Reactome | UniProt:Q99943 AGPAT1

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UniProt:Q99943 AGPAT1 Show undefined attributes

chain	signal peptide:1-26 chain:27-283
checksum	71F3207259747C68
comment	FUNCTION Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.CATALYTIC ACTIVITY a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY heptadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY pentadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-eicosanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-tetradecanoyl-sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY (6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoABIOPHYSICOCHEMICAL PROPERTIES Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.INTERACTION Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas. Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate, ovary, intestine, colon, leukocyte and liver.DOMAIN The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.SIMILARITY Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.SEQUENCE CAUTION Truncated N-terminus.
crossReference	[DatabaseIdentifier:11529542] ENSEMBL:ENSP00000382721 [DatabaseIdentifier:12307152] RefSeq:NP_006402.1 [DatabaseIdentifier:12307154] RefSeq:NP_001358367.1 [DatabaseIdentifier:12307155] RefSeq:NP_116130.2 [DatabaseIdentifier:12307153] RefSeq:NP_001358368.1 [DatabaseIdentifier:12280492] Pharos - Targets:Q99943 [DatabaseIdentifier:12237440] PRO:Q99943 [DatabaseIdentifier:12120154] OpenTargets:ENSG00000204310 [DatabaseIdentifier:11835694] HPA:ENSG00000204310-AGPAT1 [DatabaseIdentifier:11830030] HMDB Protein:HMDBP01581 [DatabaseIdentifier:11782577] GeneCards:AGPAT1 [DatabaseIdentifier:11652240] ENSEMBL:ENST00000439774 [DatabaseIdentifier:11652234] ENSEMBL:ENST00000395497 [DatabaseIdentifier:11652263] ENSEMBL:ENST00000456421 [DatabaseIdentifier:11652244] ENSEMBL:ENST00000375104 [DatabaseIdentifier:11652222] ENSEMBL:ENST00000414520 [DatabaseIdentifier:11652230] ENSEMBL:ENST00000395499 [DatabaseIdentifier:11652246] ENSEMBL:ENST00000454929 [DatabaseIdentifier:11652237] ENSEMBL:ENST00000436149 [DatabaseIdentifier:11652231] ENSEMBL:ENST00000457923 [DatabaseIdentifier:11652224] ENSEMBL:ENST00000424030 [DatabaseIdentifier:11652232] ENSEMBL:ENST00000395496 [DatabaseIdentifier:11652249] ENSEMBL:ENST00000446463 [DatabaseIdentifier:11652225] ENSEMBL:ENST00000399825 [DatabaseIdentifier:11652245] ENSEMBL:ENST00000446323 [DatabaseIdentifier:11652255] ENSEMBL:ENST00000455898 [DatabaseIdentifier:11652251] ENSEMBL:ENST00000425572 [DatabaseIdentifier:11652243] ENSEMBL:ENST00000399830 [DatabaseIdentifier:11652228] ENSEMBL:ENST00000456679 [DatabaseIdentifier:11652227] ENSEMBL:ENST00000399827 [DatabaseIdentifier:11652260] ENSEMBL:ENST00000452427 [DatabaseIdentifier:11652261] ENSEMBL:ENST00000415173 [DatabaseIdentifier:11652248] ENSEMBL:ENST00000399833 [DatabaseIdentifier:11652242] ENSEMBL:ENST00000444369 [DatabaseIdentifier:11652254] ENSEMBL:ENST00000427763 [DatabaseIdentifier:11652252] ENSEMBL:ENST00000375107 [DatabaseIdentifier:11652239] ENSEMBL:ENST00000417388 [DatabaseIdentifier:11652247] ENSEMBL:ENST00000414933 [DatabaseIdentifier:11652235] ENSEMBL:ENST00000433896 [DatabaseIdentifier:11652223] ENSEMBL:ENST00000383294 [DatabaseIdentifier:11652258] ENSEMBL:ENST00000425204 [DatabaseIdentifier:11652256] ENSEMBL:ENST00000448196 [DatabaseIdentifier:11652241] ENSEMBL:ENST00000440840 [DatabaseIdentifier:11652259] ENSEMBL:ENST00000451833 [DatabaseIdentifier:11652253] ENSEMBL:ENST00000430777 [DatabaseIdentifier:11652236] ENSEMBL:ENST00000433376 [DatabaseIdentifier:11652238] ENSEMBL:ENST00000452393 [DatabaseIdentifier:11652233] ENSEMBL:ENST00000430226 [DatabaseIdentifier:11652226] ENSEMBL:ENST00000336984 [DatabaseIdentifier:11652250] ENSEMBL:ENST00000449776 [DatabaseIdentifier:11652229] ENSEMBL:ENST00000399829 [DatabaseIdentifier:11652262] ENSEMBL:ENST00000416363 [DatabaseIdentifier:11652257] ENSEMBL:ENST00000434614 [DatabaseIdentifier:11529547] ENSEMBL:ENSP00000337463 [DatabaseIdentifier:11529541] ENSEMBL:ENSP00000389516 [DatabaseIdentifier:11529554] ENSEMBL:ENSP00000412805 [DatabaseIdentifier:11529544] ENSEMBL:ENSP00000392083 [DatabaseIdentifier:11529537] ENSEMBL:ENSP00000378877 [DatabaseIdentifier:11529531] ENSEMBL:ENSP00000390988 [DatabaseIdentifier:11529532] ENSEMBL:ENSP00000407189 [DatabaseIdentifier:11529528] ENSEMBL:ENSP00000401287 [DatabaseIdentifier:11529564] ENSEMBL:ENSP00000415015 [DatabaseIdentifier:11529562] ENSEMBL:ENSP00000372782 [DatabaseIdentifier:11529561] ENSEMBL:ENSP00000412304 [DatabaseIdentifier:11443610] ENSEMBL:ENSG00000235758 [DatabaseIdentifier:11443607] ENSEMBL:ENSG00000236873 [DatabaseIdentifier:11443609] ENSEMBL:ENSG00000206324 [DatabaseIdentifier:11443611] ENSEMBL:ENSG00000204310 [DatabaseIdentifier:11443606] ENSEMBL:ENSG00000226467 [DatabaseIdentifier:11443612] ENSEMBL:ENSG00000228892 [DatabaseIdentifier:11443608] ENSEMBL:ENSG00000227642 [DatabaseIdentifier:11529557] ENSEMBL:ENSP00000388253 [DatabaseIdentifier:11529555] ENSEMBL:ENSP00000394919 [DatabaseIdentifier:11529545] ENSEMBL:ENSP00000387738 [DatabaseIdentifier:11529536] ENSEMBL:ENSP00000382728 [DatabaseIdentifier:11529540] ENSEMBL:ENSP00000410831 [DatabaseIdentifier:11529553] ENSEMBL:ENSP00000395863 [DatabaseIdentifier:11529534] ENSEMBL:ENSP00000406582 [DatabaseIdentifier:11529524] ENSEMBL:ENSP00000387810 [DatabaseIdentifier:11529546] ENSEMBL:ENSP00000382725 [DatabaseIdentifier:11529559] ENSEMBL:ENSP00000398016 [DatabaseIdentifier:11529523] ENSEMBL:ENSP00000392820 [DatabaseIdentifier:11529558] ENSEMBL:ENSP00000408032 [DatabaseIdentifier:11529525] ENSEMBL:ENSP00000406615 [DatabaseIdentifier:11529539] ENSEMBL:ENSP00000378874 [DatabaseIdentifier:11529563] ENSEMBL:ENSP00000388815 [DatabaseIdentifier:11529529] ENSEMBL:ENSP00000405565 [DatabaseIdentifier:11529552] ENSEMBL:ENSP00000404106 [DatabaseIdentifier:11529560] ENSEMBL:ENSP00000397765 [DatabaseIdentifier:11529549] ENSEMBL:ENSP00000364248 [DatabaseIdentifier:11529550] ENSEMBL:ENSP00000388870 [DatabaseIdentifier:11529551] ENSEMBL:ENSP00000401410 [DatabaseIdentifier:11529538] ENSEMBL:ENSP00000388090 [DatabaseIdentifier:11529533] ENSEMBL:ENSP00000382726 [DatabaseIdentifier:11529526] ENSEMBL:ENSP00000406614 [DatabaseIdentifier:11529530] ENSEMBL:ENSP00000395613 [DatabaseIdentifier:11529535] ENSEMBL:ENSP00000378875 [DatabaseIdentifier:11529548] ENSEMBL:ENSP00000364245 [DatabaseIdentifier:11529527] ENSEMBL:ENSP00000405864 [DatabaseIdentifier:11529543] ENSEMBL:ENSP00000382723 [DatabaseIdentifier:11529556] ENSEMBL:ENSP00000408842
databaseName	UniProt
dbId	61804
