Reactome | UniProt:Q9BSB4 ATG101

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UniProt:Q9BSB4 ATG101 Show undefined attributes

chain	chain:1-218
checksum	69A881EAF9A07659
comment	FUNCTION Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.SUBUNIT Interacts with ATG13 (PubMed:19287211, PubMed:19597335, PubMed:26299944). Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13 (PubMed:19287211, PubMed:19597335).INTERACTION Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.SIMILARITY Belongs to the ATG101 family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12442444] RefSeq:NP_001092143.1 [DatabaseIdentifier:12442445] RefSeq:XP_054228802.1 [DatabaseIdentifier:12442446] RefSeq:NP_068753.2 [DatabaseIdentifier:12442443] RefSeq:XP_024304888.1 [DatabaseIdentifier:12281248] Pharos - Targets:Q9BSB4 [DatabaseIdentifier:12259285] PRO:Q9BSB4 [DatabaseIdentifier:12151425] PDB:5XV1 [DatabaseIdentifier:12151428] PDB:5XV3 [DatabaseIdentifier:12151427] PDB:5XV4 [DatabaseIdentifier:12151429] PDB:5XV6 [DatabaseIdentifier:12151424] PDB:5C50 [DatabaseIdentifier:12151430] PDB:5XUY [DatabaseIdentifier:12151431] PDB:8DO8 [DatabaseIdentifier:12151426] PDB:4WZG [DatabaseIdentifier:12120914] OpenTargets:ENSG00000123395 [DatabaseIdentifier:11836440] HPA:ENSG00000123395-ATG101 [DatabaseIdentifier:11783330] GeneCards:ATG101 [DatabaseIdentifier:11742467] ENSEMBL:ENST00000336854 [DatabaseIdentifier:11619768] ENSEMBL:ENSP00000338990 [DatabaseIdentifier:11506562] ENSEMBL:ENSG00000123395
databaseName	UniProt
dbId	224123
description	recommendedName: Autophagy-related protein 101
displayName	UniProt:Q9BSB4 ATG101
geneName	ATG101 C12orf44 PP894
identifier	Q9BSB4
isSequenceChanged	false
keyword	3D-structure Autophagy Cytoplasm Proteomics identification Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	ATG101
otherIdentifier	11726275_a_at 16751464 218214_PM_at 218214_at 3415274 3415275 3415276 3415277 3415278 3415279 3415280 3415281 3415282 3415283 3415284 3415285 3415286 58945_f_at 60673 63295_at 7955606 A_14_P115396 A_23_P116840 GE62263 GO:0000045 GO:0000407 GO:0005515 GO:0005737 GO:0005789 GO:0005829 GO:0006914 GO:0008285 GO:0010508 GO:0019901 GO:0042802 GO:0044877 GO:1990316 HMNXSV003055068 ILMN_1772527 PH_hs_0001025 TC12000415.hg g11345473_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5333634] ATG101 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8948051] ATG101 [endoplasmic reticulum membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12760440] UCSC:Q9BSB4 ATG101 [ReferenceDNASequence:12106670] OMIM:615089 ATG101 [ReferenceDNASequence:12085704] NCBI Gene:60673 ATG101 [ReferenceDNASequence:12001611] Monarch:60673 ATG101 [ReferenceDNASequence:11909832] KEGG:hsa:60673 ATG101 [ReferenceDNASequence:11814946] HGNC:25679 ATG101 [ReferenceDNASequence:11440155] dbSNP Gene:60673 ATG101 [ReferenceDNASequence:11406972] CTD Gene:60673 ATG101 [ReferenceDNASequence:11402649] COSMIC - genes:ATG101 ATG101 [ReferenceDNASequence:11371822] BioGPS Gene:60673 ATG101 [ReferenceDNASequence:ensembl:ENSG00000123395] ENSEMBL:ENSG00000123395 ATG101
referenceTranscript	[ReferenceRNASequence:12623976] RefSeq:XM_054372827.1 ATG101 [ReferenceRNASequence:12623977] RefSeq:NM_001098673.2 ATG101 [ReferenceRNASequence:12623974] RefSeq:XM_024449120.2 ATG101 [ReferenceRNASequence:12623975] RefSeq:NM_021934.4 ATG101
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ATGA1_HUMAN Q9HAE2 Q9HBN1
sequenceLength	218
species	[Species:48887] Homo sapiens
stId	uniprot:Q9BSB4
url	http://purl.uniprot.org/uniprot/Q9BSB4

Referrals

(interactor)	[UndirectedInteraction:11241351] UniProt:O75385 <-> UniProt:Q9BSB4 (IntAct) [UndirectedInteraction:11203689] UniProt:Q9GZQ8 <-> UniProt:Q9BSB4 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-5333634] ATG101 [cytosol] [EntityWithAccessionedSequence:R-HSA-8948051] ATG101 [endoplasmic reticulum membrane]

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