UniProt:Q96MA6 AK8

chain
  • chain:1-479
checksum 9E4EABA3F429B731
comment
  • FUNCTION Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.CATALYTIC ACTIVITY AMP + ATP = 2 ADPCATALYTIC ACTIVITY a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADPCATALYTIC ACTIVITY a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADPBIOPHYSICOCHEMICAL PROPERTIES Interacts with CFAP45 and CFAP52; CFAP45 and AK8 dimerization may create a cavity at the interface of the dimer that can accommodate AMP.INTERACTION Located in the proximal region of respiratory cilia.ALTERNATIVE PRODUCTS Expressed in respiratory cells (at protein level).SIMILARITY Belongs to the adenylate kinase family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 223637
description
  • recommendedName: Adenylate kinase 8 shortName: AK 8 ecNumber evidence="2"2.7.4.3 ecNumber evidence="2 3"2.7.4.6 alternativeName: ATP-AMP transphosphorylase 8
displayName UniProt:Q96MA6 AK8
geneName
  • AK8
  • C9orf98
identifier Q96MA6
isSequenceChanged false
keyword
  • Alternative splicing
  • ATP-binding
  • Cell projection
  • Cytoplasm
  • Cytoskeleton
  • Kinase
  • Nucleotide-binding
  • Proteomics identification
  • Reference proteome
  • Transferase
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • AK8
otherIdentifier
  • 11734262_a_at
  • 158067
  • 17099338
  • 230976_PM_at
  • 230976_at
  • 3228280
  • 3228281
  • 3228282
  • 3228283
  • 3228284
  • 3228316
  • 3228328
  • 3228329
  • 3228333
  • 3228334
  • 3228335
  • 3228336
  • 3228337
  • 3228339
  • 3228340
  • 3228349
  • 3228350
  • 3228351
  • 3228353
  • 3228358
  • 3228360
  • 3228361
  • 3228366
  • 3228367
  • 3228368
  • 76497_at
  • 8164766
  • A_23_P83200
  • GE80434
  • GO:0000166
  • GO:0004017
  • GO:0004550
  • GO:0005515
  • GO:0005524
  • GO:0005737
  • GO:0005829
  • GO:0005856
  • GO:0005929
  • GO:0005930
  • GO:0006139
  • GO:0009117
  • GO:0009123
  • GO:0016208
  • GO:0016301
  • GO:0016740
  • GO:0016776
  • GO:0019205
  • GO:0021591
  • GO:0036126
  • GO:0036431
  • GO:0042995
  • GO:0043226
  • GO:0046940
  • GO:0048856
  • GO:0055086
  • GO:0097729
  • HMNXSV003013119
  • Hs.127769.0.A1_3p_at
  • ILMN_1659914
  • PH_hs_0019730
  • TC09001676.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • KAD8_HUMAN
  • A8K821
  • Q8N9W9
sequenceLength 479
species [Species:48887] Homo sapiens
stId uniprot:Q96MA6
url http://purl.uniprot.org/uniprot/Q96MA6
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