UniProt:Q96ST2 IWS1

chain
  • chain:1-819
checksum C9749A2C2DC05D72
comment
  • FUNCTION Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.SUBUNIT Interacts with SUPT6H; binds preferentially to the POLR2A-bound SUPT6H. Interacts with ALYREF/THOC4, SETD2 and PRMT5. Interacts with HDGFRP2. Interacts (via IBM motif) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:29997176).SUBCELLULAR LOCATION Phosphorylation increases its interaction with PSIP1.SIMILARITY Belongs to the IWS1 family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 233174
description
  • recommendedName: Protein IWS1 homolog alternativeName: IWS1-like protein
displayName UniProt:Q96ST2 IWS1
geneName
  • IWS1
  • IWS1L
identifier Q96ST2
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • mRNA processing
  • mRNA splicing
  • mRNA transport
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
  • Transport
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • IWS1
otherIdentifier
  • 11717669_a_at
  • 16902502
  • 224768_PM_at
  • 224768_at
  • 224775_PM_at
  • 224775_at
  • 2574885
  • 2574888
  • 2574889
  • 2574892
  • 2574893
  • 2574894
  • 2574898
  • 2574899
  • 2574902
  • 2574904
  • 2574906
  • 2574908
  • 2574909
  • 2574910
  • 2574912
  • 2574913
  • 2574918
  • 2574919
  • 2574920
  • 2574921
  • 2574922
  • 2574923
  • 2574924
  • 2574925
  • 2574926
  • 2574932
  • 2574933
  • 2574935
  • 2574936
  • 2574937
  • 45816_at
  • 55677
  • 8055021
  • 90272_at
  • A_19_P00321761
  • A_23_P165574
  • A_33_P3269134
  • GE55887
  • GO:0001701
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0006325
  • GO:0006338
  • GO:0006397
  • GO:0006913
  • GO:0008380
  • GO:0010793
  • GO:0016071
  • GO:0016973
  • GO:0048856
  • GO:0050684
  • GO:0051028
  • GO:0140673
  • HMNXSV003009336
  • HMNXSV003038912
  • HMNXSV003056097
  • Hs.5570.0.A1_3p_at
  • Hs.5570.0.A1_3p_x_at
  • Hs.5570.0.A2_3p_at
  • ILMN_1747241
  • PH_hs_0022439
  • TC02002281.hg
  • TC02002282.hg
  • TC02004558.hg
  • TC02004559.hg
  • p20930
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IWS1_HUMAN
  • Q2TB65
  • Q6P157
  • Q8N3E8
  • Q96MI7
  • Q9NV97
  • Q9NWH8
sequenceLength 819
species [Species:48887] Homo sapiens
stId uniprot:Q96ST2
url http://purl.uniprot.org/uniprot/Q96ST2
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