Reactome | UniProt:Q96DR8 MUCL1

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UniProt:Q96DR8 MUCL1 Show undefined attributes

chain	signal peptide:1-20 chain:21-90
checksum	FEA58A2833B07262
comment	FUNCTION May play a role as marker for the diagnosis of metastatic breast cancer.INTERACTION Expressed in mammary, salivary glands and prostate. Also detected in lung. Mainly expressed in cancer cell lines of breast origin. Highly expressed in lymph node-positive compared with node-negative tumors. Detected in all lymph node containing metastatic cells.PTM O-glycosylated.POLYMORPHISM The number of repeats varies from 3 to 2 in one variant form which is equally present in breast cancer tumors.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:11807297] GlyGen:Q96DR8 [DatabaseIdentifier:12469595] RefSeq:NP_477521.1 [DatabaseIdentifier:12469596] RefSeq:XP_047284228.1 [DatabaseIdentifier:12289156] Pharos - Targets:Q96DR8 [DatabaseIdentifier:12270910] PRO:Q96DR8 [DatabaseIdentifier:12128944] OpenTargets:ENSG00000172551 [DatabaseIdentifier:11844319] HPA:ENSG00000172551-MUCL1 [DatabaseIdentifier:11520190] ENSEMBL:ENSG00000172551 [DatabaseIdentifier:11638938] ENSEMBL:ENSP00000311364 [DatabaseIdentifier:11761637] ENSEMBL:ENST00000308796 [DatabaseIdentifier:11791317] GeneCards:MUCL1
databaseName	UniProt
dbId	238212
description	recommendedName: Mucin-like protein 1 alternativeName: Protein BS106 alternativeName: Small breast epithelial mucin
displayName	UniProt:Q96DR8 MUCL1
geneName	MUCL1 SBEM UNQ590/PRO1160
identifier	Q96DR8
isSequenceChanged	false
keyword	Direct protein sequencing Glycoprotein Membrane Proteomics identification Reference proteome Repeat Secreted Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	MUCL1
otherIdentifier	11731021_a_at 118430 1553602_PM_at 1553602_at 16752132 3416703 3416704 3416705 3416706 3416707 3416708 3416709 3416710 53579_at 7955963 A_14_P115226 A_14_P200640 A_23_P150979 GE515737 GO:0005515 GO:0005576 GO:0005796 GO:0005886 GO:0016020 HMNXSV003005127 Hs2.348419.1.S1_3p_at ILMN_1810978 TC12000471.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-8858459] GalNAc-MUCL1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1462316] Core 2 (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6784294] Core 2a (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1462357] T-antigen (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-913643] GalNAc-MUCL1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-913632] MUCL1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1463594] Sialyl Tn antigen (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1463467] Sialyl-2,3 T-antigen (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1463524] Sialyl T-antigen (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1463480] Disialyl T-antigen (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1462246] Core 6 (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1967042] extended Core 6 (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1462181] Core 7 (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1462268] Core 3 (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1462139] Core 4 (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1462337] Core 5 (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6786344] Core 2S (MUCL1) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1462256] Core 8 (MUCL1) [Golgi lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000172551] ENSEMBL:ENSG00000172551 MUCL1 [ReferenceDNASequence:12715189] UCSC:Q96DR8 MUCL1 [ReferenceDNASequence:12113647] OMIM:610857 MUCL1 [ReferenceDNASequence:12098021] NCBI Gene:118430 MUCL1 [ReferenceDNASequence:12013928] Monarch:118430 MUCL1 [ReferenceDNASequence:11920775] KEGG:hsa:118430 MUCL1 [ReferenceDNASequence:11822987] HGNC:30588 MUCL1 [ReferenceDNASequence:11384139] BioGPS Gene:118430 MUCL1 [ReferenceDNASequence:11396215] COSMIC - genes:MUCL1 MUCL1 [ReferenceDNASequence:11418993] CTD Gene:118430 MUCL1 [ReferenceDNASequence:11432595] dbSNP Gene:118430 MUCL1
referenceTranscript	[ReferenceRNASequence:12651065] RefSeq:XM_047428272.1 MUCL1 [ReferenceRNASequence:12651064] RefSeq:NM_058173.3 MUCL1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MUCL1_HUMAN Q0VG95 Q32ZB5
sequenceLength	90
species	[Species:48887] Homo sapiens
stId	uniprot:Q96DR8
url	http://purl.uniprot.org/uniprot/Q96DR8

