 84661
  • A_23_P5389
  • A_32_P143880
  • GE62591
  • GE79574
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005794
  • GO:0005802
  • GO:0006325
  • GO:0016192
  • GO:0016197
  • GO:0035097
  • GO:0042802
  • GO:0042803
  • GO:0044665
  • GO:0044666
  • GO:0045815
  • GO:0048188
  • GO:0071339
  • HMNXSV003003600
  • HMNXSV003010605
  • HMNXSV003017838
  • Hs2.20814.2.S1_3p_s_at
  • ILMN_1741599
  • ILMN_1790819
  • ILMN_2131880
  • ILMN_2131882
  • PH_hs_0027433
  • PH_hs_0032826
  • TC02004154.hg
  • TC02005024.hg
  • g12655885_3p_a_at
  • g7705719_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DPY30_HUMAN
  • D6W578
sequenceLength 99
species [Species:48887] Homo sapiens
stId uniprot:Q9C005
url http://purl.uniprot.org/uniprot/Q9C005

Referrals

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