Reactome | UniProt:Q96JA1 LRIG1

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UniProt:Q96JA1 LRIG1 Show undefined attributes

chain	signal peptide:1-34 chain:35-1093
checksum	7B4F13CA343AF943
comment	FUNCTION Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.SUBUNIT Interacts (via extracellular LRR and Ig-like domains) with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 (via extracellular domain) (PubMed:15282549). The physiological relevance of the interaction is controversial; LRIG1 may have low affinity for EGFR, and interaction may occur only when high levels of both proteins are present (PubMed:25765764).INTERACTION Widely expressed.INDUCTION By EGF.DOMAIN Contains LRR and Ig-domains that can mediate low-affinity interaction with EGFR (PubMed:25765764). The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when both the LRRs and the Ig-domains are deleted (PubMed:15282549).
created	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference	[DatabaseIdentifier:12474189] RefSeq:NP_056356.2 [DatabaseIdentifier:11522250] ENSEMBL:ENSG00000144749 [DatabaseIdentifier:11642186] ENSEMBL:ENSP00000373208 [DatabaseIdentifier:11642187] ENSEMBL:ENSP00000273261 [DatabaseIdentifier:11764885] ENSEMBL:ENST00000273261 [DatabaseIdentifier:11764886] ENSEMBL:ENST00000383703 [DatabaseIdentifier:11792630] GeneCards:LRIG1 [DatabaseIdentifier:11808706] GlyGen:Q96JA1 [DatabaseIdentifier:11845620] HPA:ENSG00000144749-LRIG1 [DatabaseIdentifier:12130268] OpenTargets:ENSG00000144749 [DatabaseIdentifier:12213774] PDB:4U7L [DatabaseIdentifier:12213775] PDB:4U7M [DatabaseIdentifier:12273105] PRO:Q96JA1 [DatabaseIdentifier:12290474] Pharos - Targets:Q96JA1
databaseName	UniProt
dbId	149710
description	recommendedName: Leucine-rich repeats and immunoglobulin-like domains protein 1 shortName evidence="10"LIG-1
displayName	UniProt:Q96JA1 LRIG1
geneName	LRIG1 LIG1
identifier	Q96JA1
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Leucine-rich repeat Membrane Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	LRIG1
otherIdentifier	11750405_a_at 11755110_a_at 16955939 211596_PM_s_at 211596_s_at 238339_PM_x_at 238339_x_at 240140_PM_s_at 240140_s_at 26018 2680602 2680603 2680604 2680605 2680606 2680607 2680610 2680612 2680613 2680614 2680617 2680620 2680621 2680622 2680625 2680630 2680631 2680633 2680634 2680636 2680637 2680640 2680641 2680642 2680644 2680645 2680646 2680660 2680661 2680669 2680672 2680683 2680684 2680685 34800_at 63691_at 70503_at 8088642 A_23_P109636 GE56536 GO:0005515 GO:0005886 GO:0007605 GO:0016020 GO:0022405 GO:0032474 GO:0038023 GO:0050877 GO:0060384 HMNXSV003006438 Hs.121706.1.S1_3p_s_at Hs.207432.0.A1_3p_s_at ILMN_1707342 ILMN_2128795 PH_hs_0022789 PH_hs_0034614 TC03001532.hg g13537354_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-197745] LRIG1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8875434] Ub-LRIG1 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000144749] ENSEMBL:ENSG00000144749 LRIG1 [ReferenceDNASequence:12716438] UCSC:Q96JA1 LRIG1 [ReferenceDNASequence:11386115] BioGPS Gene:26018 LRIG1 [ReferenceDNASequence:11393347] COSMIC - genes:LIG1 LIG1 [ReferenceDNASequence:11396501] COSMIC - genes:LRIG1 LRIG1 [ReferenceDNASequence:11420853] CTD Gene:26018 LRIG1 [ReferenceDNASequence:11432961] dbSNP Gene:26018 LRIG1 [ReferenceDNASequence:11824313] HGNC:17360 LRIG1 [ReferenceDNASequence:11922636] KEGG:hsa:26018 LRIG1 [ReferenceDNASequence:12015904] Monarch:26018 LRIG1 [ReferenceDNASequence:12099997] NCBI Gene:26018 LRIG1 [ReferenceDNASequence:12114845] OMIM:608868 LRIG1
referenceTranscript	[ReferenceRNASequence:12655656] RefSeq:NM_015541.3 LRIG1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	LRIG1_HUMAN Q6IQ51 Q96CF9 Q9BYB8 Q9UFI4
sequenceLength	1093
species	[Species:48887] Homo sapiens
stId	uniprot:Q96JA1
url	http://purl.uniprot.org/uniprot/Q96JA1

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-197745] LRIG1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-8875434] Ub-LRIG1 [plasma membrane]
(referenceSequence)	[GroupModifiedResidue:8875437] ubiquitinylated lysine (Ub [cytosol]) at unknown position
(interactor)	[UndirectedInteraction:11130233] UniProt:Q96JA1 <-> UniProt:P04626 (IntAct) [UndirectedInteraction:11130235] UniProt:Q96JA1 <-> UniProt:P00533 (IntAct) [UndirectedInteraction:11130239] UniProt:Q96JA1 <-> UniProt:Q6UXM1 (IntAct) [UndirectedInteraction:11130241] UniProt:Q96JA1 <-> UniProt:Q15303 (IntAct) [UndirectedInteraction:11130243] UniProt:Q96JA1 <-> UniProt:P20338 (IntAct) [UndirectedInteraction:11130247] UniProt:Q96JA1 <-> UniProt:O14967 (IntAct) [UndirectedInteraction:11130249] UniProt:Q96JA1 <-> UniProt:Q9UK22 (IntAct) [UndirectedInteraction:11130251] UniProt:Q96JA1 <-> UniProt:Q9BT09 (IntAct) [UndirectedInteraction:11130255] UniProt:Q96JA1 <-> UniProt:O94898 (IntAct) [UndirectedInteraction:11130257] UniProt:Q96JA1 <-> UniProt:Q3ZCM7 (IntAct) [UndirectedInteraction:11130259] UniProt:Q96JA1 <-> UniProt:P13747 (IntAct) [UndirectedInteraction:11130263] UniProt:Q96JA1 <-> UniProt:Q99445 (IntAct) [UndirectedInteraction:11130265] UniProt:Q96JA1 <-> UniProt:Q8WVQ1 (IntAct) [UndirectedInteraction:11130267] UniProt:Q96JA1 <-> UniProt:Q99999 (IntAct) [UndirectedInteraction:11130271] UniProt:Q96JA1 <-> UniProt:Q9H9A6 (IntAct) [UndirectedInteraction:11130273] UniProt:Q96JA1 <-> UniProt:P22681 (IntAct) [UndirectedInteraction:11130277] UniProt:Q96JA1 <-> UniProt:Q8WWI1-3 (IntAct) [UndirectedInteraction:11130281] UniProt:Q96JA1 <-> UniProt:P00533-4 (IntAct) [UndirectedInteraction:11130285] UniProt:Q96JA1 <-> UniProt:Q9UPQ0-1 (IntAct)

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