UniProt:Q99J83 Atg5

chain
  • chain:1-275
checksum F3FCE652D627B694
comment
  • FUNCTION Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. As part of the ATG8 conjugation system with ATG12 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (PubMed:38227290).FUNCTION May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD (By similarity).FUNCTION (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection.SUBUNIT Forms a conjugate with ATG12 (PubMed:11266458, PubMed:12665549, PubMed:12890687, PubMed:18768753, PubMed:19417210). Part of the minor complex composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa); this complex interacts with ATG3 leading to disruption of ATG7 interaction and promotion of ATG8-like proteins lipidation (PubMed:12665549). Forms an 800-kDa complex composed of ATG12-ATG5 and ATG16L2 (PubMed:22082872). The ATG12-ATG5 conjugate interacts with RAB33A; this interaction is bridged by ATG16L1 and promotes ATG12-ATG5-ATG16L1 complex recruitment to phagophores (By similarity). Interacts with TECPR1; the interaction is direct and does not take place when ATG16L1 is associated with the ATG5-ATG12 conjugate (By similarity). Interacts with DHX58/RIG-1, IFIH1/MDA5 and MAVS/IPS-1 in monomeric form as well as in ATG12-ATG5 conjugate form. The interaction with MAVS is further enhanced upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Interacts with ATG3 (By similarity). Interacts with ATG7 and ATG10 (PubMed:12482611). Interacts with FADD (By similarity). Interacts with Bassoon/BSN; this interaction is important for the regulation of presynaptic autophagy. Interacts with ATG16L2 (PubMed:22082872).INTERACTION The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. Under starved conditions, the ATG12-ATG5-ATG16L1 complex is translocated to phagophores driven by RAB33B (By similarity).TISSUE SPECIFICITY Ubiquitous.PTM Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.PTM Acetylated by EP300.SIMILARITY Belongs to the ATG5 family.
crossReference
databaseName UniProt
dbId 85147
description
  • recommendedName: fullName evidence="20"Autophagy protein 5 alternativeName: APG5-like
displayName UniProt:Q99J83 Atg5
geneName
  • Atg5
  • Apg5l
identifier Q99J83
isSequenceChanged false
keyword
  • Acetylation
  • Apoptosis
  • Autophagy
  • Cytoplasm
  • Immunity
  • Isopeptide bond
  • Membrane
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • Atg5
otherIdentifier
  • 10338268
  • 10338401
  • 10338565
  • 10338984
  • 10339127
  • 10339204
  • 10339247
  • 10339889
  • 10340175
  • 10340291
  • 10340552
  • 10340657
  • 10341553
  • 10341676
  • 10342184
  • 10342257
  • 10342288
  • 10342567
  • 10343205
  • 10343908
  • 10344127
  • 10344514
  • 10362922
  • 11793
  • 1415684_at
  • 1418235_at
  • 1418236_s_at
  • 17202035
  • 17233061
  • 4337315
  • 4350258
  • 4453559
  • 4470957
  • 4471870
  • 4479694
  • 4483272
  • 4492605
  • 4521059
  • 4579422
  • 4602276
  • 4678555
  • 4713555
  • 4741350
  • 4755258
  • 4799747
  • 4911508
  • 5011128
  • 5045515
  • 5292021
  • 5343189
  • 5375266
  • 5402713
  • 5515094
  • 5550623
  • 5598983
  • 94225_at
  • A_52_P254981
  • A_55_P2015113
  • GE41996
  • GO:0000045
  • GO:0000423
  • GO:0001974
  • GO:0002376
  • GO:0002718
  • GO:0003013
  • GO:0003824
  • GO:0005515
  • GO:0005737
  • GO:0005773
  • GO:0005776
  • GO:0005829
  • GO:0005930
  • GO:0006325
  • GO:0006914
  • GO:0006915
  • GO:0006995
  • GO:0007018
  • GO:0009267
  • GO:0009410
  • GO:0009620
  • GO:0010040
  • GO:0010508
  • GO:0010659
  • GO:0010667
  • GO:0016020
  • GO:0016236
  • GO:0016567
  • GO:0016740
  • GO:0019776
  • GO:0019883
  • GO:0030163
  • GO:0030424
  • GO:0031397
  • GO:0032480
  • GO:0032991
  • GO:0034045
  • GO:0034274
  • GO:0034727
  • GO:0035973
  • GO:0039689
  • GO:0042311
  • GO:0043066
  • GO:0043687
  • GO:0044233
  • GO:0045060
  • GO:0045087
  • GO:0045202
  • GO:0045824
  • GO:0048840
  • GO:0048856
  • GO:0050687
  • GO:0050765
  • GO:0051279
  • GO:0051607
  • GO:0051649
  • GO:0055015
  • GO:0060047
  • GO:0061684
  • GO:0061908
  • GO:0062029
  • GO:0070254
  • GO:0070257
  • GO:0071500
  • GO:0098542
  • GO:0098685
  • GO:0098794
  • GO:0098930
  • GO:0098978
  • GO:0099072
  • GO:0099170
  • GO:0140096
  • GO:1901096
  • GO:1902017
  • GO:1902115
  • GO:1902617
  • GO:1904093
  • GO:1904973
  • GO:1990234
  • GO:2000377
  • ILMN_1217612
  • ILMN_1232319
  • ILMN_2627025
  • ILMN_2998135
  • ILMN_2998139
  • mMC010196
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ATG5_MOUSE
sequenceLength 275
species [Species:48892] Mus musculus
stId uniprot:Q99J83
url http://purl.uniprot.org/uniprot/Q99J83
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