Reactome | UniProt:Q9BUF5 TUBB6

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UniProt:Q9BUF5 TUBB6 Show undefined attributes

chain	chain:1-446
checksum	E9884AC2BD676BB2
comment	FUNCTION Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.COFACTOR Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.INTERACTION Ubiquitous. Maximal expression in breast and lung, where it represents around 10% of all beta-tubulins. Largely decreased expression in most cancerous tissues.DOMAIN The highly acidic C-terminal region may bind cations such as calcium.DOMAIN The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.PTM Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Glutamylation is also involved in cilia motility (By similarity).PTM Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into cilia and flagella axonemes, which is required for their stability and maintenance. Flagella glycylation controls sperm motility. Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally.PTM Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the tubulin family.
created	[InstanceEdit:191695] Matthews, L, 2007-01-23 08:35:49
crossReference	[DatabaseIdentifier:11504766] ENSEMBL:ENSG00000176014 [DatabaseIdentifier:11617008] ENSEMBL:ENSP00000318697 [DatabaseIdentifier:11739707] ENSEMBL:ENST00000317702 [DatabaseIdentifier:11781913] GeneCards:TUBB6 [DatabaseIdentifier:11797610] GlyGen:Q9BUF5 [DatabaseIdentifier:11829376] HMDB Protein:HMDBP08049 [DatabaseIdentifier:11835036] HPA:ENSG00000176014-TUBB6 [DatabaseIdentifier:12119488] OpenTargets:ENSG00000176014 [DatabaseIdentifier:12257998] PRO:Q9BUF5 [DatabaseIdentifier:12279825] Pharos - Targets:Q9BUF5 [DatabaseIdentifier:12438961] RefSeq:NP_001290458.1 [DatabaseIdentifier:12438965] RefSeq:NP_001290454.1 [DatabaseIdentifier:12438959] RefSeq:NP_001290457.1 [DatabaseIdentifier:12438958] RefSeq:NP_001290459.1 [DatabaseIdentifier:12438960] RefSeq:NP_115914.1 [DatabaseIdentifier:12438964] RefSeq:NP_001290453.1 [DatabaseIdentifier:12438962] RefSeq:NP_001290455.1 [DatabaseIdentifier:12438963] RefSeq:NP_001290456.1
databaseName	UniProt
dbId	191706
description	recommendedName: Tubulin beta-6 chain alternativeName: Tubulin beta class V
displayName	UniProt:Q9BUF5 TUBB6
geneName	TUBB6
identifier	Q9BUF5
isSequenceChanged	false
keyword	Cytoplasm Cytoskeleton Disease variant GTP-binding Isopeptide bond Magnesium Metal-binding Microtubule Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	TUBB6
otherIdentifier	11715932_s_at 11747072_s_at 16851081 209191_PM_at 209191_at 2916784 33678_i_at 3779578 3779580 3779581 3779582 3779583 3779584 3779589 3779590 3779591 3779592 3779593 3779594 3779597 4040647 4040672 43355_s_at 72977_at 72979_g_at 8020220 84617 A_23_P254271 A_24_P313756 GE61273 GO:0000166 GO:0000226 GO:0000278 GO:0003924 GO:0005198 GO:0005200 GO:0005515 GO:0005525 GO:0005634 GO:0005737 GO:0005856 GO:0005874 GO:0007010 GO:0007017 GO:0015630 GO:0016787 GO:0043226 GO:0045171 GO:0046872 GO:0070062 GO:0072686 HMNXSV003052532 ILMN_1699489 ILMN_1702636 PH_hs_0014153 TC18000064.hg g12803638_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-191698] TUBB6 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5610438] TUBB6 [axonemal microtubule] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8867399] Polyglutamyl-TUBB6 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8867396] Polyglycyl-TUBB6 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-392780] TUBB6 unfolded [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-392787] TUBB6 folding intermediate [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000176014] ENSEMBL:ENSG00000176014 TUBB6 [ReferenceDNASequence:12759718] UCSC:Q9BUF5 TUBB6 [ReferenceDNASequence:11370325] BioGPS Gene:84617 TUBB6 [ReferenceDNASequence:11402437] COSMIC - genes:TUBB6 TUBB6 [ReferenceDNASequence:11405103] CTD Gene:84617 TUBB6 [ReferenceDNASequence:11439922] dbSNP Gene:84617 TUBB6 [ReferenceDNASequence:11813514] HGNC:20776 TUBB6 [ReferenceDNASequence:11908469] KEGG:hsa:84617 TUBB6 [ReferenceDNASequence:12000114] Monarch:84617 TUBB6 [ReferenceDNASequence:12084207] NCBI Gene:84617 TUBB6 [ReferenceDNASequence:12105381] OMIM:615103 TUBB6
referenceTranscript	[ReferenceRNASequence:12620475] RefSeq:NM_001303527.1 TUBB6 [ReferenceRNASequence:12620479] RefSeq:NM_001303524.1 TUBB6 [ReferenceRNASequence:12620478] RefSeq:NM_032525.3 TUBB6 [ReferenceRNASequence:12620480] RefSeq:NM_001303526.1 TUBB6 [ReferenceRNASequence:12620476] RefSeq:NM_001303529.1 TUBB6 [ReferenceRNASequence:12620481] RefSeq:NM_001303525.1 TUBB6 [ReferenceRNASequence:12620474] RefSeq:NM_001303528.1 TUBB6 [ReferenceRNASequence:12620477] RefSeq:NM_001303530.1 TUBB6
schemaClass	ReferenceGeneProduct
secondaryIdentifier	TBB6_HUMAN B3KM76 Q9HA42
sequenceLength	446
species	[Species:48887] Homo sapiens
stId	uniprot:Q9BUF5
url	http://purl.uniprot.org/uniprot/Q9BUF5

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-191698] TUBB6 [cytosol] [EntityWithAccessionedSequence:R-HSA-5610438] TUBB6 [axonemal microtubule] [EntityWithAccessionedSequence:R-HSA-8867399] Polyglutamyl-TUBB6 [cytosol] [EntityWithAccessionedSequence:R-HSA-8867396] Polyglycyl-TUBB6 [cytosol] [EntityWithAccessionedSequence:R-HSA-392780] TUBB6 unfolded [cytosol] [EntityWithAccessionedSequence:R-HSA-392787] TUBB6 folding intermediate [cytosol]
(referenceSequence)	[ModifiedResidue:8867394] L-isoglutamyl-polyglutamic acid at unknown position [ModifiedResidue:8867375] L-isoglutamyl-polyglycine at unknown position
(interactor)	[UndirectedInteraction:11147701] UniProt:P13569 <-> UniProt:Q9BUF5 (IntAct) [UndirectedInteraction:11182971] UniProt:P04792 <-> UniProt:Q9BUF5 (IntAct) [UndirectedInteraction:11218891] UniProt:P10636-8 <-> UniProt:Q9BUF5 (IntAct) [UndirectedInteraction:11225719] UniProt:P03372 <-> UniProt:Q9BUF5 (IntAct) [UndirectedInteraction:11226475] UniProt:P42858 <-> UniProt:Q9BUF5 (IntAct) [UndirectedInteraction:11238777] UniProt:O76024 <-> UniProt:Q9BUF5 (IntAct) [UndirectedInteraction:11305461] UniProt:Q5S007 <-> UniProt:Q9BUF5 (IntAct)