UniProt:Q9BV40 VAMP8

chain
  • chain:1-100
checksum 018B986442BBD9B6
comment
  • FUNCTION SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Also plays a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity). Also participates in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (PubMed:31694946).SUBUNIT Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome (PubMed:25686604, PubMed:37821429). Found in a number of SNARE complexes with NAPA, SNAP23, SNAP25, STX1A, STX4, STX7, STX8 and VTI1B (PubMed:12130530). Interacts with PICALM (By similarity). SNARE complex formation and binding by PICALM are mutually exclusive processes for VAMP8 (By similarity). Interacts with SBF2/MTMR13 (PubMed:25648148). Interacts with RAB21 (in GTP-bound form) in response to starvation; the interaction probably regulates VAMP8 endolysosomal trafficking (PubMed:25648148). Interacts with STX17; this interaction is increased in the absence of TMEM39A (PubMed:31806350, PubMed:33422265). Interacts with TRIM6 (PubMed:31694946). Interacts with RAB44; VAMP8 may act as RAB44 effector in mast cell degranulation (By similarity).SUBUNIT (Microbial infection) The interaction with STX17 is decreased in presence of SARS coronavirus-2/SARS-CoV-2 ORF3A protein.INTERACTION Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (By similarity). Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell (By similarity). Cycles through the apical but not through the basolateral plasma membrane (By similarity). Apical region of acinar cells; in zymogen granule membranes (By similarity).TISSUE SPECIFICITY Platelets.PTM (Microbial infection) Stearoylated By S.flexneri N-epsilon-fatty acyltransferase IcsB, thereby disrupting the host actin cytoskeleton.SIMILARITY Belongs to the synaptobrevin family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 254069
description
  • recommendedName: fullName evidence="15"Vesicle-associated membrane protein 8 shortName evidence="15"VAMP-8 alternativeName: fullName evidence="16"Endobrevin shortName evidence="16"EDB
displayName UniProt:Q9BV40 VAMP8
geneName
  • VAMP8
identifier Q9BV40
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Antiviral defense
  • Autophagy
  • Cell membrane
  • Coiled coil
  • Cytoplasmic vesicle
  • Direct protein sequencing
  • Endosome
  • Lipoprotein
  • Lysosome
  • Membrane
  • Phosphoprotein
  • Protein transport
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • VAMP8
otherIdentifier
  • 11717012_s_at
  • 16882277
  • 202546_PM_at
  • 202546_at
  • 2491662
  • 2491663
  • 2491667
  • 2491668
  • 2491669
  • 2491670
  • 2491671
  • 2491672
  • 2491673
  • 2491675
  • 32715_at
  • 49686_s_at
  • 8043197
  • 8673
  • A_14_P129859
  • A_23_P28434
  • GE61583
  • GO:0005484
  • GO:0005515
  • GO:0005737
  • GO:0005764
  • GO:0005765
  • GO:0005768
  • GO:0005769
  • GO:0005829
  • GO:0005886
  • GO:0006906
  • GO:0006914
  • GO:0012505
  • GO:0015031
  • GO:0016020
  • GO:0016192
  • GO:0016240
  • GO:0019869
  • GO:0019905
  • GO:0030667
  • GO:0030669
  • GO:0030670
  • GO:0031201
  • GO:0031410
  • GO:0031901
  • GO:0031902
  • GO:0031982
  • GO:0035493
  • GO:0035577
  • GO:0035579
  • GO:0042589
  • GO:0043226
  • GO:0043933
  • GO:0046718
  • GO:0048471
  • GO:0051607
  • GO:0055037
  • GO:0055038
  • GO:0060090
  • GO:0061024
  • GO:0065003
  • GO:0070062
  • GO:0070254
  • GO:0070821
  • GO:0097352
  • GO:0098542
  • GO:0098594
  • GO:0098772
  • GO:1903076
  • GO:1903531
  • GO:1903595
  • HMNXSV003027198
  • ILMN_2190084
  • PH_hs_0010333
  • TC02000512.hg
  • g4507864_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • VAMP8_HUMAN
  • O60625
  • Q53SP9
  • Q6IB09
sequenceLength 100
species [Species:48887] Homo sapiens
stId uniprot:Q9BV40
url http://purl.uniprot.org/uniprot/Q9BV40

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