UniProt:Q9BYE7 PCGF6

chain
  • chain:1-350
checksum 05977FE6F14972DE
comment
  • FUNCTION Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).SUBUNIT Component of a PRC1-like complex (PubMed:19636380, PubMed:26151332). Interacts with BMI1/PCGF4, RING1 and RNF2 (PubMed:12167161). Interacts with KDM5D (PubMed:17320162). Interacts with CBX4, CBX6, CBX7 and CBX8 (PubMed:21282530).INTERACTION Ubiquitous.PTM Phosphorylated during mitosis. Phosphorylated on Ser-30 by CDK7 in vitro.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 242050
description
  • recommendedName: Polycomb group RING finger protein 6 alternativeName: Mel18 and Bmi1-like RING finger alternativeName: RING finger protein 134
displayName UniProt:Q9BYE7 PCGF6
geneName
  • PCGF6
  • MBLR
  • RNF134
identifier Q9BYE7
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Coiled coil
  • Isopeptide bond
  • Metal-binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
  • Ubl conjugation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • PCGF6
otherIdentifier
  • 11724980_s_at
  • 16718022
  • 224326_PM_s_at
  • 224326_s_at
  • 3304719
  • 3304720
  • 3304722
  • 3304724
  • 3304726
  • 3304727
  • 3304728
  • 3304729
  • 3304730
  • 3304731
  • 3304732
  • 3304733
  • 3304734
  • 3304735
  • 3304736
  • 3304741
  • 3826917
  • 3826919
  • 3826920
  • 3826921
  • 3826922
  • 3826923
  • 3826924
  • 3826925
  • 3826926
  • 3826928
  • 3826932
  • 61670_at
  • 7936083
  • 8027330
  • 84108
  • A_23_P115703
  • GE83323
  • GO:0000122
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0006325
  • GO:0006338
  • GO:0006355
  • GO:0006357
  • GO:0008270
  • GO:0031519
  • GO:0035102
  • GO:0045892
  • GO:0046872
  • HMNXSV003045773
  • HMNXSV003053455
  • ILMN_1656574
  • ILMN_1810181
  • ILMN_2401701
  • PH_hs_0029782
  • TC10001628.hg
  • g13537205_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PCGF6_HUMAN
  • A8K3R4
  • Q5SYD1
  • Q5SYD6
  • Q96ID9
  • Q96SJ1
sequenceLength 350
species [Species:48887] Homo sapiens
stId uniprot:Q9BYE7
url http://purl.uniprot.org/uniprot/Q9BYE7

Referrals

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