UniProt:Q9BQ51 PDCD1LG2

chain
  • signal peptide:1-19
  • chain:20-273
checksum 8B7E963C9BA26ED9
comment
  • FUNCTION Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11224527, PubMed:12538684). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production (PubMed:11224527).INTERACTION Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.INDUCTION Up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4/interleukin-4.SIMILARITY Belongs to the immunoglobulin superfamily. BTN/MOG family.
created [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference
databaseName UniProt
dbId 413328
description
  • recommendedName: Programmed cell death 1 ligand 2 shortName: PD-1 ligand 2 shortName: PD-L2 shortName: PDCD1 ligand 2 shortName: Programmed death ligand 2 alternativeName: Butyrophilin B7-DC shortName: B7-DC cdAntigenNameCD273/cdAntigenName
displayName UniProt:Q9BQ51 PDCD1LG2
geneName
  • PDCD1LG2
  • B7DC
  • CD273
  • PDCD1L2
  • PDL2
identifier Q9BQ51
isSequenceChanged false
keyword
  • 3D-structure
  • Adaptive immunity
  • Alternative splicing
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Immunity
  • Immunoglobulin domain
  • Membrane
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • PDCD1LG2
otherIdentifier
  • 11736811_a_at
  • 11736812_at
  • 11736813_at
  • 11751859_a_at
  • 17083370
  • 220049_PM_s_at
  • 220049_s_at
  • 224399_PM_at
  • 224399_at
  • 3161114
  • 3161115
  • 3161120
  • 3161126
  • 3161135
  • 3161136
  • 3161137
  • 3161140
  • 3161142
  • 47403_at
  • 80380
  • 8154245
  • A_14_P111176
  • A_23_P94412
  • A_33_P3213707
  • GE55942
  • GE80011
  • GO:0002250
  • GO:0002376
  • GO:0005515
  • GO:0005576
  • GO:0005886
  • GO:0006955
  • GO:0007166
  • GO:0009897
  • GO:0012505
  • GO:0016020
  • GO:0031295
  • GO:0032689
  • GO:0032693
  • GO:0042102
  • GO:0042130
  • GO:0046007
  • GO:0071222
  • HMNXSV003053187
  • ILMN_2159272
  • PH_hs_0003930
  • TC09000038.hg
  • g13376849_3p_s_at
  • g13569409_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PD1L2_HUMAN
  • Q14CN8
  • Q5T7Z6
  • Q6JXL8
  • Q6JXL9
sequenceLength 273
species [Species:48887] Homo sapiens
stId uniprot:Q9BQ51
url http://purl.uniprot.org/uniprot/Q9BQ51
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