description	recommendedName: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha ecNumber evidence="3 4"2.3.1.51 alternativeName: 1-acylglycerol-3-phosphate O-acyltransferase 1 shortName: 1-AGP acyltransferase 1 shortName: 1-AGPAT 1 alternativeName: fullName evidence="5"Lysophosphatidic acid acyltransferase alpha shortName: LPAAT-alpha alternativeName: Protein G15
displayName	UniProt:Q99943 AGPAT1
geneName	AGPAT1 G15
identifier	Q99943
isSequenceChanged	false
keyword	Acyltransferase Endoplasmic reticulum Lipid biosynthesis Lipid metabolism Membrane Phospholipid biosynthesis Phospholipid metabolism Proteomics identification Reference proteome Signal Transferase Transmembrane Transmembrane helix
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	AGPAT1
otherIdentifier	10554 11730933_a_at 11750187_a_at 11750188_x_at 11751668_a_at 17017748 17026979 17029579 17034570 17037071 17039779 17042275 215535_3p_s_at 215535_PM_s_at 215535_s_at 2949802 2949803 2949804 2949805 2949806 2949807 2949808 2949809 2949810 2949811 2949812 2949813 2949814 2949815 2949816 2949818 2949819 2949820 2949821 2949822 2949823 2949824 32836_3p_at 32836_PM_at 32836_at 4890567C_3p_s_at 8125328 8178762 8179958 A_23_P258093 GE80479 GO:0001819 GO:0001961 GO:0003841 GO:0005515 GO:0005783 GO:0005789 GO:0006629 GO:0006644 GO:0006654 GO:0008654 GO:0016020 GO:0016024 GO:0016740 GO:0016746 HMNXSV003029811 HMNXSV003032315 Hs.240534.2.S1_3p_s_at ILMN_1679520 ILMN_1697790 ILMN_1779109 PH_hs_0024790 TC06001561.hg TC6_apd_hap1000094.hg TC6_cox_hap2000186.hg TC6_mann_hap4000151.hg TC6_mcf_hap5000161.hg TC6_qbl_hap6000175.hg TC6_ssto_hap7000155.hg U56417_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-61803] AGPAT1 [endoplasmic reticulum membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000204310] ENSEMBL:ENSG00000204310 AGPAT1 [ReferenceDNASequence:12721187] UCSC:Q99943 AGPAT1 [ReferenceDNASequence:12105983] OMIM:603099 AGPAT1 [ReferenceDNASequence:12023106] NCBI Gene:10554 AGPAT1 [ReferenceDNASequence:11939013] Monarch:10554 AGPAT1 [ReferenceDNASequence:11852983] KEGG:hsa:10554 AGPAT1 [ReferenceDNASequence:11814185] HGNC:324 AGPAT1 [ReferenceDNASequence:11309224] BioGPS Gene:10554 AGPAT1 [ReferenceDNASequence:11397197] COSMIC - genes:AGPAT1 AGPAT1 [ReferenceDNASequence:11405991] CTD Gene:10554 AGPAT1 [ReferenceDNASequence:11433844] dbSNP Gene:10554 AGPAT1
referenceTranscript	[ReferenceRNASequence:12489290] RefSeq:NM_006411.4 AGPAT1 [ReferenceRNASequence:12489292] RefSeq:NM_001371439.1 AGPAT1 [ReferenceRNASequence:12489293] RefSeq:NM_001371438.1 AGPAT1 [ReferenceRNASequence:12489291] RefSeq:NM_032741.4 AGPAT1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PLCA_HUMAN A2BFI5 Q5BL03
sequenceLength	283
species	[Species:48887] Homo sapiens
stId	uniprot:Q99943
url	http://purl.uniprot.org/uniprot/Q99943

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-61803] AGPAT1 [endoplasmic reticulum membrane]
(interactor)	[UndirectedInteraction:11204525] UniProt:Q8TDQ0 <-> UniProt:Q99943 (IntAct) [UndirectedInteraction:11304485] UniProt:Q99943 <-> UniProt:O75792 (IntAct) [UndirectedInteraction:11304487] UniProt:Q99943 <-> UniProt:P50222 (IntAct) [UndirectedInteraction:11304489] UniProt:Q99943 <-> UniProt:O60896 (IntAct)

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