UniProt:Q96BP3 PPWD1

chain
  • initiator methionine:1
  • chain:2-646
checksum 4DEFA1C78F914430
comment
  • FUNCTION PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638).CATALYTIC ACTIVITY [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)ACTIVITY REGULATION Inhibited by cyclosporin A (CsA).SUBUNIT Identified in the spliceosome C complex.SUBCELLULAR LOCATION Associated with spliceosomal complexes.ALTERNATIVE PRODUCTS Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 243716
description
  • recommendedName: fullName evidence="7"Peptidylprolyl isomerase domain and WD repeat-containing protein 1 ecNumber evidence="5"5.2.1.8 alternativeName: fullName evidence="8"Spliceosome-associated cyclophilin
displayName UniProt:Q96BP3 PPWD1
geneName
  • PPWD1
  • KIAA0073
identifier Q96BP3
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Isomerase
  • mRNA processing
  • mRNA splicing
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Rotamase
  • Spliceosome
  • WD repeat
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • PPWD1
otherIdentifier
  • 11744564_a_at
  • 11744565_s_at
  • 11746892_a_at
  • 11750421_a_at
  • 16985277
  • 213483_PM_at
  • 213483_at
  • 23398
  • 2812274
  • 2812275
  • 2812277
  • 2812278
  • 2812282
  • 2812283
  • 2812284
  • 2812285
  • 2812286
  • 2812287
  • 2812288
  • 2812290
  • 2812291
  • 2812292
  • 2812293
  • 2812296
  • 2812297
  • 2812298
  • 2812299
  • 2812300
  • 2812301
  • 2812302
  • 2812304
  • 2812305
  • 2812306
  • 2812307
  • 2812308
  • 2812309
  • 41638_at
  • 8105633
  • A_14_P103759
  • A_23_P110433
  • D38552_at
  • GE57196
  • GO:0000398
  • GO:0000413
  • GO:0003755
  • GO:0003824
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005681
  • GO:0006397
  • GO:0006457
  • GO:0008380
  • GO:0016071
  • GO:0016604
  • GO:0016853
  • GO:0071013
  • GO:0140096
  • HMNXSV003022653
  • Hs.1191.0.S1_3p_at
  • ILMN_2223380
  • PH_hs_0000157
  • TC05000277.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PPWD1_HUMAN
  • B4DWR9
  • Q15002
  • Q7KZ89
sequenceLength 646
species [Species:48887] Homo sapiens
stId uniprot:Q96BP3
url http://purl.uniprot.org/uniprot/Q96BP3
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