Reactome | UniProt:Q96FF9 CDCA5

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UniProt:Q96FF9 CDCA5 Show undefined attributes

chain	chain:1-252
checksum	A4CD6768D3464040
comment	FUNCTION Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.SUBUNIT Interacts with the APC/C complex (By similarity). Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3. Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of PDS5A with WAPL.INTERACTION Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.DOMAIN The KEN box is required for the association with the APC/C complex.PTM Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPL by CDCA5.PTM Ubiquitinated by the APC/C complex in G1, leading to its degradation.MISCELLANEOUS Named sororin after the Latin word 'soror', which means 'sister', because of its critical role in sister chromatid cohesion.SIMILARITY Belongs to the sororin family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12478122] RefSeq:NP_542399.1 [DatabaseIdentifier:12292101] Pharos - Targets:Q96FF9 [DatabaseIdentifier:12274968] PRO:Q96FF9 [DatabaseIdentifier:12131917] OpenTargets:ENSG00000146670 [DatabaseIdentifier:11847245] HPA:ENSG00000146670-CDCA5 [DatabaseIdentifier:11810208] GlyGen:Q96FF9 [DatabaseIdentifier:11794267] GeneCards:CDCA5 [DatabaseIdentifier:11767563] ENSEMBL:ENST00000275517 [DatabaseIdentifier:11644864] ENSEMBL:ENSP00000275517 [DatabaseIdentifier:11523951] ENSEMBL:ENSG00000146670
databaseName	UniProt
dbId	222533
description	recommendedName: Sororin alternativeName: Cell division cycle-associated protein 5 alternativeName: p35
displayName	UniProt:Q96FF9 CDCA5
geneName	CDCA5
identifier	Q96FF9
isSequenceChanged	false
keyword	Cell cycle Cell division Chromosome Cytoplasm Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	CDCA5
otherIdentifier	113130 11718182_at 11718183_at 16740282 224753_PM_at 224753_at 3377415 3377417 3377419 3377420 3377421 3377422 3377424 3377425 3377426 3377427 3377428 3377429 3377430 3377431 3377432 3377433 3377434 3377435 3377436 3377437 3377438 3377439 3377440 3377442 44037_at 7949364 A_21_P0007135 A_23_P104651 A_33_P3277575 GE478996 GO:0000775 GO:0000785 GO:0003682 GO:0005515 GO:0005634 GO:0005654 GO:0005694 GO:0005737 GO:0005829 GO:0006281 GO:0006302 GO:0007064 GO:0044877 GO:0051301 HMNXSV003000110 HMNXSV003019022 HMNXSV003023496 HMNXSV003056557 Hs.23044.2.A1_3p_at ILMN_1683450 PH_hs_0020362 PH_hs_0032427 TC11001923.hg TC11001924.hg TC11003201.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2468266] p-S21,S75,T159-CDCA5 [chromosome] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2484804] p-S21,S75,T159-CDCA5 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2468269] p-S21,S75,T159-CDCA5 [chromosome, centromeric region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2468149] CDCA5 [chromosome] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2468260] CDCA5 [chromosome, centromeric region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2466357] CDCA5 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12717527] UCSC:Q96FF9 CDCA5 [ReferenceDNASequence:12116328] OMIM:609374 CDCA5 [ReferenceDNASequence:12101657] NCBI Gene:113130 CDCA5 [ReferenceDNASequence:12017564] Monarch:113130 CDCA5 [ReferenceDNASequence:11924186] KEGG:hsa:113130 CDCA5 [ReferenceDNASequence:11825962] HGNC:14626 CDCA5 [ReferenceDNASequence:11433211] dbSNP Gene:113130 CDCA5 [ReferenceDNASequence:11422979] CTD Gene:113130 CDCA5 [ReferenceDNASequence:11396698] COSMIC - genes:CDCA5 CDCA5 [ReferenceDNASequence:11387775] BioGPS Gene:113130 CDCA5 [ReferenceDNASequence:ensembl:ENSG00000146670] ENSEMBL:ENSG00000146670 CDCA5
referenceTranscript	[ReferenceRNASequence:12659626] RefSeq:NM_080668.4 CDCA5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CDCA5_HUMAN A8K625
sequenceLength	252
species	[Species:48887] Homo sapiens
stId	uniprot:Q96FF9
url	http://purl.uniprot.org/uniprot/Q96FF9

Referrals

(interactor)	[UndirectedInteraction:11270817] UniProt:Q96FF9 <-> UniProt:Q8N3U4-2 (IntAct) [UndirectedInteraction:11270815] UniProt:Q96FF9 <-> UniProt:Q8WVM7 (IntAct) [UndirectedInteraction:11270813] UniProt:Q96FF9 <-> UniProt:Q9BSU3 (IntAct) [UndirectedInteraction:11270811] UniProt:Q96FF9 <-> UniProt:Q9CW03 (IntAct) [UndirectedInteraction:11270809] UniProt:Q96FF9 <-> UniProt:Q29RF7 (IntAct) [UndirectedInteraction:11270807] UniProt:Q96FF9 <-> UniProt:Q8N3U4 (IntAct) [UndirectedInteraction:11270805] UniProt:Q96FF9 <-> UniProt:P41227 (IntAct) [UndirectedInteraction:11270803] UniProt:Q96FF9 <-> UniProt:Q9UQE7 (IntAct) [UndirectedInteraction:11270801] UniProt:Q96FF9 <-> UniProt:Q14683 (IntAct) [UndirectedInteraction:11251647] UniProt:Q5FBB7 <-> UniProt:Q96FF9 (IntAct) [UndirectedInteraction:11164795] UniProt:O60216 <-> UniProt:Q96FF9 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2468266] p-S21,S75,T159-CDCA5 [chromosome] [EntityWithAccessionedSequence:R-HSA-2484804] p-S21,S75,T159-CDCA5 [cytosol] [EntityWithAccessionedSequence:R-HSA-2468269] p-S21,S75,T159-CDCA5 [chromosome, centromeric region] [EntityWithAccessionedSequence:R-HSA-2468149] CDCA5 [chromosome] [EntityWithAccessionedSequence:R-HSA-2468260] CDCA5 [chromosome, centromeric region] [EntityWithAccessionedSequence:R-HSA-2466357] CDCA5 [nucleoplasm]
(referenceSequence)	[ModifiedResidue:2468267] O-phospho-L-serine at 75 [ModifiedResidue:2468265] O-phospho-L-threonine at 159 [ModifiedResidue:2468270] O-phospho-L-serine at 21

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