UniProt:Q9BQS7 HEPH

chain
  • signal peptide:1-23
  • chain:24-1158
checksum CD032199E2E2868D
comment
  • FUNCTION Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form. Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body (PubMed:22961397, PubMed:37277838). By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body (By similarity).CATALYTIC ACTIVITY 4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2OCOFACTOR Binds 6 Cu cations per monomer.BIOPHYSICOCHEMICAL PROPERTIES kcat is 18 min(-1) for the oxidation of Fe(2+) (at pH 5.0).SUBUNIT Part of a complex composed of SLC40A1/ferroportin, TF/transferrin and HEPH/hephaestin that transfers iron from cells to transferrin.INTERACTION Expressed by intestinal absorptive cells (at protein level) (PubMed:17486601). Also detected in breast, colon, bone trabecular cells and fibroblasts (PubMed:11932491).SIMILARITY Belongs to the multicopper oxidase family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.ONLINE INFORMATION Hephaestin entry
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 148355
description
  • recommendedName: fullName evidence="9"Hephaestin shortName evidence="11"Hp ecNumber evidence="7"1.16.3.1
displayName UniProt:Q9BQS7 HEPH
geneName
  • HEPH
  • KIAA0698
  • UNQ2562/PRO6242
identifier Q9BQS7
isSequenceChanged false
keyword
  • Alternative splicing
  • Calcium
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Ion transport
  • Iron
  • Iron transport
  • Membrane
  • Metal-binding
  • Oxidoreductase
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Signal
  • Sodium
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • HEPH
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • HEPH_HUMAN
  • B1AJX8
  • D3DVT7
  • E9PHN8
  • O75180
  • Q6UW45
  • Q9C058
sequenceLength 1158
species [Species:48887] Homo sapiens
stId uniprot:Q9BQS7
url http://purl.uniprot.org/uniprot/Q9BQS7
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