UniProt:Q96GC6 ZNF274

chain
  • chain:1-653
checksum 8B91F51F4BEED925
comment
  • FUNCTION Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).SUBUNIT Interacts with SETDB1 and TRIM28/KAP1. Interacts with ATRX. Forms a complex with ATRX, SETDB1 and TRIM28 (PubMed:27029610).SUBCELLULAR LOCATION Experimental confirmation may be lacking for some isoforms.SIMILARITY Belongs to the krueppel C2H2-type zinc-finger protein family.
crossReference
databaseName UniProt
dbId 67996
description
  • recommendedName: Neurotrophin receptor-interacting factor homolog alternativeName: Zinc finger protein 274 alternativeName: Zinc finger protein HFB101 alternativeName: Zinc finger protein with KRAB and SCAN domains 19 alternativeName: Zinc finger protein zfp2 shortName: Zf2
displayName UniProt:Q96GC6 ZNF274
geneName
  • ZNF274
  • ZKSCAN19
  • SP2114
identifier Q96GC6
isSequenceChanged false
keyword
  • Alternative splicing
  • Cytoplasm
  • DNA-binding
  • Metal-binding
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Repressor
  • Transcription
  • Transcription regulation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • ZNF274
otherIdentifier
  • 10782
  • 11753327_a_at
  • 11758517_s_at
  • 11761185_a_at
  • 11762103_a_at
  • 16866221
  • 204937_PM_s_at
  • 204937_s_at
  • 232436_PM_at
  • 232436_at
  • 3843799
  • 3843800
  • 3843801
  • 3843802
  • 3843803
  • 3843804
  • 3843805
  • 3843806
  • 3843807
  • 3843808
  • 3843809
  • 3843810
  • 3843811
  • 3843812
  • 3843813
  • 3843814
  • 3843815
  • 3843816
  • 3843817
  • 3843818
  • 3843819
  • 3843820
  • 3843821
  • 3843822
  • 3843823
  • 3843824
  • 3843825
  • 3843831
  • 3874226
  • 40691_at
  • 75383_at
  • 8031871
  • A_14_P119622
  • A_23_P153251
  • GE53753
  • GO:0000122
  • GO:0000978
  • GO:0000981
  • GO:0003677
  • GO:0003682
  • GO:0005515
  • GO:0005634
  • GO:0005730
  • GO:0005737
  • GO:0006325
  • GO:0006338
  • GO:0006355
  • GO:0006357
  • GO:0008270
  • GO:0043565
  • GO:0046872
  • GO:1990837
  • HMNXSV003042342
  • Hs.143263.0.S1_3p_at
  • ILMN_1688629
  • ILMN_1714274
  • ILMN_2352574
  • PH_hs_0004778
  • TC19000956.hg
  • U71598_at
  • g7706506_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ZN274_HUMAN
  • Q53XU4
  • Q6MZG1
  • Q8WY37
  • Q8WY38
  • Q92969
  • Q9UII0
  • Q9UII1
sequenceLength 653
species [Species:48887] Homo sapiens
stId uniprot:Q96GC6
url http://purl.uniprot.org/uniprot/Q96GC6
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