FUNCTION Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (By similarity). Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis (PubMed:12490704). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:32669547). The male germ cell-specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome (By similarity). It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm (By similarity).SUBUNIT Component of a male germ cell-specific 60S large ribosomal subunit (LSU), which contains RPL10L and RPL39L, instead of RPL10 and RPL39 paralogs (PubMed:23636399, PubMed:25901680, PubMed:32669547). The composition of the rest of the complex is similar to classical ribosomes (By similarity).INTERACTION Almost testis-specific (PubMed:12490704, PubMed:19333399, PubMed:28502657). Also expressed in pre- and postmenopausal ovary (PubMed:19333399).DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS This gene has no introns in its coding regions, and therefore was most likely produced by retrotransposition of the original X-linked gene during evolution.SIMILARITY Belongs to the universal ribosomal protein uL16 family.
recommendedName: fullName evidence="10"Ribosomal protein uL16-like alternativeName: fullName evidence="9"60S ribosomal protein L10-like alternativeName: Large ribosomal subunit protein uL16-like
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