UniProt:Q96C23 GALM

chain
  • initiator methionine:1
  • chain:2-342
checksum 611A54AE7E85813E
comment
  • FUNCTION Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism (PubMed:12753898). Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase) (PubMed:30451973). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1 (PubMed:12753898). Also active on D-glucose although shows a preference for galactose over glucose (PubMed:12753898).CATALYTIC ACTIVITY alpha-D-galactose = beta-D-galactoseCATALYTIC ACTIVITY alpha-D-glucose = beta-D-glucoseBIOPHYSICOCHEMICAL PROPERTIES kcat is 12000 sec(-1) with galactose as substrate (PubMed:12753898). kcat is 4900 sec(-1) with glucose as substrate (PubMed:12753898).PATHWAY Carbohydrate metabolism; hexose metabolism.PATHWAY Carbohydrate metabolism; galactose metabolism.SUBUNIT Monomer.SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the aldose epimerase family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 230220
description
  • recommendedName: fullName evidence="5 6"Galactose mutarotase ecNumber evidence="2"5.1.3.3 alternativeName: fullName evidence="5"Aldose 1-epimerase
displayName UniProt:Q96C23 GALM
geneName
  • GALM
  • BLOCK25
identifier Q96C23
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Carbohydrate metabolism
  • Cytoplasm
  • Disease variant
  • Isomerase
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • GALM
otherIdentifier
  • 11731413_at
  • 11731414_at
  • 130589
  • 16879250
  • 234974_PM_at
  • 234974_at
  • 235256_PM_s_at
  • 235256_s_at
  • 2477934
  • 2477935
  • 2477937
  • 2477938
  • 2477939
  • 2477941
  • 2477945
  • 2477955
  • 2477956
  • 2477957
  • 2477958
  • 2477959
  • 2477960
  • 2477961
  • 2477962
  • 2477963
  • 63556_i_at
  • 77653_at
  • 77894_at
  • 8041542
  • A_14_P114988
  • A_23_P67971
  • A_24_P212539
  • A_33_P3273436
  • GE532214
  • GO:0003824
  • GO:0004034
  • GO:0005737
  • GO:0005975
  • GO:0006006
  • GO:0006012
  • GO:0016853
  • GO:0019318
  • GO:0030246
  • GO:0033499
  • GO:0070062
  • HMNXSV003016243
  • Hs.264610.1.A1_3p_a_at
  • ILMN_1671482
  • PH_hs_0013661
  • TC02000245.hg
  • U11036_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GALM_HUMAN
  • Q53RY1
  • Q8NIA2
  • V9HWA8
sequenceLength 342
species [Species:48887] Homo sapiens
stId uniprot:Q96C23
url http://purl.uniprot.org/uniprot/Q96C23
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