UniProt:Q99650 OSMR

chain
  • signal peptide:1-27
  • chain:28-979
checksum 179852CA3D90D9EF
comment
  • FUNCTION Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.SUBUNIT Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.INTERACTION Expressed in keratinocytes (at protein level) (PubMed:21261663). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells (PubMed:8999038).INDUCTION Activated by oncostatin-M (PubMed:8999038). Up-regulated by IFNG/IFN-gamma (PubMed:15184896, PubMed:21261663). Up-regulated by bacterial lipopolysaccharides (LPS) (PubMed:15184896). Up-regulated by triacylated lipoprotein (Pam3Cys) (PubMed:21261663).DOMAIN The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.DOMAIN The box 1 motif is required for JAK interaction and/or activation.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the type I cytokine receptor family. Type 2 subfamily.SEQUENCE CAUTION Truncated C-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 241230
description
  • recommendedName: Oncostatin-M-specific receptor subunit beta alternativeName: Interleukin-31 receptor subunit beta shortName: IL-31 receptor subunit beta shortName: IL-31R subunit beta shortName: IL-31R-beta shortName: IL-31RB
displayName UniProt:Q99650 OSMR
geneName
  • OSMR
  • OSMRB
identifier Q99650
isSequenceChanged false
keyword
  • Alternative splicing
  • Amyloidosis
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • OSMR
otherIdentifier
  • 11733184_a_at
  • 11733185_at
  • 11733186_at
  • 11752556_a_at
  • 11759644_at
  • 1554008_PM_at
  • 1554008_at
  • 1648_at
  • 16984244
  • 205729_PM_at
  • 205729_at
  • 226621_PM_at
  • 226621_at
  • 2807374
  • 2807375
  • 2807376
  • 2807377
  • 2807382
  • 2807383
  • 2807389
  • 2807390
  • 2807391
  • 2807394
  • 2807396
  • 2807397
  • 2807398
  • 2807399
  • 2807401
  • 2807402
  • 2807403
  • 2807404
  • 2807408
  • 2807409
  • 2807410
  • 2807411
  • 2807412
  • 2807414
  • 2807415
  • 2807417
  • 2807418
  • 2807422
  • 2807423
  • 2807425
  • 2807426
  • 2807427
  • 2807428
  • 2807429
  • 2807430
  • 2807431
  • 2807436
  • 2807437
  • 39277_at
  • 55640_at
  • 8105040
  • 84268_at
  • 9180
  • A_14_P108529
  • A_14_P109264
  • A_14_P201364
  • A_21_P0000073
  • A_23_P156289
  • A_24_P145134
  • A_24_P388860
  • GE62862
  • GO:0002675
  • GO:0004896
  • GO:0004924
  • GO:0005127
  • GO:0005515
  • GO:0005886
  • GO:0005900
  • GO:0008284
  • GO:0009897
  • GO:0016020
  • GO:0016324
  • GO:0019221
  • GO:0019838
  • GO:0019955
  • GO:0034097
  • GO:0038165
  • GO:0043235
  • HMNXSV003013386
  • HMNXSV003041232
  • HMNXSV003056290
  • Hs.75431.3.S1_3p_at
  • Hs2.238648.2.S1_3p_at
  • ILMN_2205999
  • PH_hs_0012877
  • TC05000179.hg
  • U60805_at
  • g4557039_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • OSMR_HUMAN
  • Q6P4E8
  • Q96QJ6
sequenceLength 979
species [Species:48887] Homo sapiens
stId uniprot:Q99650
url http://purl.uniprot.org/uniprot/Q99650
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