UniProt:Q96E17 RAB3C

chain
  • chain:1-227
checksum 7352E205DEFAC72D
comment
  • FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation.SUBUNIT Interacts with RIMS1, RIMS2, RPH3A and RPH3AL (By similarity). The GTP-bound form interacts with REP15 (PubMed:35871249). Interacts with GDI2, CHM and CHML; phosphorylation at Thr-94 disrupts these interactions (PubMed:29125462). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).INTERACTION Expressed in brain, placenta and lung.DOMAIN Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.PTM Phosphorylation of Thr-94 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitor GDI2.SIMILARITY Belongs to the small GTPase superfamily. Rab family.
crossReference
databaseName UniProt
dbId 62794
description
  • recommendedName: Ras-related protein Rab-3C ecNumber evidence="11"3.6.5.2
displayName UniProt:Q96E17 RAB3C
geneName
  • RAB3C
identifier Q96E17
isSequenceChanged false
keyword
  • 3D-structure
  • Cell membrane
  • GTP-binding
  • Hydrolase
  • Lipoprotein
  • Magnesium
  • Membrane
  • Metal-binding
  • Methylation
  • Nucleotide-binding
  • Phosphoprotein
  • Prenylation
  • Protein transport
  • Proteomics identification
  • Reference proteome
  • Transport
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • RAB3C
otherIdentifier
  • 115827
  • 11735055_at
  • 16985043
  • 229300_PM_at
  • 229300_at
  • 242328_PM_at
  • 242328_at
  • 244170_PM_at
  • 244170_at
  • 2810806
  • 2810807
  • 2810811
  • 2810813
  • 2810817
  • 2810818
  • 2810824
  • 2810829
  • 2810830
  • 2810844
  • 2810850
  • 2810855
  • 2810856
  • 2810857
  • 2810858
  • 2810860
  • 2810862
  • 2810863
  • 2810865
  • 2810866
  • 2810867
  • 46049_at
  • 52077_at
  • 79800_at
  • 8105487
  • 91592_at
  • A_14_P117966
  • A_23_P44794
  • A_32_P77831
  • A_33_P3250939
  • A_33_P3314559
  • GE476683
  • GE898522
  • GO:0000166
  • GO:0002376
  • GO:0003924
  • GO:0005515
  • GO:0005525
  • GO:0005768
  • GO:0005886
  • GO:0006887
  • GO:0008021
  • GO:0015031
  • GO:0016020
  • GO:0016192
  • GO:0016787
  • GO:0017157
  • GO:0019882
  • GO:0030742
  • GO:0031410
  • GO:0031489
  • GO:0031982
  • GO:0043226
  • GO:0046872
  • GO:0048471
  • HMNXSV003030299
  • HMNXSV003030708
  • Hs.184691.0.A1_3p_at
  • Hs.201198.0.A1_3p_at
  • Hs.4290.0.A1_3p_at
  • ILMN_1685750
  • ILMN_1870705
  • PH_hs_0010874
  • PH_hs_0012864
  • TC05000254.hg
  • TC05002391.hg
  • p26308
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RAB3C_HUMAN
sequenceLength 227
species [Species:48887] Homo sapiens
stId uniprot:Q96E17
url http://purl.uniprot.org/uniprot/Q96E17
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