Reactome | UniProt:Q99633 PRPF18

chain	chain:1-342
checksum	269D79E1E733CF6D
comment	FUNCTION Participates in the second step of pre-mRNA splicing.SUBUNIT Heterodimer with PPIH. Interacts with PRPF4 and with the spliceosome. Part of a complex containing U4/U6 snRNPs.INTERACTION Colocalizes with spliceosomal snRNPs.ALTERNATIVE PRODUCTS Belongs to the PRP18 family.
crossReference	[DatabaseIdentifier:11445084] ENSEMBL:ENSG00000165630 [DatabaseIdentifier:12310440] RefSeq:XP_047281886.1 [DatabaseIdentifier:12310462] RefSeq:XP_047281898.1 [DatabaseIdentifier:12310461] RefSeq:XP_047281895.1 [DatabaseIdentifier:12310465] RefSeq:XP_047281879.1 [DatabaseIdentifier:12310426] RefSeq:XP_047281915.1 [DatabaseIdentifier:12310456] RefSeq:XP_047281894.1 [DatabaseIdentifier:12310455] RefSeq:XP_047281912.1 [DatabaseIdentifier:12310459] RefSeq:XP_047281910.1 [DatabaseIdentifier:12310438] RefSeq:XP_047281884.1 [DatabaseIdentifier:12310453] RefSeq:XP_047281913.1 [DatabaseIdentifier:12310430] RefSeq:XP_047281920.1 [DatabaseIdentifier:12310437] RefSeq:XP_047281883.1 [DatabaseIdentifier:12310458] RefSeq:XP_047281893.1 [DatabaseIdentifier:12310450] RefSeq:XP_047281907.1 [DatabaseIdentifier:12310442] RefSeq:XP_047281888.1 [DatabaseIdentifier:12310444] RefSeq:XP_047281906.1 [DatabaseIdentifier:12310443] RefSeq:XP_047281889.1 [DatabaseIdentifier:12310439] RefSeq:XP_047281885.1 [DatabaseIdentifier:12310447] RefSeq:XP_047281903.1 [DatabaseIdentifier:12310464] RefSeq:XP_047281899.1 [DatabaseIdentifier:12310431] RefSeq:XP_047281880.1 [DatabaseIdentifier:12310432] RefSeq:XP_047281902.1 [DatabaseIdentifier:12310446] RefSeq:XP_047281904.1 [DatabaseIdentifier:12310448] RefSeq:XP_047281909.1 [DatabaseIdentifier:12310428] RefSeq:XP_047281919.1 [DatabaseIdentifier:12310454] RefSeq:XP_047281891.1 [DatabaseIdentifier:12310435] RefSeq:XP_047281882.1 [DatabaseIdentifier:12310429] RefSeq:XP_047281918.1 [DatabaseIdentifier:12310434] RefSeq:XP_047281901.1 [DatabaseIdentifier:12310427] RefSeq:XP_047281914.1 [DatabaseIdentifier:12310425] RefSeq:XP_047281916.1 [DatabaseIdentifier:12310449] RefSeq:XP_047281908.1 [DatabaseIdentifier:12310457] RefSeq:XP_047281911.1 [DatabaseIdentifier:12310436] RefSeq:XP_047281900.1 [DatabaseIdentifier:12310441] RefSeq:XP_047281887.1 [DatabaseIdentifier:12310463] RefSeq:XP_047281897.1 [DatabaseIdentifier:12310433] RefSeq:XP_047281881.1 [DatabaseIdentifier:12310424] RefSeq:XP_047281917.1 [DatabaseIdentifier:12310445] RefSeq:XP_047281905.1 [DatabaseIdentifier:12310423] RefSeq:NP_003666.1 [DatabaseIdentifier:12310452] RefSeq:XP_047281892.1 [DatabaseIdentifier:12310460] RefSeq:XP_047281896.1 [DatabaseIdentifier:12310451] RefSeq:XP_047281890.1 [DatabaseIdentifier:12281704] Pharos - Targets:Q99633 [DatabaseIdentifier:12239194] PRO:Q99633 [DatabaseIdentifier:12153874] PDB:2DK4 [DatabaseIdentifier:12121376] OpenTargets:ENSG00000165630 [DatabaseIdentifier:11836892] HPA:ENSG00000165630-PRPF18 [DatabaseIdentifier:11783787] GeneCards:PRPF18 [DatabaseIdentifier:11654455] ENSEMBL:ENST00000378572 [DatabaseIdentifier:11531756] ENSEMBL:ENSP00000367835
databaseName	UniProt
dbId	98823
description	recommendedName: Pre-mRNA-splicing factor 18 alternativeName: PRP18 homolog shortName: hPRP18
displayName	UniProt:Q99633 PRPF18
geneName	PRPF18 HPRP18
identifier	Q99633
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing mRNA processing mRNA splicing Nucleus Proteomics identification Reference proteome Spliceosome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	PRPF18
otherIdentifier	11731492_at 16702608 221547_PM_at 221547_at 223685_PM_s_at 223685_s_at 2771401 3235937 3235938 3235939 3235944 3235946 3235949 3235952 3235954 3235955 3235956 3235957 3235958 3235959 3235960 3235965 3235966 3235967 3235968 3235969 3235970 3235971 3235974 3235975 3235982 3235983 3235984 3235985 3235986 3235987 3235988 3235989 3235990 3235991 3235992 3235993 3235994 3235997 3236000 3236010 3236012 3236014 40269_at 51840_at 7926283 8559 A_14_P120666 A_14_P128466 A_23_P127195 A_23_P418046 GE56701 GE62150 GO:0000350 GO:0005515 GO:0005634 GO:0005654 GO:0005681 GO:0005682 GO:0006397 GO:0008380 GO:0016071 GO:0016607 GO:0046540 GO:0071021 HMNXSV003005161 HMNXSV003010915 HMNXSV003017933 HMNXSV003031061 HMNXSV003031370 ILMN_1807243 PH_hs_0023651 U51990_at g12653992_3p_at g12803490_3p_s_at p25742
