Reactome | UniProt:Q99627 COPS8

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UniProt:Q99627 COPS8 Show undefined attributes

chain	initiator methionine:1 chain:2-209
checksum	203E236D8E304A8A
comment	FUNCTION Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.SUBUNIT Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B) (PubMed:18850735).INTERACTION Belongs to the CSN8 family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12310561] RefSeq:NP_937832.1 [DatabaseIdentifier:12310562] RefSeq:NP_006701.1 [DatabaseIdentifier:12281739] Pharos - Targets:Q99627 [DatabaseIdentifier:12239233] PRO:Q99627 [DatabaseIdentifier:12143946] PDB:6R7N [DatabaseIdentifier:12145765] PDB:4WSN [DatabaseIdentifier:12145766] PDB:4D10 [DatabaseIdentifier:12145768] PDB:4D18 [DatabaseIdentifier:12143963] PDB:6R6H [DatabaseIdentifier:12143949] PDB:6R7H [DatabaseIdentifier:12143948] PDB:6R7F [DatabaseIdentifier:12143929] PDB:8H3A [DatabaseIdentifier:12143924] PDB:8H3F [DatabaseIdentifier:12143936] PDB:8H38 [DatabaseIdentifier:12143950] PDB:6R7I [DatabaseIdentifier:12121413] OpenTargets:ENSG00000198612 [DatabaseIdentifier:11836928] HPA:ENSG00000198612-COPS8 [DatabaseIdentifier:11799348] GlyGen:Q99627 [DatabaseIdentifier:11783823] GeneCards:COPS8 [DatabaseIdentifier:11654534] ENSEMBL:ENST00000354371 [DatabaseIdentifier:11654535] ENSEMBL:ENST00000392008 [DatabaseIdentifier:11531836] ENSEMBL:ENSP00000375865 [DatabaseIdentifier:11531835] ENSEMBL:ENSP00000346340 [DatabaseIdentifier:11445132] ENSEMBL:ENSG00000198612
databaseName	UniProt
dbId	225822
description	recommendedName: COP9 signalosome complex subunit 8 shortName: SGN8 shortName: Signalosome subunit 8 alternativeName: COP9 homolog shortName: hCOP9 alternativeName: JAB1-containing signalosome subunit 8
displayName	UniProt:Q99627 COPS8
geneName	COPS8 CSN8
identifier	Q99627
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cytoplasm Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Signalosome
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	COPS8
otherIdentifier	10920 11742682_s_at 11749363_a_at 16892836 202141_PM_s_at 202141_s_at 202142_PM_at 202142_at 202143_PM_s_at 202143_s_at 214260_PM_at 214260_at 236204_PM_at 236204_at 2534132 2534133 2534134 2534137 2534138 2534140 2534144 2534145 2534147 2534148 2534149 2534150 2534151 2534152 2534153 2534154 2534156 2534157 2534158 2534159 2534160 2534161 2534162 2534163 2534164 2534165 2628555 2628556 32539_at 52526_at 8049478 A_14_P130167 A_23_P144257 A_33_P3230324 GE62469 GE861588 GO:0000338 GO:0005515 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006468 GO:0007250 GO:0008180 GO:0008285 GO:0010387 GO:0032991 GO:0045116 GO:0048471 GO:0070062 GO:2000434 HMNXSV003014115 Hs.34898.0.A1_3p_at ILMN_1705711 ILMN_2337941 ILMN_2373779 PH_hs_0030305 PH_hs_0033517 TC02001439.hg U51205_at g13111846_3p_a_at g5729778_3p_a_at g5729778_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-416962] COPS8 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5697014] COPS8 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12722136] UCSC:Q99627 COPS8 [ReferenceDNASequence:12107117] OMIM:616011 COPS8 [ReferenceDNASequence:12024695] NCBI Gene:10920 COPS8 [ReferenceDNASequence:11940602] Monarch:10920 COPS8 [ReferenceDNASequence:11854499] KEGG:hsa:10920 COPS8 [ReferenceDNASequence:11815444] HGNC:24335 COPS8 [ReferenceDNASequence:11434029] dbSNP Gene:10920 COPS8 [ReferenceDNASequence:11407570] CTD Gene:10920 COPS8 [ReferenceDNASequence:11397354] COSMIC - genes:COPS8 COPS8 [ReferenceDNASequence:11310813] BioGPS Gene:10920 COPS8 [ReferenceDNASequence:ensembl:ENSG00000198612] ENSEMBL:ENSG00000198612 COPS8
referenceTranscript	[ReferenceRNASequence:12492645] RefSeq:NM_006710.5 COPS8 [ReferenceRNASequence:12492644] RefSeq:NM_198189.3 COPS8
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CSN8_HUMAN A8K1H6 Q53QS9
sequenceLength	209
species	[Species:48887] Homo sapiens
stId	uniprot:Q99627
url	http://purl.uniprot.org/uniprot/Q99627

Referrals

(interactor)	[UndirectedInteraction:11304777] UniProt:Q92905 <-> UniProt:Q99627 (IntAct) [UndirectedInteraction:11282661] UniProt:Q15831 <-> UniProt:Q99627 (IntAct) [UndirectedInteraction:11223427] UniProt:P51813 <-> UniProt:Q99627 (IntAct) [UndirectedInteraction:11220265] UniProt:Q92466 <-> UniProt:Q99627 (IntAct) [UndirectedInteraction:11205847] UniProt:Q13616 <-> UniProt:Q99627 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-416962] COPS8 [cytosol] [EntityWithAccessionedSequence:R-HSA-5697014] COPS8 [nucleoplasm]