UniProt:Q99217 AMELX

chain
  • signal peptide:1-16
  • chain:17-191
checksum 322C88DA3F7155DC
comment
  • FUNCTION Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.SUBUNIT Interacts with KRT5.SUBCELLULAR LOCATION Additional isoforms seem to exist.DEVELOPMENTAL STAGE Transiently but abundantly expressed by ameloblasts during tooth development. Amelogenin is the predominant protein in developing dental enamel.PTM Phosphorylated by FAM20C in vitro.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the amelogenin family.
crossReference
databaseName UniProt
dbId 49934
description
  • recommendedName: Amelogenin, X isoform
displayName UniProt:Q99217 AMELX
geneName
  • AMELX
  • AMG
  • AMGX
identifier Q99217
isSequenceChanged false
keyword
  • Alternative splicing
  • Amelogenesis imperfecta
  • Biomineralization
  • Direct protein sequencing
  • Disease variant
  • Extracellular matrix
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • AMELX
otherIdentifier
  • 11738506_x_at
  • 11738781_a_at
  • 17101457
  • 208410_PM_x_at
  • 208410_x_at
  • 265
  • 32991_f_at
  • 34588_i_at
  • 34589_f_at
  • 3968751
  • 3968752
  • 3968755
  • 3968756
  • 3968757
  • 3968758
  • 3968759
  • 4033756
  • 8166006
  • A_23_P96478
  • GE80493
  • GO:0001649
  • GO:0001837
  • GO:0002062
  • GO:0005198
  • GO:0005509
  • GO:0005515
  • GO:0005576
  • GO:0005604
  • GO:0005788
  • GO:0007155
  • GO:0007165
  • GO:0007275
  • GO:0007584
  • GO:0008083
  • GO:0009410
  • GO:0009986
  • GO:0030139
  • GO:0030154
  • GO:0030312
  • GO:0030345
  • GO:0031012
  • GO:0031214
  • GO:0031402
  • GO:0031410
  • GO:0032967
  • GO:0032991
  • GO:0034505
  • GO:0042127
  • GO:0042475
  • GO:0042802
  • GO:0042803
  • GO:0046848
  • GO:0048018
  • GO:0048856
  • GO:0051592
  • GO:0062023
  • GO:0070166
  • GO:0070172
  • GO:0097186
  • GO:0098772
  • HMNXSV003018322
  • ILMN_2397406
  • M86933_s_at
  • PH_hs_0031201
  • TC0X000043.hg
  • g6715562_3p_at
  • g6715562_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • AMELX_HUMAN
  • Q96NW6
  • Q9UCA7
sequenceLength 191
species [Species:48887] Homo sapiens
stId uniprot:Q99217
url http://purl.uniprot.org/uniprot/Q99217
Cite Us!