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5688093] PRPF18 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000165630] ENSEMBL:ENSG00000165630 PRPF18 [ReferenceDNASequence:12722111] UCSC:Q99633 PRPF18 [ReferenceDNASequence:12107089] OMIM:604993 PRPF18 [ReferenceDNASequence:12024657] NCBI Gene:8559 PRPF18 [ReferenceDNASequence:11940564] Monarch:8559 PRPF18 [ReferenceDNASequence:11854462] KEGG:hsa:8559 PRPF18 [ReferenceDNASequence:11815408] HGNC:17351 PRPF18 [ReferenceDNASequence:11434016] dbSNP Gene:8559 PRPF18 [ReferenceDNASequence:11407527] CTD Gene:8559 PRPF18 [ReferenceDNASequence:11397343] COSMIC - genes:PRPF18 PRPF18 [ReferenceDNASequence:11310775] BioGPS Gene:8559 PRPF18
referenceTranscript	[ReferenceRNASequence:12492508] RefSeq:XM_047425936.1 PRPF18 [ReferenceRNASequence:12492540] RefSeq:XM_047425944.1 PRPF18 [ReferenceRNASequence:12492526] RefSeq:XM_047425927.1 PRPF18 [ReferenceRNASequence:12492546] RefSeq:XM_047425963.1 PRPF18 [ReferenceRNASequence:12492529] RefSeq:XM_047425924.1 PRPF18 [ReferenceRNASequence:12492523] RefSeq:XM_047425951.1 PRPF18 [ReferenceRNASequence:12492519] RefSeq:XM_047425934.1 PRPF18 [ReferenceRNASequence:12492543] RefSeq:XM_047425961.1 PRPF18 [ReferenceRNASequence:12492521] RefSeq:XM_047425950.1 PRPF18 [ReferenceRNASequence:12492538] RefSeq:XM_047425943.1 PRPF18 [ReferenceRNASequence:12492534] RefSeq:XM_047425928.1 PRPF18 [ReferenceRNASequence:12492541] RefSeq:XM_047425945.1 PRPF18 [ReferenceRNASequence:12492545] RefSeq:XM_047425940.1 PRPF18 [ReferenceRNASequence:12492542] RefSeq:XM_047425923.1 PRPF18 [ReferenceRNASequence:12492547] RefSeq:XM_047425941.1 PRPF18 [ReferenceRNASequence:12492524] RefSeq:XM_047425931.1 PRPF18 [ReferenceRNASequence:12492536] RefSeq:NM_003675.4 PRPF18 [ReferenceRNASequence:12492528] RefSeq:XM_047425925.1 PRPF18 [ReferenceRNASequence:12492522] RefSeq:XM_047425932.1 PRPF18 [ReferenceRNASequence:12492532] RefSeq:XM_047425929.1 PRPF18 [ReferenceRNASequence:12492533] RefSeq:XM_047425948.1 PRPF18 [ReferenceRNASequence:12492527] RefSeq:XM_047425926.1 PRPF18 [ReferenceRNASequence:12492518] RefSeq:XM_047425956.1 PRPF18 [ReferenceRNASequence:12492537] RefSeq:XM_047425942.1 PRPF18 [ReferenceRNASequence:12492535] RefSeq:XM_047425949.1 PRPF18 [ReferenceRNASequence:12492525] RefSeq:XM_047425952.1 PRPF18 [ReferenceRNASequence:12492520] RefSeq:XM_047425933.1 PRPF18 [ReferenceRNASequence:12492539] RefSeq:XM_047425964.1 PRPF18 [ReferenceRNASequence:12492548] RefSeq:XM_047425962.1 PRPF18 [ReferenceRNASequence:12492531] RefSeq:XM_047425947.1 PRPF18 [ReferenceRNASequence:12492544] RefSeq:XM_047425960.1 PRPF18 [ReferenceRNASequence:12492530] RefSeq:XM_047425946.1 PRPF18 [ReferenceRNASequence:12492510] RefSeq:XM_047425957.1 PRPF18 [ReferenceRNASequence:12492514] RefSeq:XM_047425930.1 PRPF18 [ReferenceRNASequence:12492512] RefSeq:XM_047425959.1 PRPF18 [ReferenceRNASequence:12492511] RefSeq:XM_047425958.1 PRPF18 [ReferenceRNASequence:12492517] RefSeq:XM_047425955.1 PRPF18 [ReferenceRNASequence:12492515] RefSeq:XM_047425953.1 PRPF18 [ReferenceRNASequence:12492506] RefSeq:XM_047425938.1 PRPF18 [ReferenceRNASequence:12492507] RefSeq:XM_047425937.1 PRPF18 [ReferenceRNASequence:12492516] RefSeq:XM_047425954.1 PRPF18 [ReferenceRNASequence:12492513] RefSeq:XM_047425939.1 PRPF18 [ReferenceRNASequence:12492509] RefSeq:XM_047425935.1 PRPF18
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PRP18_HUMAN Q5T9P9 Q9BUI9
sequenceLength	342
species	[Species:48887] Homo sapiens
stId	uniprot:Q99633
url	http://purl.uniprot.org/uniprot/Q99633

UniProt:Q99633 PRPF18 Show undefined attributes

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