UniProt:Q96QG7 MTMR9

chain
  • chain:1-549
checksum 910F7D2907F9707E
comment
  • FUNCTION Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598). Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598). Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate (PubMed:22647598). The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). Stabilizes MTMR8 protein levels (PubMed:22647598). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598). Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598). Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970).SUBUNIT Homodimer (PubMed:19038970). Heterodimer (via C-terminus) with lipid phosphatase MTMR6 (via C-terminus) (PubMed:12890864, PubMed:16787938, PubMed:19038970, PubMed:23188820). Heterodimer (via coiled coil domain) with lipid phosphatase MTMR7 (via C-terminus) (By similarity). Heterodimer with lipid phosphatase MTMR8 (PubMed:16787938, PubMed:22647598).INTERACTION Localizes to ruffles during EGF-induced macropinocytosis (By similarity). Colocalizes with MTMR6 to the perinuclear region (PubMed:19038970). Partially localizes to the endoplasmic reticulum (PubMed:19038970).ALTERNATIVE PRODUCTS Expressed in many tissues.DOMAIN The GRAM domain is required for cell membrane localization.DOMAIN The coiled coil domain mediates interaction with MTMR9.SIMILARITY Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.CAUTION Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 333 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.
crossReference
databaseName UniProt
dbId 95760
description
  • recommendedName: Myotubularin-related protein 9 alternativeName: fullName evidence="13"Inactive phosphatidylinositol 3-phosphatase 9
displayName UniProt:Q96QG7 MTMR9
geneName
  • MTMR9
  • C8orf9
  • MTMR8
identifier Q96QG7
isSequenceChanged false
keyword
  • Acetylation
  • Alternative splicing
  • Cell membrane
  • Cell projection
  • Coiled coil
  • Cytoplasm
  • Endocytosis
  • Endoplasmic reticulum
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • MTMR9
otherIdentifier
  • 11726138_at
  • 11726139_at
  • 11741523_x_at
  • 11749179_a_at
  • 1553340_3p_s_at
  • 1553340_PM_s_at
  • 1553340_s_at
  • 17065709
  • 17065726
  • 17117790
  • 204837_PM_at
  • 204837_at
  • 213278_PM_at
  • 213278_at
  • 2956386
  • 2956388
  • 3085875
  • 3085876
  • 3085878
  • 3085879
  • 3085881
  • 3085883
  • 3085884
  • 3085885
  • 3085886
  • 3085887
  • 3085888
  • 3085889
  • 3085891
  • 3085892
  • 3085893
  • 3085896
  • 3085897
  • 3085898
  • 3085899
  • 3085900
  • 3085902
  • 3085903
  • 3085904
  • 3085905
  • 36692_at
  • 3708698
  • 3708701
  • 3753476
  • 3753477
  • 3779190
  • 3779191
  • 3779192
  • 3779208
  • 3779209
  • 39607_at
  • 62179_at
  • 66036
  • 8004428
  • 8020162
  • 8144586
  • 8144600
  • A_14_P107378
  • A_23_P59988
  • A_23_P71389
  • A_24_P261052
  • GE55496
  • GE565091
  • GO:0005515
  • GO:0005737
  • GO:0005783
  • GO:0005829
  • GO:0005886
  • GO:0006629
  • GO:0006897
  • GO:0010507
  • GO:0010922
  • GO:0016020
  • GO:0016192
  • GO:0019903
  • GO:0030234
  • GO:0032587
  • GO:0032991
  • GO:0042995
  • GO:0046856
  • GO:0048471
  • GO:0050821
  • GO:0060304
  • HMNXSV003006043
  • HMNXSV003023559
  • Hs.27194.0.S2_3p_at
  • Hs.48802.0.S1_3p_at
  • Hs2.350567.1.S1_3p_at
  • Hs2.350567.1.S1_3p_s_at
  • ILMN_1652521
  • ILMN_1713315
  • ILMN_1715988
  • ILMN_2194619
  • PH_hs_0033614
  • PH_hs_0033915
  • TC08000084.hg
  • TC08000085.hg
  • TC17000097.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MTMR9_HUMAN
  • B7Z291
  • Q52LU3
  • Q8WW11
  • Q96QG6
  • Q9NX50
sequenceLength 549
species [Species:48887] Homo sapiens
stId uniprot:Q96QG7
url http://purl.uniprot.org/uniprot/Q96QG7

Referrals

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