Reactome | UniProt:Q96BM9 ARL8A

Schema > ReferenceGeneProduct > Entries

UniProt:Q96BM9 ARL8A Show undefined attributes

chain	chain:1-186
checksum	EE5141235CE0F414
comment	FUNCTION Plays a role in lysosome motility (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity).SUBUNIT Interacts with PLEKHM1 (PubMed:28325809). When GTP-bound, interacts with RUFY3 and RUFY4, but not with RUFY1, nor RUFY2 (PubMed:35314674).INTERACTION Localizes with microtubules at the spindle mid-zone during mitosis.TISSUE SPECIFICITY Ubiquitously expressed.SIMILARITY Belongs to the small GTPase superfamily. Arf family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12472448] RefSeq:NP_001243058.1 [DatabaseIdentifier:12472447] RefSeq:NP_620150.1 [DatabaseIdentifier:12289958] Pharos - Targets:Q96BM9 [DatabaseIdentifier:12272256] PRO:Q96BM9 [DatabaseIdentifier:12211139] PDB:1ZD9 [DatabaseIdentifier:12211138] PDB:4ILE [DatabaseIdentifier:12211140] PDB:2H18 [DatabaseIdentifier:12129747] OpenTargets:ENSG00000143862 [DatabaseIdentifier:11845107] HPA:ENSG00000143862-ARL8A [DatabaseIdentifier:11808108] GlyGen:Q96BM9 [DatabaseIdentifier:11792112] GeneCards:ARL8A [DatabaseIdentifier:11763613] ENSEMBL:ENST00000272217 [DatabaseIdentifier:11640914] ENSEMBL:ENSP00000272217 [DatabaseIdentifier:11521423] ENSEMBL:ENSG00000143862
databaseName	UniProt
dbId	219112
description	recommendedName: ADP-ribosylation factor-like protein 8A alternativeName: ADP-ribosylation factor-like protein 10B alternativeName: Novel small G protein indispensable for equal chromosome segregation 2
displayName	UniProt:Q96BM9 ARL8A
geneName	ARL8A ARL10B GIE2
identifier	Q96BM9
isSequenceChanged	false
keyword	3D-structure Cell cycle Cell division Cell projection Chromosome partition Cytoplasm Cytoskeleton Endosome GTP-binding Lysosome Membrane Mitosis Nucleotide-binding Protein transport Proteomics identification Reference proteome Synapse Transport
modified	[InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType	Protein
name	ARL8A
otherIdentifier	11736108_at 11736109_at 11736110_a_at 127829 16697985 225347_3p_at 225347_PM_at 225347_at 2451138 2451140 2451141 2451142 2451143 2451144 2451145 2451146 2451147 2451148 2451149 2451150 2451153 2451154 56647_at 56648_g_at 64411_at 78192_at 7923394 A_23_P138271 A_23_P415033 GE905486 GO:0000166 GO:0003924 GO:0005515 GO:0005525 GO:0005737 GO:0005764 GO:0005765 GO:0005768 GO:0005819 GO:0005856 GO:0005886 GO:0007018 GO:0007059 GO:0008089 GO:0008092 GO:0015031 GO:0016020 GO:0016787 GO:0030424 GO:0030496 GO:0031902 GO:0035577 GO:0042995 GO:0043014 GO:0043226 GO:0045202 GO:0048487 GO:0051233 GO:0051301 GO:0070062 GO:0101003 GO:1904115 HMNXSV003016791 Hs.4779.0.S1_3p_at Hs.4779.0.S1_3p_x_at ILMN_1659148 PH_hs_0028199 TC01003699.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6801066] ARL8A [ficolin-1-rich granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801539] ARL8A [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801069] ARL8A [azurophil granule membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12715910] UCSC:Q96BM9 ARL8A [ReferenceDNASequence:12114369] OMIM:616597 ARL8A [ReferenceDNASequence:12099181] NCBI Gene:127829 ARL8A [ReferenceDNASequence:12015088] Monarch:127829 ARL8A [ReferenceDNASequence:11921858] KEGG:hsa:127829 ARL8A [ReferenceDNASequence:11823791] HGNC:25192 ARL8A [ReferenceDNASequence:11432854] dbSNP Gene:127829 ARL8A [ReferenceDNASequence:11420119] CTD Gene:127829 ARL8A [ReferenceDNASequence:11396414] COSMIC - genes:ARL8A ARL8A [ReferenceDNASequence:11385299] BioGPS Gene:127829 ARL8A [ReferenceDNASequence:ensembl:ENSG00000143862] ENSEMBL:ENSG00000143862 ARL8A
referenceTranscript	[ReferenceRNASequence:12653920] RefSeq:NM_001256129.1 ARL8A [ReferenceRNASequence:12653919] RefSeq:NM_138795.4 ARL8A
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ARL8A_HUMAN B3KXD0
sequenceLength	186
species	[Species:48887] Homo sapiens
stId	uniprot:Q96BM9
url	http://purl.uniprot.org/uniprot/Q96BM9

Referrals

(interactor)	[UndirectedInteraction:11185085] UniProt:Q96EN8 <-> UniProt:Q96BM9 (IntAct) [UndirectedInteraction:11142203] UniProt:Q13573 <-> UniProt:Q96BM9 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6801066] ARL8A [ficolin-1-rich granule membrane] [EntityWithAccessionedSequence:R-HSA-6801539] ARL8A [plasma membrane] [EntityWithAccessionedSequence:R-HSA-6801069] ARL8A [azurophil granule membrane]