UniProt:Q99P21 Mutyh

chain
  • chain:1-515
checksum 10DC39CC3A01AE5B
comment
  • FUNCTION Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.CATALYTIC ACTIVITY Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.COFACTOR Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.SUBCELLULAR LOCATION Expressed in heart, lung, liver, intestine, brain and thymus.SIMILARITY Belongs to the Nth/MutY family.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 150751
description
  • recommendedName: Adenine DNA glycosylase ecNumber evidence="5"3.2.2.31 alternativeName: MutY homolog shortName: mMYH
displayName UniProt:Q99P21 Mutyh
geneName
  • Mutyh
  • Myh
identifier Q99P21
isSequenceChanged false
keyword
  • 3D-structure
  • 4Fe-4S
  • DNA damage
  • DNA repair
  • Glycosidase
  • Hydrolase
  • Iron
  • Iron-sulfur
  • Metal-binding
  • Mitochondrion
  • Nucleus
  • Reference proteome
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • Mutyh
otherIdentifier
  • 10507362
  • 113540_at
  • 1422816_a_at
  • 17417530
  • 4369991
  • 4465204
  • 4512356
  • 4535527
  • 4536859
  • 4609759
  • 4631547
  • 4671077
  • 4702908
  • 4726878
  • 4775190
  • 4792327
  • 4920549
  • 4981008
  • 5000404
  • 5085494
  • 5133482
  • 5143839
  • 5154818
  • 5184988
  • 5188627
  • 5223615
  • 5273432
  • 5289836
  • 5318858
  • 5329355
  • 5334958
  • 5446406
  • 5500161
  • 5578417
  • 70603
  • 96558_at
  • A_52_P165831
  • A_52_P238785
  • A_55_P1978122
  • A_65_P12908
  • GE126837
  • GO:0000701
  • GO:0003677
  • GO:0003824
  • GO:0005634
  • GO:0005654
  • GO:0005739
  • GO:0006281
  • GO:0006284
  • GO:0006298
  • GO:0006950
  • GO:0006974
  • GO:0016787
  • GO:0016798
  • GO:0019104
  • GO:0032357
  • GO:0032407
  • GO:0034039
  • GO:0035485
  • GO:0046872
  • GO:0051536
  • GO:0051539
  • GO:0060546
  • GO:0140097
  • ILMN_1219741
  • ILMN_2590061
  • ILMN_2920924
  • aa409965_at
  • mMC004866
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MUTYH_MOUSE
  • A2AGE3
sequenceLength 515
species [Species:48892] Mus musculus
stId uniprot:Q99P21
url http://purl.uniprot.org/uniprot/Q99P21
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