UniProt:Q9BXP5 SRRT

chain
  • initiator methionine:1
  • chain:2-876
checksum EB3ABD1325EA98D9
comment
  • FUNCTION Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).SUBUNIT Interacts with NCBP1 and DROSHA (By similarity). Interacts with CASP8AP2 and ERBB4. Interacts with LUZP4. Interacts with NCBP2/CBP20 and NCBP3 (PubMed:26382858). Interacts with MTREX (PubMed:30842217).INTERACTION Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity).ALTERNATIVE PRODUCTS Ubiquitously expressed.SIMILARITY Belongs to the ARS2 family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
crossReference
databaseName UniProt
dbId 50325
description
  • recommendedName: Serrate RNA effector molecule homolog alternativeName: Arsenite-resistance protein 2
displayName UniProt:Q9BXP5 SRRT
geneName
  • SRRT
  • ARS2
  • ASR2
identifier Q9BXP5
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Activator
  • Alternative splicing
  • Cytoplasm
  • Isopeptide bond
  • Methylation
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • RNA-mediated gene silencing
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • SRRT
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SRRT_HUMAN
  • A4D2E5
  • A4D2E6
  • A6NK22
  • B4DJL4
  • B4DZA6
  • O95808
  • Q32MI4
  • Q6NT74
  • Q8TDQ5
  • Q9BWP6
  • Q9BXP4
  • Q9Y4S4
sequenceLength 876
species [Species:48887] Homo sapiens
stId uniprot:Q9BXP5
url http://purl.uniprot.org/uniprot/Q9BXP5
Cite Us!