UniProt:Q9BWF2 TRAIP

chain
  • chain:1-469
checksum B9EF3808FBC5985B
comment
  • FUNCTION E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:25335891, PubMed:26595769, PubMed:26711499, PubMed:26781088, PubMed:27462463, PubMed:31545170). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is however controversial (PubMed:26595769). Acts as a regulator of the spindle assembly checkpoint (PubMed:25335891). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts (via PIP-box) with PCNA (PubMed:26711499, PubMed:27462463). Binds TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 is part of the receptor-TRAF signaling complex (PubMed:17544371). May interact with CYLD; the C-terminus interacts with CYLD, however the interaction was not detected with the full-length protein (PubMed:14676304). Interacts with POLK and POLN (PubMed:24553286). Interacts with UIMC1 (PubMed:26781088).INTERACTION In the nucleus, found in close proximity to PCNA, suggesting localization at replication foci (PubMed:26595769). Localizes to DNA damage sites in response to replication stress (PubMed:26595769, PubMed:26711499, PubMed:26781088).PTM Sumoylated; sumoylation is required for nuclear localization (PubMed:26820530). Sumoylation increases protein stability, possibly by preventing ubiquitination (PubMed:26820530).PTM Autoubiquitinated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TRAIP family.
crossReference
databaseName UniProt
dbId 103806
description
  • recommendedName: fullName evidence="20"E3 ubiquitin-protein ligase TRAIP ecNumber evidence="6 7"2.3.2.27 alternativeName: fullName evidence="18"RING finger protein 206 alternativeName: fullName evidence="17 19"TRAF-interacting protein
displayName UniProt:Q9BWF2 TRAIP
geneName
  • TRAIP
  • RNF206
  • TRIP
identifier Q9BWF2
isSequenceChanged false
keyword
  • 3D-structure
  • Chromosome
  • Coiled coil
  • Cytoplasm
  • Disease variant
  • DNA damage
  • DNA repair
  • Dwarfism
  • Intellectual disability
  • Isopeptide bond
  • Metal-binding
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transferase
  • Ubl conjugation
  • Ubl conjugation pathway
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • TRAIP
otherIdentifier
  • 10293
  • 11755941_a_at
  • 11762212_at
  • 16954251
  • 205598_PM_at
  • 205598_at
  • 2674809
  • 2674810
  • 2674811
  • 2674812
  • 2674813
  • 2674814
  • 2674815
  • 2674816
  • 2674818
  • 2674820
  • 2674821
  • 2674823
  • 2674824
  • 2674825
  • 2674827
  • 2674828
  • 2674829
  • 2674830
  • 2674831
  • 2674832
  • 2674833
  • 2674834
  • 2674835
  • 2674836
  • 2674838
  • 2674839
  • 2674840
  • 2674841
  • 38953_at
  • 8087513
  • A_23_P170491
  • GE81571
  • GO:0003824
  • GO:0004842
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005694
  • GO:0005730
  • GO:0005737
  • GO:0006281
  • GO:0006915
  • GO:0006974
  • GO:0007165
  • GO:0008270
  • GO:0010804
  • GO:0016567
  • GO:0016740
  • GO:0031297
  • GO:0032688
  • GO:0042802
  • GO:0046872
  • GO:0048471
  • GO:0061630
  • GO:0090734
  • GO:0106300
  • GO:0140096
  • HMNXSV003003933
  • ILMN_1715540
  • TC03001419.hg
  • U77845_at
  • g5032194_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TRAIP_HUMAN
  • B5BU84
  • B5BUL3
  • O00467
sequenceLength 469
species [Species:48887] Homo sapiens
stId uniprot:Q9BWF2
url http://purl.uniprot.org/uniprot/Q9BWF2
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