UniProt:Q9BYC5 FUT8

chain
  • chain:1-575
checksum 5AE24A93881E18D0
comment
  • FUNCTION Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans (PubMed:17172260, PubMed:29304374, PubMed:36280670, PubMed:9133635). Fucosylates the reducing GlcNAc residue in complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs. Fully converts Fc glycoforms containing one or two terminal GlcNAc moieties (G0-GlcNAc and G0) (PubMed:36280670).CATALYTIC ACTIVITY N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP-beta-L-fucose = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP + H(+)CATALYTIC ACTIVITY an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP-beta-L-fucose = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP + H(+)PATHWAY Protein modification; protein glycosylation.INTERACTION Membrane-bound form in trans cisternae of Golgi.ALTERNATIVE PRODUCTS Tyrosine phosphorylated by PKDCC/VLK.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Seems to be only expressed in retina, inactive as a fucosyltransferase.SIMILARITY Belongs to the glycosyltransferase 23 family.ONLINE INFORMATION Fucosyltransferase 8
crossReference
databaseName UniProt
dbId 55052
description
  • recommendedName: Alpha-(1,6)-fucosyltransferase shortName: Alpha1-6FucT ecNumber evidence="7 11"2.4.1.68 alternativeName: Fucosyltransferase 8 alternativeName: GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase alternativeName: GDP-fucose--glycoprotein fucosyltransferase alternativeName: Glycoprotein 6-alpha-L-fucosyltransferase
displayName UniProt:Q9BYC5 FUT8
geneName
  • FUT8
identifier Q9BYC5
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Congenital disorder of glycosylation
  • Disease variant
  • Disulfide bond
  • Glycosyltransferase
  • Golgi apparatus
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • SH3 domain
  • SH3-binding
  • Signal-anchor
  • Transferase
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • FUT8
otherIdentifier
  • 11741568_a_at
  • 11749723_a_at
  • 1554930_PM_a_at
  • 1554930_a_at
  • 16785483
  • 203988_PM_s_at
  • 203988_s_at
  • 2530
  • 3540496
  • 3540553
  • 3540554
  • 3540555
  • 3540556
  • 3540561
  • 3540563
  • 3540564
  • 3540568
  • 3540572
  • 3540573
  • 3540574
  • 3540575
  • 3540576
  • 3540585
  • 3540586
  • 3540588
  • 3540592
  • 3540595
  • 3540605
  • 3540606
  • 3540614
  • 3540615
  • 3540616
  • 3540618
  • 3540623
  • 3540624
  • 3540625
  • 3540626
  • 3540627
  • 3540628
  • 3540669
  • 41628_at
  • 42282_at
  • 7975136
  • A_14_P109106
  • A_14_P113075
  • A_23_P313632
  • D89289_at
  • GE60337
  • GO:0000139
  • GO:0001701
  • GO:0003824
  • GO:0005515
  • GO:0005794
  • GO:0005975
  • GO:0006486
  • GO:0006487
  • GO:0006491
  • GO:0007179
  • GO:0007229
  • GO:0007585
  • GO:0008424
  • GO:0009312
  • GO:0010468
  • GO:0010761
  • GO:0016020
  • GO:0016477
  • GO:0016740
  • GO:0016757
  • GO:0016758
  • GO:0017124
  • GO:0018279
  • GO:0019082
  • GO:0032580
  • GO:0036071
  • GO:0042355
  • GO:0043112
  • GO:0046368
  • GO:0046921
  • GO:0048856
  • GO:0048870
  • GO:0055086
  • GO:0070062
  • GO:0140096
  • GO:1900407
  • GO:1901135
  • HMNXSV003010961
  • Hs2.118722.3.S1_3p_s_at
  • ILMN_1693152
  • ILMN_1741422
  • PH_hs_0006549
  • TC14000397.hg
  • TC14001735.hg
  • g4758407_3p_a_at
  • p33676
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • FUT8_HUMAN
  • B4DFS7
  • G3V5N0
  • O00235
  • Q8IUA5
  • Q9BYC6
  • Q9P2U5
  • Q9P2U6
sequenceLength 575
species [Species:48887] Homo sapiens
stId uniprot:Q9BYC5
url http://purl.uniprot.org/uniprot/Q9BYC5
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