UniProt:Q96T76 MMS19

chain
  • initiator methionine:1
  • chain:2-1030
checksum 7EC22CF0E38EFE1D
comment
  • FUNCTION Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity (PubMed:29848660). In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678361, PubMed:22678362, PubMed:23585563, PubMed:29225034). As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur (Fe-S) cluster assembly into ERCC2/XPD (PubMed:20797633). Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660). Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery (PubMed:11279242).SUBUNIT Component of the CIA complex (PubMed:22678361, PubMed:22678362, PubMed:23585563). In the CIA complex, interacts directly with CIAO2B and CIAO3 (PubMed:23585563). Component of the MMXD complex, composed of CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5 (PubMed:20797633). Interacts with CIAO2B; the interaction is direct (PubMed:20797633). Interacts with ERCC2/XPD; the interaction is direct (PubMed:11071939, PubMed:23585563). Interacts with ERCC3/XPB and NCOA3/RAC3 (PubMed:11071939, PubMed:11279242). Interacts with RTEL1; the interaction mediates the association of RTEL1 with the CIA complex (PubMed:22678361, PubMed:23585563). Interacts with BRIP1 (PubMed:23585563). Interacts with KIF4A; the interaction facilitates the transfer of Fe-S clusters to KIF4A to ensure proper localization of KIF4A to the mitotic machinery components (PubMed:29848660). Interacts with CCDC117; the interaction is indirect (PubMed:30742009).INTERACTION In mitosis, enriched on centrosomes during prophase, localizes to the spindle during metaphase and surrounds compacted spindle midzone microtubules during telophase.ALTERNATIVE PRODUCTS Ubiquitously expressed with higher expression in testis.PTM Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination by MAGEF1-NSMCE1 ubiquitin ligase complex leading to proteasomal degradation.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the MET18/MMS19 family.SEQUENCE CAUTION Wrong choice of CDS.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Wrong choice of CDS.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 237563
description
  • recommendedName: fullName evidence="17"MMS19 nucleotide excision repair protein homolog shortName: hMMS19 alternativeName: MET18 homolog alternativeName: MMS19-like protein
displayName UniProt:Q96T76 MMS19
geneName
  • MMS19
  • MMS19L
identifier Q96T76
isSequenceChanged false
keyword
  • Acetylation
  • Activator
  • Alternative splicing
  • Chromosome partition
  • Cytoplasm
  • Cytoskeleton
  • DNA damage
  • DNA repair
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • MMS19
otherIdentifier
  • 11717898_a_at
  • 16717176
  • 202167_PM_s_at
  • 202167_s_at
  • 3302359
  • 3302361
  • 3302362
  • 3302363
  • 3302364
  • 3302366
  • 3302367
  • 3302368
  • 3302369
  • 3302370
  • 3302371
  • 3302372
  • 3302373
  • 3302374
  • 3302375
  • 3302376
  • 3302377
  • 3302378
  • 3302379
  • 3302380
  • 3302381
  • 3302382
  • 3302383
  • 3302384
  • 3302385
  • 3302387
  • 3302388
  • 3302389
  • 3302390
  • 3302391
  • 3302392
  • 3302393
  • 3302394
  • 3302395
  • 3302396
  • 3302397
  • 3302398
  • 3302399
  • 3302400
  • 3302401
  • 3302405
  • 3302406
  • 3302407
  • 3302408
  • 3302410
  • 3302411
  • 3302413
  • 3302415
  • 3302416
  • 3302417
  • 3302418
  • 3302419
  • 3302423
  • 3302424
  • 3302425
  • 3302427
  • 35273_at
  • 64210
  • 7935474
  • A_23_P46982
  • A_24_P369263
  • GE54081
  • GO:0003713
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005675
  • GO:0005737
  • GO:0005813
  • GO:0005815
  • GO:0005819
  • GO:0005829
  • GO:0005856
  • GO:0006281
  • GO:0006355
  • GO:0006974
  • GO:0007059
  • GO:0016020
  • GO:0016226
  • GO:0019899
  • GO:0030159
  • GO:0030331
  • GO:0030674
  • GO:0043226
  • GO:0045893
  • GO:0051604
  • GO:0060090
  • GO:0071817
  • GO:0097361
  • HMNXSV003009965
  • HMNXSV003026454
  • ILMN_2174394
  • PH_hs_0015007
  • TC10001567.hg
  • g13375625_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MMS19_HUMAN
  • B0QZ75
  • B3KPE5
  • B4DQX2
  • B4E2I3
  • D3DR55
  • F8W9Y2
  • Q17RZ8
  • Q5T455
  • Q66K82
  • Q7L4W8
  • Q969Z1
  • Q96DF1
  • Q96MR1
  • Q96RK5
  • Q96SK1
  • Q9BUE2
  • Q9BYS9
sequenceLength 1030
species [Species:48887] Homo sapiens
stId uniprot:Q96T76
url http://purl.uniprot.org/uniprot/Q96T76
Cite Us!