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-8858459] GalNAc-MUCL1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-1462316] Core 2 (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-6784294] Core 2a (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-1462357] T-antigen (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-913643] GalNAc-MUCL1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-913632] MUCL1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-1463594] Sialyl Tn antigen (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-1463467] Sialyl-2,3 T-antigen (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-1463524] Sialyl T-antigen (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-1463480] Disialyl T-antigen (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-1462246] Core 6 (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-1967042] extended Core 6 (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-1462181] Core 7 (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-1462268] Core 3 (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-1462139] Core 4 (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-1462337] Core 5 (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-6786344] Core 2S (MUCL1) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-1462256] Core 8 (MUCL1) [Golgi lumen]
(referenceSequence)	[ModifiedResidue:913653] O-(N-acetylamino)galactosyl-L-serine at unknown position [GroupModifiedResidue:1462292] O-(N-acetylamino)galactosyl-L-serine (Gal-beta1,3(GlcNAc-beta1,6)GalNAc-alpha group) at unknown position [GroupModifiedResidue:6784265] O-(N-acetylamino)galactosyl-L-serine (N-acetyl-beta-D-glucosaminyl-(1->6)-(N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-galactosyl-(1->3))-N-acetyl-alpha-D-galactosaminyl group) at unknown position [GroupModifiedResidue:1462097] O-(N-acetylamino)galactosyl-L-serine (beta-D-Galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl group) at unknown position [GroupModifiedResidue:1463510] O-(N-acetylamino)galactosyl-L-serine (Neu5Ac-alpha2,6-GalNAc-alpha group) at unknown position [GroupModifiedResidue:1463563] O-(N-acetylamino)galactosyl-L-serine (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl group) at unknown position [GroupModifiedResidue:1463530] O-(N-acetylamino)galactosyl-L-serine (Gal-beta1,3(Neu5Ac-alpha2,6)GalNAc-alpha group) at unknown position [GroupModifiedResidue:1463586] O-(N-acetylamino)galactosyl-L-serine (Neu5Ac-2,6(Neu5Ac-alpha2,3Gal-beta1,3)GalNAc-alpha group) at unknown position [GroupModifiedResidue:1462321] O-(N-acetylamino)galactosyl-L-serine (GlcNAc-beta1,6-GalNAc-alpha group) at unknown position [GroupModifiedResidue:1967017] O-(N-acetylamino)galactosyl-L-serine (Gal-beta1,4-GlcNAc-beta1,6-GalNAc-alpha group) at unknown position [GroupModifiedResidue:1462224] O-(N-acetylamino)galactosyl-L-serine (GalNAc-alpha1,6-GalNAc-alpha group) at unknown position [GroupModifiedResidue:1462132] O-(N-acetylamino)galactosyl-L-serine (GlcNAc-beta1,3-GalNAc-alpha group) at unknown position [GroupModifiedResidue:1462317] O-(N-acetylamino)galactosyl-L-serine (GlcNAc-beta1,3(GlcNAc-beta1,6)GalNac-alpha group) at unknown position [GroupModifiedResidue:1462147] O-(N-acetylamino)galactosyl-L-serine (GlcNAc-alpha1,3-GalNAc-alpha group) at unknown position [GroupModifiedResidue:6786337] O-(N-acetylamino)galactosyl-L-serine (6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)-(beta-D-galactosyl-(1->3))-N-acetyl-alpha-D-galactosaminyl group) at unknown position [GroupModifiedResidue:1462252] O-(N-acetylamino)galactosyl-L-serine (Gal-alpha1,3-GalNAc-alpha group) at unknown position
(interactor)	[UndirectedInteraction:11134167] UniProt:Q5J8M3 <-> UniProt:Q96DR8 (IntAct) [UndirectedInteraction:11173849] UniProt:Q14554 <-> UniProt:Q96DR8 (IntAct) [UndirectedInteraction:11203063] UniProt:Q3SXY8 <-> UniProt:Q96DR8 (IntAct)