UniProt:Q9BRI3 SLC30A2

chain
  • chain:1-372
checksum 0B004533D3B6D29C
comment
  • FUNCTION Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:17065149, PubMed:21289295, PubMed:22733820, PubMed:25657003, PubMed:25808614, PubMed:30893306). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (PubMed:19496757). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (PubMed:25808614).FUNCTION Electroneutral proton-coupled antiporter mediating the efflux of zinc ions through the plasma membrane.CATALYTIC ACTIVITY Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)SUBUNIT Homodimer (PubMed:22733820). Interacts (via lysosomal targeting motif) with AP3D1; in AP-3-mediated transport to lysosomes (PubMed:25808614). Interacts with TMEM163 (PubMed:36204728).INTERACTION Localization to lysosomes is induced by TNF.SUBCELLULAR LOCATION Phosphorylated at Ser-296. Phosphorylation at Ser-296 prevents localization to lysosomes. Dephosphorylation of Ser-296 which triggers localization to lysosomes, accumulation of zinc into lysosomes and lysosomal-mediated cell death is induced by TNF.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 258037
description
  • recommendedName: fullName evidence="18"Proton-coupled zinc antiporter SLC30A2 alternativeName: fullName evidence="19"Solute carrier family 30 member 2 alternativeName: fullName evidence="13"Zinc transporter 2 shortName evidence="13"ZnT-2
displayName UniProt:Q9BRI3 SLC30A2
geneName
  • SLC30A2
  • ZNT2
identifier Q9BRI3
isSequenceChanged false
keyword
  • Alternative splicing
  • Antiport
  • Cell membrane
  • Cytoplasmic vesicle
  • Disease variant
  • Endosome
  • Ion transport
  • Lysosome
  • Membrane
  • Metal-binding
  • Mitochondrion
  • Mitochondrion inner membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
  • Transport
  • Zinc
  • Zinc transport
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • SLC30A2
otherIdentifier
  • 11741578_a_at
  • 11741579_a_at
  • 16683758
  • 224485_PM_s_at
  • 224485_s_at
  • 230084_PM_at
  • 230084_at
  • 2402518
  • 2402519
  • 2402520
  • 2402521
  • 2402522
  • 2402523
  • 2402524
  • 2402525
  • 2402526
  • 2402527
  • 2402528
  • 2402529
  • 2402530
  • 2402531
  • 2402533
  • 2402535
  • 7780
  • 7913896
  • 90456_at
  • A_23_P319083
  • A_24_P156748
  • GE62950
  • GO:0005385
  • GO:0005515
  • GO:0005737
  • GO:0005739
  • GO:0005743
  • GO:0005764
  • GO:0005765
  • GO:0005768
  • GO:0005770
  • GO:0005886
  • GO:0006811
  • GO:0006812
  • GO:0006829
  • GO:0006882
  • GO:0008324
  • GO:0010008
  • GO:0010043
  • GO:0015297
  • GO:0016020
  • GO:0030658
  • GO:0031410
  • GO:0042589
  • GO:0042802
  • GO:0046872
  • GO:0055085
  • GO:0062111
  • GO:0071577
  • GO:0099503
  • GO:0140826
  • GO:0140882
  • GO:0140914
  • GO:0140915
  • GO:0140916
  • GO:0140917
  • HMNXSV003045001
  • Hs.143545.0.S1_3p_at
  • ILMN_1785549
  • ILMN_2415421
  • PH_hs_0031798
  • TC01002385.hg
  • g13623300_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ZNT2_HUMAN
  • Q71RC8
sequenceLength 372
species [Species:48887] Homo sapiens
stId uniprot:Q9BRI3
url http://purl.uniprot.org/uniprot/Q9BRI3

Referrals

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